Navigated Three Dimensional Beta Probe for Optimal Cancer Resection

Wendler, Thomas; Traub, Joerg; Ziegler, Sibylle; Navab, Nassir

doi:10.1007/11866565_69

Cited by 21 publications

(11 citation statements)

References 6 publications

(9 reference statements)

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“…To take advantages of nuclear probes and to generate intraoperative functional images, our group introduced the idea of combining currently available probe systems with position and orientation tracking systems [7,8].…”

Section: Functional Imaging With Navigated Nuclear Probesmentioning

confidence: 99%

Navigated nuclear probes for intra-operative functional imaging

Navab¹,

Traub²,

Wendler³

et al. 2008

2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro

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Since the 1920s, functional imaging has continuously contributed with novel methods in medical diagnostics. Its usage in the operation room has been limited in the past, although there is a great potential for localization of target structures and control of the surgery outcome. One example of functional information in the operation room is the use of nuclear probes. These devices are radiation detectors that provide a 1D signal that allows the surgeons to get information about the distribution of a radioactive labeled structure. We extended nuclear probes with a spatial localization system in order to generate functional 3D surface images or functional tomographic images in the operating room. In this paper we summarize our methodology, discuss current limitations and possible remedies, and provide an outlook towards a new generation of image guided surgery based on anatomical and functional intraoperative imaging.

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Section: Functional Imaging With Navigated Nuclear Probesmentioning

confidence: 99%

Navigated nuclear probes for intra-operative functional imaging

Navab¹,

Traub²,

Wendler³

et al. 2008

2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro

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“…The determination of position and orientation of ultrasound and nuclear probes in a common coordinate system can be achieved by an optical tracking system, as in our previous work, where we track a beta-probe optically and generate the radioactivity surface distribution of the resection borders of a tumor [6]. A similar approach is used in this work.…”

Section: System Componentsmentioning

confidence: 99%

Real-Time Fusion of Ultrasound and Gamma Probe for Navigated Localization of Liver Metastases

Wendler¹,

Feuerstein²,

Traub³

et al. 2007

Medical Image Computing and Computer-Assisted Intervention – MICCAI 2007

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Abstract. Liver metastases are an advanced stage of several types of cancer, usually treated with surgery. Intra-operative localization of these lesions is currently facilitated by intra-operative ultrasound (IOUS) and palpation, yielding a high rate of false positives due to benign abnormal regions. In this paper we present the integration of functional nuclear information from a gamma probe with IOUS, to provide a synchronized, real-time visualization that facilitates the detection of active metastases intra-operatively. We evaluate the system in an ex-vivo setup employing a group of physicians and medical technicians and show that the addition of functional imaging improves the accuracy of localizing and identifying malignant and benign lesions significantly. Furthermore we are able to demonstrate that the inclusion of an advanced, augmented visualization provides more reliability and confidence on classifying these lesions in the presented evaluation setup. MotivationLiver metastases are a common consequence of cancer cells spreading from primary tumors. Surgical resection is the indicated therapy if possible, as it results in a cure with high probability [1]. To facilitate extraction, intra-operative localization of the tumorous regions is achieved by a combination of palpation and intra-operative ultrasound (IOUS). This technique is considered the gold standard as it has been in successful clinical practice for years already with a proved high sensitivity [2,3]. However, in the presence of benign abnormal structures, a considerable false-positive detection rate still remains. These abnormalities may be cysts, hemangiomas, scar tissue, or even metastases, which were previously diagnosed by e.g. PET/CT and treated successfully with chemotherapy or other neoadjuvant therapies [3]. This problem, although reduced, is still present when using contrast-enhanced ultrasound [2], which has a promising potential for better image quality, but still remains a mostly anatomical imaging modality.To reduce the detection rate of false-positives, the integration of a functional modality to complement the standard localization technique is a promising approach. A prime candidate for this is nuclear imaging, as there are tracers with

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“…A β -probe is used to detect nuclear labeled malignant cells. Recent work in our group [21] extends the one-dimensional signal of the β -probe to a surface map of the scanned activity. The probe is tracked using a four-camera setup and a retroreflective 4 ball target.…”

Section: Example Application: Navigated β -Probe For Tumor Resectionsmentioning

confidence: 99%

Predicting and estimating the accuracy of n-occular optical tracking systems

Bauer

Schlegel

Pustka

et al. 2006

2006 IEEE/ACM International Symposium on Mixed and Augmented Reality

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Marker-based optical tracking systems are widely used in augmented reality, medical navigation and industrial applications. We propose a model for the prediction of the target registration error (TRE) in these kinds of tracking systems by estimating the fiducial location error (FLE) from two-dimensional errors on the image plane and propagating that error to a given point of interest. We have designed a set of experiments in order to estimate the actual parameters of the model for any given tracking system. We present the results of a study which we used to demonstrate the effect of different sources of error. The method is applied to real applications to show the usefulness for any kind of augmented reality system. We also present a set of tools that can be used to visualize the accuracy at design time.

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Navigated Three Dimensional Beta Probe for Optimal Cancer Resection

Cited by 21 publications

References 6 publications

Navigated nuclear probes for intra-operative functional imaging

Navigated nuclear probes for intra-operative functional imaging

Real-Time Fusion of Ultrasound and Gamma Probe for Navigated Localization of Liver Metastases

Predicting and estimating the accuracy of n-occular optical tracking systems

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