Naupliolide, a Sesquiterpene Lactone with a Novel Tetracyclic Skeleton from Nauplius graveolens subsp. odorus.

Abstract

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Antioxidant, antibacterial activities and phytochemical screening of Asteriscus pygmaeus aerial parts ethanolic extract

“…The concentrated extract was chromatographed on a polyamide column; elution being performed with water followed by water ethanol mixtures to give six fractions. These fractions were further chromatographed on paper and subcolumn chromatography to isolate and purified their flavonoid constituents using various solvents to afford nine natural flavonoid compounds among of them one new compound: -6-Hydroxy kaempferol-6-methyl ether (eupafolin) -4' glucopyranoside (1) together with eight known metabolites;patuletin 7glucoside (2), chrysoeriol 7-O-glucoside(3), 6-Hydroxykaempferol (4),6-Hydroxykaempferol 6-methyl ether (eupafolin) (5), 6,4` dimethoxyluteolin (6), patuletin(7),chrysoeriol(8) and luteolin (9). Their chemical structures have been established by conventional methods of chemical and physical analysis and confirmed by NMR spectroscopy.…”

“…Asteriscus pygmaeus plant under investigation, belongs to Asteraceae family which consists of eight species and five sub-species extend from North Africa to the desert regions of Asia [5]. According to literature, Asteriscus genera are characterized by a high content of flavonoids, phenolics [6], [7], sesquiterpenes [5], bisabolone [8] and hydroperoxides [9]. Antimicrobial and antioxidant activities of some Asteraceae extracts constituents have documented [10][11][12] against many fungal and bacterial pathogens [13,14].…”