Nauphoeta cinerea as an emerging model in neurotoxicology

Adedara, Isaac A.; Mohammed, K A; Canzian, Julia; Aschner, Michael; Farombi, Ebenezer O.; Rocha, João B. T.

doi:10.1016/bs.ant.2023.01.004

Cited by 2 publications

(2 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The N . cinerea represents an ideal biosensor to characterize insect behavioral responses to xenobiotics via high‐throughput approaches 30 . Thus, this study aims to fill this research gap on a nontarget insect species by elucidating the impact of metoprolol in developing N .…”

Section: Introductionmentioning

confidence: 99%

“…The N. cinerea represents an ideal biosensor to characterize insect behavioral responses to xenobiotics via high-throughput approaches. 30 Thus, this study aims to fill this research gap on a nontarget insect species by elucidating the impact of metoprolol in developing N. cinerea nymphs. We hypothesized that exposure of N. cinerea nymphs to metoprolol may lead to modifications in biochemical and neurobehavioral responses in these nontarget organisms.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Metoprolol elicits neurobehavioral insufficiency and oxidative damage in nontarget Nauphoeta cinerea nymphs

Oyedele

Adedara

Ikeji

et al. 2023

Environmental Toxicology

View full text Add to dashboard Cite

Metoprolol, a drug for hypertension and cardiovascular diseases, has become a contaminant of emerging concern because of its frequent detection in various environmental matrices globally. The dwindling in the biodiversity of useful insects owing to increasing presence of environmental chemicals is currently a great interest to the scientific community. In the current research, the toxicological impact of ecologically relevant concentrations of metoprolol at 0, 0.05, 0.1, 0.25, and 0.5 μg/L on Nauphoeta cinerea nymphs following exposure for 42 consecutive days was evaluated. The insects' behavior was analyzed with automated video‐tracking software (ANY‐maze, Stoelting Co, USA) while biochemical assays were done using the midgut, head and fat body. Metoprolol‐exposed nymphs exhibited significant diminutions in the path efficiency, mobility time, distance traveled, body rotation, maximum speed and turn angle cum more episodes, and time of freezing. In addition, the heat maps and track plots confirmed the metoprolol‐mediated wane in the exploratory and locomotor fitness of the insects. Compared with control, metoprolol exposure decreased acetylcholinesterase activity in insects head. Antioxidant enzymes activities and glutathione level were markedly decreased whereas indices of inflammation and oxidative injury to proteins and lipids were significantly increased in head, midgut and fat body of metoprolol‐exposed insects. Taken together, metoprolol exposure induces neurobehavioral insufficiency and oxido‐inflammatory injury in N. cinerea nymphs. These findings suggest the potential health effects of environmental contamination with metoprolol on ecologically and economically important nontarget insects.

show abstract

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Metoprolol elicits neurobehavioral insufficiency and oxidative damage in nontarget Nauphoeta cinerea nymphs

Oyedele

Adedara

Ikeji

et al. 2023

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

Neural acetylcholinesterase and monoamine oxidase deregulation during streptozotocin-induced behavioral, metabolic and redox modification in Nauphoeta cinerea

Ogunsuyi,

Olagoke,

Famutimi

et al. 2024

BMC Neurosci

View full text Add to dashboard Cite

Genetic and environmental factors have been linked with neurodegeneration, especially in the elderly. Yet, efforts to impede neurodegenerative processes have at best addressed symptoms instead of underlying pathologies. The gap in the understanding of neuro-behavioral plasticity is consistent from insects to mammals, and cockroaches have been proven to be effective models for studying the toxicity mechanisms of various chemicals. We therefore used head injection of 74 and 740 nmol STZ in Nauphoeta cinerea to elucidate the mechanisms of chemical-induced neurotoxicity, as STZ is known to cross the blood-brain barrier. Neurolocomotor assessment was carried out in a new environment, while head homogenate was used to estimate metabolic, neurotransmitter and redox activities, followed by RT-qPCR validation of relevant cellular signaling. STZ treatment reduced the distance and maximum speed travelled by cockroaches, and increased glucose levels while reducing triglyceride levels in neural tissues. The activity of neurotransmitter regulators – AChE and MAO was exacerbated, with concurrent upregulation of glucose sensing and signaling, and increased mRNA levels of redox regulators and inflammation-related genes. Consequently, STZ neurotoxicity is conserved in insects, with possible implications for using N. cinerea to target the multi-faceted mechanisms of neurodegeneration and test potential anti-neurodegenerative agents.

show abstract

Nauphoeta cinerea as an emerging model in neurotoxicology

Cited by 2 publications

References 68 publications

Metoprolol elicits neurobehavioral insufficiency and oxidative damage in nontarget Nauphoeta cinerea nymphs

Metoprolol elicits neurobehavioral insufficiency and oxidative damage in nontarget Nauphoeta cinerea nymphs

Neural acetylcholinesterase and monoamine oxidase deregulation during streptozotocin-induced behavioral, metabolic and redox modification in Nauphoeta cinerea

Contact Info

Product

Resources

About