Nature, time-course, and extent of cerebral edema in perinatal hypoxic-ischemic brain damage

Vannucci, Robert C.; Christensen, Melanie A.; Yager, Jerome Y.

doi:10.1016/0887-8994(93)90006-x

Cited by 74 publications

(37 citation statements)

References 26 publications

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“…Similar to our previous findings and those of others using the Rice-Vannucci model of neonatal HI injury, in the present study we observed unilateral brain lesions (10,17,23), which were accompanied by behavioral deficits. There were large lesions affecting the ipsilateral (right) hemisphere in HI rats, including damage to cortical and striatal regions (Fig.…”

Section: Resultssupporting

confidence: 81%

Long-Term Functional and Protective Actions of Preconditioning With Hypoxia, Cobalt Chloride, and Desferrioxamine Against Hypoxic-Ischemic Injury in Neonatal Rats

et al. 2008

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ABSTRACT:Preconditioning with hypoxia and hypoxia-mimetic compounds cobalt chloride (CoCl 2 ) and desferrioxamine (DFX) protects against hypoxic-ischemic (HI) injury in neonatal rat brain. We examined long-term functional and protective actions of preconditioning induced by hypoxia, CoCl 2 and DFX in a neonatal rat model of HI. Postnatal day six rat pups were exposed to preconditioning with hypoxia (8% oxygen) or injections of CoCl 2 , DFX or saline vehicle and 24 h later rats underwent HI or sham surgery. Behavioral tests were performed and at the conclusion of experiments, brains removed for morphologic analyses. HI resulted in a large unilateral lesion in the ipsilateral hemisphere compared with sham control rats. All preconditioning treatments significantly reduced the total lesion volume. Behavioral deficits were observed in HI rats compared with sham controls. The reduction in forelimb grasping strength in HI rats was attenuated by preconditioning with hypoxia, CoCl 2 and DFX. HI increased the number of foot faults in a grid-walking test and resulted in forelimb asymmetry in the cylinder test. Only preconditioning with hypoxia reversed all three functional deficits after HI. These findings indicate that preconditioning, especially when induced by hypoxia, has the potential to minimize the morphologic and functional effects of neonatal HI injury. (Pediatr Res 63: 620-624, 2008)

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Section: Resultssupporting

confidence: 81%

Long-Term Functional and Protective Actions of Preconditioning With Hypoxia, Cobalt Chloride, and Desferrioxamine Against Hypoxic-Ischemic Injury in Neonatal Rats

et al. 2008

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“…O status dymielinisatus caracteriza-se por perda da bainha de mielina da cápsula interna, diminuição dos neurônios dos núcleos basais e gliose. É uma situação bem mais rara do que a anterior 13,17 .…”

Section: Cerebral Palsy New Therapeutic Possibilitiesunclassified

Paralisia cerebral, novas perspectivas terapêuticas

Rotta¹

2002

J. Pediatr. (Rio J.)

119

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ResumoObjetivo: a revisão da paralisia cerebral tem como objetivo oferecer ao pediatra informações atualizadas sobre o diagnóstico e tratamento.Fontes dos dados: foram utilizados dados de revisão bibliográ-fica não sistematizada e da experiência no atendimento dos pacientes da Unidade de Neurologia do Serviço de Pediatria do HCPA-UFRGS. Síntese dos dados:o diagnóstico e tratamento da paralisia cerebral é multidisciplinar. Ao lado do sintoma principal motor, estão os sintomas associados que requerem igual atenção. Os exames de neuroimagem são importantes para melhor localizar a lesão, e mostrar sua extensão e características. O EEG auxilia no diagnóstico das epilepsias associadas. O tratamento principal é fisioterápico, auxiliado pelo tratamento da espasticidade, com antiespásticos orais, ou com toxina botulínica injetável. O tratamento de epilepsia secundária varia de acordo com o tipo de crise.Conclusões: o pediatra é o primeiro médico a entrar em contato com a criança com paralisia cerebral, e deve estar apto para reconhecer precocemente os desvios do desenvolvimento, orientar o manejo e, dentro das possibilidades e necessidades, encaminhar ao especialista. J Pediatr (Rio J) 2002; 78 (Supl.1):S48-S54: lesão cerebral, neurologia pediátrica, espasticidade. AbstractObjective: to provide pediatrician with updated information about diagnoses and treatment of cerebral palsy. This articles aims at supplying pediatricians with tools that will help them diagnose and treat cerebral palsy. Conclusions: pediatricians are the first physician that see the patient with cerebral palsy. Thus, they should be able to diagnose an treat it.J Pediatr (Rio J) 2002; 78 (Supl.1): S48-S54: cerebral palsy, neurology, pediatrics, spasticity.

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“…We did not detect any histopathologic changes in this tissue. This may be explained by the fact that a dual insult of both hypoxia and ischemia is necessary to cause histopathologic injury of brain (14,18,35).…”

Section: Discussionmentioning

confidence: 99%

“…Immediately after birth, the newborn rats were placed in 500-mL airtight jars, and hypoxia was induced by breathing of a mixture of 92% nitrogen and 8% oxygen for 3 h. The jars were partially submerged in a water bath thermostatically regulated at 3rc. After the hypoxic period, the rats were transferred to another jar at 3rC where they were allowed to inhale normal atmospheric air for 30 min (14,15).…”

Section: Methodsmentioning

confidence: 99%

The Effect of High Dose Antenatal Vitamin E on Hypoxia-Induced Changes in Newborn Rats

Inan

Kılıç

Kılınç³

et al. 1995

Pediatr Res

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Vol. 38 , No. 5, 1995 Printed ill U.S.A.Th e protecti ve effects of high dose antenatal vitam in E on hypoxemi a in newb orn rats were inves tiga ted. The subjects we re l-d-cld Wistar rats we ig hing 5-6 g whi ch were born to mothers weighing 245-250 g. Thr ee groups of rat pups , each consisting of eight newb orn rats, were used: non treated control group, hypoxic gro up, and vitamin E gro up. Th e moth ers of pups in the last gro up were given vitamin E (2000 mg/kg/d) antenatally on 3 consec utive days. Hypoxia was induc ed by breathing of a mixture of 8% oxygen and 92% nitrogen for 3 h. Then pups we re allowed to inhale norm al atmospheric air for 30 min. All rats were killed on the first day of life after the procedure of hypoxia and reoxygenatio n. The brains, lungs, livers, intestin es, and kidneys were studied biochemi cally and histopatholog ically. The hypoxia-indu ced biochemi cal changes were determined by measuring lipid peroxidation and myelopero xidase activity. Vitam in E effectively inhibi ted hypox ia-indu ced lipid peroxid ation in liver and intestines, and dec reased the levels of thiobarbituric Hypoxia and ischemia are major problems in the neonate despit e advanced antenatal and neonat al care. No specific treatment has been shown to improve the high morbidity and mortality associated with this problem .Among many factors that adversely effect the function of placenta in the gas exchange between the fetus and the mother are maternal hypoperfusion induc ed by anesthesia, uterine hypertonicity, abrupti o placenta, and obstruction of the umbilical cord. An y episode of fetal hypoperfusion can cause mild or severe fetal hypoxemia (1). After the reintroduction of oxygen, large amounts of oxygen-free radicals are produced. These radicals can initiate lipid peroxidati on and attack other biologic targets (2-4).Low levels of oxygen radicals produced under physiologic conditions are effectively removed or scave nged by enzymatic and nonen zymati c antioxidant syste ms of the body (5, 6). However, under several pathologic conditions these antioxidant mechanisms may be overw helmed by radicals produ ced in excessive amounts.

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Nature, time-course, and extent of cerebral edema in perinatal hypoxic-ischemic brain damage

Cited by 74 publications

References 26 publications

Long-Term Functional and Protective Actions of Preconditioning With Hypoxia, Cobalt Chloride, and Desferrioxamine Against Hypoxic-Ischemic Injury in Neonatal Rats

Long-Term Functional and Protective Actions of Preconditioning With Hypoxia, Cobalt Chloride, and Desferrioxamine Against Hypoxic-Ischemic Injury in Neonatal Rats

Paralisia cerebral, novas perspectivas terapêuticas

The Effect of High Dose Antenatal Vitamin E on Hypoxia-Induced Changes in Newborn Rats

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