Navigating a fine balance: point-mutant cheater viruses disrupt the viral replication cycle
Moran Meir,
Arielle Kahn,
Carmel Farage
et al.
Abstract:Cheater viruses, alternatively denoted as defective interfering viruses, cannot replicate on their own yet replicate faster than the wild type (WT) when the two viruses coinfect the same cell. Cheaters must possess dual genetic features: a defect, which leads to their inability to infect cells on their own, and a selective advantage over WT during co-infection. Previously, we have discovered two point-mutant cheaters of the MS2 bacteriophage. Here, we set out to discover the possible repertoire of cheater MS2 … Show more
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