Nature products of traditional Chinese medicine provide new ideas in γδT cell for tumor immunotherapy

Duya, Paulina Atieno; Chen, Yinxiao; Bai, Liding; Li, Zhaodong; Chai, Rundong; Bian, Yuhong; Zhao, Shuwu

doi:10.1097/hm9.0000000000000032

Cited by 17 publications

(12 citation statements)

References 38 publications

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“…Therefore, it stimulates Treg cell-guided immune networks and can inhibit inflammatory diseases, such as early malignant transformation. In recent years, it has been shown that tumor control can be achieved through γδ T cell exosomes and the use of chimeric antigen receptor-γδ T cell immunotherapy ( Duya et al, 2022 ).…”

Section: Probiotics Develop Through An Immunomodulatory Anti-tumor Oc...mentioning

confidence: 99%

The role of the gut microbiota and probiotics associated with microbial metabolisms in cancer prevention and therapy

Wang

et al. 2022

Front. Pharmacol.

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Cancer is the second leading cause of elevated mortality worldwide. Thus, the development of drugs and treatments is needed to enhance the survival rate of the cancer-affected population. Recently, gut microbiota research in the healthy development of the human body has garnered widespread attention. Many reports indicate that changes in the gut microbiota are strongly associated with chronic inflammation-related diseases, including colitis, liver disease, and cancer within the intestine and the extraintestinal tract. Different gut bacteria are vital in the occurrence and development of tumors within the gut and extraintestinal tract. The human gut microbiome has significant implications for human physiology, including metabolism, nutrient absorption, and immune function. Moreover, diet and lifestyle habits are involved in the evolution of the human microbiome throughout the lifetime of the host and are involved in drug metabolism. Probiotics are a functional food with a protective role in cancer development in animal models. Probiotics alter the gut microbiota in the host; thus, beneficial bacterial activity is stimulated, and detrimental activity is inhibited. Clinical applications have revealed that some probiotic strains could reduce the occurrence of postoperative inflammation among cancer patients. An association network was constructed by analyzing the previous literature to explore the role of probiotics from the anti-tumor perspective. Therefore, it provides direction and insights for research on tumor treatment.

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Section: Probiotics Develop Through An Immunomodulatory Anti-tumor Oc...mentioning

confidence: 99%

The role of the gut microbiota and probiotics associated with microbial metabolisms in cancer prevention and therapy

Wang

et al. 2022

Front. Pharmacol.

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“…At present, most studies focus on regulating MDSCs as a whole; however, the mechanisms regulated by different MDSCs subtypes may differ. Only a few studies have explored MDSCs with tumor infiltration, probably own to the difficulty and exorbitant price of isolating MDSCs, and their complex attachment to tumor cells as well as their small proportion, thus effects and inhibitory mechanisms of MDSCs need to be elaborated in detail [ 26 , 143 , 144 ].…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

The role of myeloid-derived suppressor cells in liver cancer

et al. 2023

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MDSCs are immature myeloid immune cells, which accumulate in models of liver cancer to reduce effector immune cell activity, contribute to immune escape and treatment resistance. The accumulation of MDSCs suppresses the role of CTL and the killing effects of NK cells, induces the accumulation of Treg cells, and blocks the antigen presentation of DCs, thus promoting the progression of liver cancer. Recently, immunotherapy has emerged a valuable approach following chemoradiotherapy in the therapy of advanced liver cancer. A considerable increasing of researches had proved that targeting MDSCs has become one of the therapeutic targets to enhance tumor immunity. In preclinical study models, targeting MDSCs have shown encouraging results in both alone and in combination administration. In this paper, we elaborated immune microenvironment of the liver, function and regulatory mechanisms of MDSCs, and therapeutic approaches to target MDSCs. We also expect these strategies to supply new views for future immunotherapy for the treatment of liver cancer.

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“…TCMs treatment has the advantages of fewer side effects and low toxicity. It can play a more comprehensive role in the treatment of diseases through its unique multi-target ( Xiang, et al, 2021 ; Duya, et al, 2022 ; Li, et al, 2023 ). It has a special function in treating tough and complex disorders in particular, and it is indispensable in chemical medicine ( Luo, et al, 2020 ; Zhang, et al, 2020 ; Liao, et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of multiple components in rat plasma by UHPLC-sMRM for pharmacokinetic studies after oral administration of Qingjin Yiqi Granules

Yang

Chen

et al. 2023

Front. Pharmacol.

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As a Traditional Chinese Medicine prescription, Qingjin Yiqi Granules (QJYQ) provides an effective treatment for patients recovering from COVID-19. However, the pharmacokinetics characteristics of the main components of QJYQ in vivo are still unknown. An efficacious ultra-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was developed and validated for the simultaneous determination of 33 components in rat plasma after oral administration of QJYQ. The plasma samples were precipitated with 400 µL methanol/acetonitrile (1/1, v/v) and analyzed in scheduled multiple reaction monitoring mode. The linear relationship of the 33 components was good (r > 0.9928). The lower limit of quantification for 33 components ranged from 0.4–60.5 ng/mL. The average recoveries and matrix effects of the analytes ranged from 72.9% to 115.0% with RSD of 1.4%–15.0%. All inter-day and intra-day RSDs were within 15.0%. After oral administration (3.15 g/kg), the validated approach was effectively applied to the pharmacokinetics of main components of QJYQ. Finally, fifteen main constituents of QJYQ with large plasma exposure were obtained, including baicalin, wogonoside, wogonin, apigenin-7-O-glucuronide, verbenalin, isoferulic acid, hesperidin, liquiritin, harpagide, protocatechuic acid, p-Coumaric acid, ferulic acid, sinapic acid, liquiritin apioside and glycyrrhizic acid. The present research lays a foundation for clarifying the therapeutic material basis of QJYQ and provides a reference for further scientific research and clinical application of QJYQ.

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Nature products of traditional Chinese medicine provide new ideas in γδT cell for tumor immunotherapy

Cited by 17 publications

References 38 publications

The role of the gut microbiota and probiotics associated with microbial metabolisms in cancer prevention and therapy

The role of the gut microbiota and probiotics associated with microbial metabolisms in cancer prevention and therapy

The role of myeloid-derived suppressor cells in liver cancer

Simultaneous determination of multiple components in rat plasma by UHPLC-sMRM for pharmacokinetic studies after oral administration of Qingjin Yiqi Granules

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