Nature of the anti-Xa activity induced by a heparin analogue (SSHA) in vivo

Schmitz-Huebner, U.; Lobreyer, E.-M.; Loo, J. van de

doi:10.1016/0049-3848(82)90014-7

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…3). The distribution of the three treatments tested (LMWH 1, LMWH 2, UFH) within the tertiles was as follows: tertile 1 (7,4,7), tertile 2 (5,7,5) and tertile 3 (7,7,4). The tertiles differed significantly in the p.o.…”

Section: Coagulation Parameters In Relation To Clinical Findingsmentioning

confidence: 99%

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Influence of Low Molecular Weight Heparin on the Hemostatic System After Abdominal Surgery

et al. 1985

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SummaryThe hemostatic effect of two low molecular weight heparin fractions and of one unfractionated heparin preparation administered subcutaneously b. i. d. was examined in 6 healthy subjects and in 53 patients after major abdominal surgery. Among other tests platelet count, prothrombin time, fibrinogen, β-thrombo- globulin, antithrombin, antiplasmin, FPA and F-CB 3 related antigen, as well as various heparin activities, were repeatedly determined pre- and postoperatively. Under all tested conditions the low molecular weight fractions induced higher heparin levels, both in terms of anti-Xa and of anti-thrombin activity. No further significant differences of the laboratory results between the treatment groups were documented. Total blood loss measured at the first postoperative day was higher in patients with malignancy and negatively correlated with antithrombin and antiplasmin levels, while no relation was observed with the heparin activities and the other tested parameters. Whereas evidence for a hemorrhagic property of the tested low molecular weight heparin fractions was found, a particular mechanism underlying this effect could not be identified.

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Section: Coagulation Parameters In Relation To Clinical Findingsmentioning

confidence: 99%

“…The most striking effect of LMWH fractions consists in their relatively high anti-Xa activity contrast ing with a reduced potency to inhibit thrombin both in vitro and ex vivo (1,2,3). This anti-Xa activity was shown to be hardly neutralizable by antagonists (4,5) and to have a prolonged half life in the circulation (6).…”

Section: Introductionmentioning

confidence: 99%

Influence of Low Molecular Weight Heparin on the Hemostatic System After Abdominal Surgery

et al. 1985

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A randomized study of a semisynthetic heparin analogue and heparin in prophylaxis of deep vein thrombosis

Törngren¹,

Kettunen²,

Lahtinen³

et al. 1984

British Journal of Surgery

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The prophylactic effect of a semisynthetic heparin analogue (SSHA) on deep vein thrombosis was investigated in a prospective double-blind multicentre trial. 440 major general surgical and gynaecological patients were randomized to one of three treatment groups: 50 mg SSHA, 37.5 mg SSHA and 5000 units sodium heparin subcutaneously 12-hourly. Deep venous thrombosis (DVT) was diagnosed with the fibrinogen uptake test and verified with phlebography. Bleeding complications and other side-effects were carefully monitored. There were no significant differences between the three treatment groups of patients in age, sex, type of operation or risk factors. A DVT was diagnosed in 16 patients (12 per cent) in the SSHA 50 mg group, in 21 patients (15 per cent) in the SSHA 37.5 mg group and 21 patients (14 per cent) in the heparin-treated group. No significant differences were found in the number of patients who bled unexpectedly in the postoperative period, required transfusion or developed wound haematomas. Blood loss at operation was similar in all three groups. Three pulmonary emboli were diagnosed by pulmonary scintigraphy, one in each group.

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Anticoagulant and antithrombotic properties of synthetic sulfated bis-lactobionic acid amides

Raake¹,

Klauser²,

Elling³

et al. 1989

Thrombosis Research

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Nature of the anti-Xa activity induced by a heparin analogue (SSHA) in vivo

Cited by 4 publications

References 14 publications

Influence of Low Molecular Weight Heparin on the Hemostatic System After Abdominal Surgery

Influence of Low Molecular Weight Heparin on the Hemostatic System After Abdominal Surgery

A randomized study of a semisynthetic heparin analogue and heparin in prophylaxis of deep vein thrombosis

Anticoagulant and antithrombotic properties of synthetic sulfated bis-lactobionic acid amides

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