Navel orange peel hydroethanolic extract as a phytogenic feed supplement: impacts on growth, feed intake, nutrient digestibility, and serum metabolites of heat stressed growing rabbits

Orange peels and Chlorella vulgaris supplementation ameliorate gamma radiation‐induced oxidative stress by regulating TGF‐β and NOX2/NOX4 signaling pathways

“…Thrall et al 72 found decrease in PLT with exposure to ionizing radiation due to consumption of coagulation factors and platelets throughout the body's blood vessels. Whereas, supplementation with orange peels and C. vulgaris induced a notable amelioration (the decreased percentages recorded were −51.2%,−15.3%, −4.0%, and −13.7% respectively as compared with the control group), as shown in Table 4; the recorded improvement was in accordance with Badawya et al 56 and Abd El‐Gwaad et al 57 It could be attributed to the antioxidant contents of C. vulgaris and orange peels 13,73 …”

“…Whereas, supplementation with orange peels and C. vulgaris induced a notable amelioration (the decreased percentages recorded were −51.2%,−15.3%, −4.0%, and −13.7% respectively as compared with the control group), as shown in Table 4; the recorded improvement was in accordance with Badawya et al 56 and Abd El-Gwaad et al 57 It could be attributed to the antioxidant contents of C. vulgaris and orange peels. 13,73 3.1.4 | The effects on TGF-β1 and NOX2/NOX4 signaling pathways A high dosage of ionizing radiation (2 Gy twice per week for up to 2 weeks for total fractionated 8 Gy) resulted in a significant (p ≤ 0.05) increase in the expression of the TGF-β1 and NOX2/NOX4 Signaling Pathways (TGF-β1: 5.3 fold, NOX2: 8 fold, and NOX4: 6.4 fold in comparison to normal control). This increase in the expression was in agreement with results obtained by Hanson et al 74 The recorded increase could be attributed to the induction of TGF-β1, NOX2, and NOX4 expression by gamma radiation-induced ROS.…”

Impacts of Heat Stress on Rabbit Immune Function, Endocrine, Blood Biochemical Changes, Antioxidant Capacity and Production Performance, and the Potential Mitigation Strategies of Nutritional Intervention

“…Furthermore, El-Desoky et al ( 111 ) reported that Moringa oleifera leaves ethanolic extract (MLEE) supplementation at a level of 50 mg·kg −1 body weight could be effectively used to enhance heat tolerance, oxidative status and semen quality of rabbit bucks under heat stress. Al-Sagheer et al ( 112 ) suggested that addition of 1,000 mg·kg −1 in diet could improve the hematological and antioxidative indicators, and efficiently mitigate the detrimental effects of chronic temperature stress on performance, hematobiochemical features, and oxidative stability. El-Desoky et al ( 113 ) indicated that nanoencapsulated MLEE has 30 active components, which alleviates (supplemental dose of 10 mg·kg −1 body weight) the negative impacts of heat stress by improving metabolism, redox status, and hormonal balance of rabbit does during summer, thereby increase the reproductive performance (e.g., total litter size, kindling rate, litter size at birth and litter weight at birth).…”

The effects of herbal plant extract on the growth performance, blood parameters, nutrient digestibility and carcase quality of rabbits: A meta-analysis

“… Ragab et al (2022) 0–0.06 Powder Maca ( Lepidium meyenii ) 6–20 V-line FCR, ADG, ADFI, RBC, WBC, Lymphocyte, Haemoglobin Total protein, glucose, triglyceride, albumin, HDL, LDL, carcass weight, kidney, liver, heart, 32. [ 11 ] 0–1.0 Powder Orange (Citrus) 6–14 NZ white BWG, FCR, ADG, Mortality, ADFI, RBC, WBC, Lymphocyte, Glucose, Cholesterol, Triglyceride, HDL, LDL, Carcass, kidney, liver, heart, DPD, CPD 33. [ 36 ] 0.-0.5 Powder Rosemary ( Salvia rosmarinus Thyme ( Thymus vulgaris) Black cumin ( Nigella sativa) Fenugreek seeds (Trigonella foenum-graecum) 28–77 NZ white ADG, ADFI, FCR, BWG, DMD, CPD, Carcass, slaughtered weight ADFI – average daily feed intake; ADG – average daily gain; BWG – body weight gain; DMD – dry matter digestibility; CPD – crude protein digestibility; FCR – feed conversion ratio; HDL - high-density lipoprotein; LDL - low-density lipoprotein; IgG - Immunoglobulin G; IgM - immunoglobulin M; NZ – New Zealand; RBC – red blood cells; SW – slaughtered weight, WBC – white blood cells.…”

“…After several steps of evaluation, the final dataset consisted of 33 in vivo studies comprising 121 experimental units. The peer-reviewed article that met the criteria are (Abdelnour et al, 2018; Abou-Kassem et al, 2021; Abdel-Wareth et al, 2018; 2019; Abd-El-Hady et al, 2014; Al-Sagheer et al (2021); Adewale et al, 2021; Afolabi et al, 2019; Alagbe, 2021; Amaduruonye et al, 2017; Cardinali et al, 2015; Cullere et al, 2016; Dalle Zotte et al, 2013; 2020; Elghalid et al, 2020; Elwan et al, 2020; Elwardany et al (2022); Ismail et al, 2019; Khaled and Qataf (2022); Kovitvadhi et al, 2016; Li et al, 2023; Mohammed et al, 2018; Olatunji et al, 2018; Palazzo et al, 2020; Peiretti et al, 2011; Perna et al, 2019; Popović et al, 2017; Ragab et al (2022); Rotolo et al, 2013; Suliman et al, 2023; Trebušak et al, 2014; Wang et al, 2021; Zanouny and Elwan, 2017) [ [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] ].…”