Nature of the transient species formed in the pulse radiolysis of some thiourea derivatives

Dey, G.R.; Naik, D.B.; Kishore, Kamal; Moorthy, P.N.

doi:10.1039/p29940001625

Cited by 30 publications

(33 citation statements)

References 5 publications

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“…As can be seen, the transients formed from the hydrated electron and the hydrogen atom only absorb slightly in the wavelength range studied. This is consistent with the recent publication by Dey et al (21). The hydroxyl radical induced spectrum has a maximum extinction coefficient of 7100 dm3 mol-' cm-' near 425 nm.…”

Section: Radiolysis Studies Of 1-hexyn-3-01supporting

confidence: 82%

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Radiolysis studies on the corrosion inhibitors 1 -hexyn-3-ol, cinnamonitrile, and 1,3-diethyl-2-thiourea

Elliot¹,

Chenier²,

Ouellette³

1995

Can. J. Chem.

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Abstract:In this publication we report: (i) the rate constants for reaction of the hydrated electron with l-hexyn-3-01 ((8.6 ? 0.3) x lo8 dm3 mol-' s-' at lS°C), cinnamonitrile ((2.3 ? 0.2) x dm3 mol-I s-' at 2OoC), and 1,3-diethyl-2-thiourea ((3.5 ? 0.3) x lo8 dm3 mol-I s-I at 22'C). For cinnamonitrile and diethylthiourea, the temperature dependence up to 200°C and 150°C, respectively, is also reported; (ii) the rate constants for the reaction of the hydroxyl radical with 1-hexyn-3-ol((5.5 ? 0.5) x lo9 dm3 mol-I s-I at 20°C), cinnamonitrile ((9.2 ? 0.3) x lo9 dm3 mol-I s-I at 21°C), and diethylthiourea ((8.0 ? 0.8) x lo8 dm3 mol-I s-I at 22OC). For cinnamonitrile, the temperature dependence up to 200°C is also reported; (iii) the rate constant for the hydrogen atom reacting with 1-hexyn-3-01 ((4.3 ? 0.4) x lo9 dm3 mol-I s-' at 20°C).

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Section: Radiolysis Studies Of 1-hexyn-3-01supporting

confidence: 82%

“…The value of 5 x lo8 dm3 mol-' s-' reported in ref. 21 for klo is slightly higher than that reported here.…”

Section: Radiolysis Studies Of Diethylthioureacontrasting

confidence: 53%

Radiolysis studies on the corrosion inhibitors 1 -hexyn-3-ol, cinnamonitrile, and 1,3-diethyl-2-thiourea

Elliot¹,

Chenier²,

Ouellette³

1995

Can. J. Chem.

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“…We hypothesize that these decompositionp roducts arise from radiolysis of the conjugate. [18] Notably,t his radiolysis effect is not observed for DO2Apic-DUPA ( Figure S33), suggesting that it may occur due to the presence of the aromatict hiourea linkageinmacropa-DUPA. The radiolysis of 132/135 La(macropa)-DUPAc ould be attenuated by the addition of sodium ascorbate, enabling the intact radiolabeled conjugate to be obtained following solid-phase extraction and formulation( Figure S34).…”

Section: /135mentioning

confidence: 97%

Establishing Radiolanthanum Chemistry for Targeted Nuclear Medicine Applications

Aluicio‐Sarduy

Thiele

Martin

et al. 2020

Chemistry A European J

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We report the first targeted nuclear medicine application of the lanthanum radionuclides 132/135La. These isotopes represent a matched pair for diagnosis via the positron emissions of 132La and therapy mediated by the Auger electron emissions of 135La. We identify two effective chelators, known as DO3Apic and macropa, for these radionuclides. The 18‐membered macrocycle, macropa, bound 132/135La with better molar activity than DO3Apic under similar conditions. These chelators were conjugated to the prostate‐specific membrane antigen (PSMA)‐targeting agent DUPA to assess the use of radiolanthanum for in vivo imaging. The 132/135La‐labeled targeted constructs showed high uptake in tumor xenografts expressing PSMA. This study validates the use of these radioactive lanthanum isotopes for imaging applications and motivates future work to assess the therapeutic effects of the Auger electron emissions of 135La.

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“…For example, sulfur-centered radicals are able to form three-electron-bonded intermediates such as RSSR •− , R 2 SSR •+ 2 , or R 2 SOH • (87). The radiation-induced chemistry of thiourea in aqueous solution has been studied (88)(89)(90)(91)(92)(93)(94)(95)(96)(97), emphasizing its potential application as a radio-protectant. During the process, formamidine disulfide is found to be the major product.…”

Section: Oxidation Of Thiourea To Formamidinium Disulfidementioning

confidence: 99%

Oxidation of thiourea and substituted thioureas: a review

Sahu

Sahoo

Patel

et al. 2011

Journal of Sulfur Chemistry

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Nature of the transient species formed in the pulse radiolysis of some thiourea derivatives

Cited by 30 publications

References 5 publications

Radiolysis studies on the corrosion inhibitors 1 -hexyn-3-ol, cinnamonitrile, and 1,3-diethyl-2-thiourea

Radiolysis studies on the corrosion inhibitors 1 -hexyn-3-ol, cinnamonitrile, and 1,3-diethyl-2-thiourea

Establishing Radiolanthanum Chemistry for Targeted Nuclear Medicine Applications

Oxidation of thiourea and substituted thioureas: a review

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