Nature stays natural: two novel chemo-enzymatic one-pot cascades for the synthesis of fragrance and flavor aldehydes

Abstract

Novel synthetic strategies for the production of high-value chemicals based on the 12 principles of green chemistry are highly desired. Herein, we present a proof of concept for two novel...

One-pot chemo- and photo-enzymatic linear cascade processes

“…With interest in synthesizing fragrant aldehydes the same authors proposed two different catalytic routes starting from substituted phenyl propenes. 152 Route A (Scheme 31(a)) involves catalytic isomerization of the allylic alkene group followed by the alkene group cleavage performed using an aromatic dioxygenase enzyme (ADO). Route A was performed in a sequential mode by using PdCl 2 as the isomerization catalyst, followed by the addition of ADO (whole cells) after dilution of the reaction media with phosphate buffer and EtOH.…”