Nature of the Activity of Sulfonamides for the Tubercle Bacillus

Fitzgerald, Robert J.; Feinstone, W. Harry; Clark, Gregory W.

doi:10.3181/00379727-52-14010

Cited by 6 publications

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“…Much of the responsibility for this extreme variability in the ratio probably lies in the variable amounts of sulfonamide-antagonists already present in practically all culture media. The other sulfonamides under the same experimental conditions require relatively more PABA to counteract their action (70,75,84,115,205,246,281,284,287). Analysis of the quantitative data shows that the potency of each sulfonamide is directly proportional to its ability to counteract the anti-bacteriostatic action of PABA, in other words, the amount of PABA required to counteract bacteriostasis is approximately the same for the minimal bacteriostatic concentration of each sulfonamide (75,128,281,284).…”

Section: Sulfonamide-antagomsts11mentioning

confidence: 95%

“…In the presence of PABA the growth-stimulating concentration of SA is increased (136), and, over a wide range of concentrations, the ratio of sulfonamide to the amount of PABA required for antagonism is more or less constant (84,173,205,227,269,281,284,287); these two observations are to be expected from the mass law relationship and, therefore, they offer further support for such a relationship. It has been found that one mole of PABA will counteract approximately 1,000 to 26,000 or more moles of SA (43,70,75,163,226,281,284,287). There have been reported instances in which this ratio is nearer unity (133,169,246,286).…”

Section: Sulfonamide-antagomsts11mentioning

confidence: 99%

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The Mode of Action of the Sulfonamides

Henry

1944

JAMA

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Section: Sulfonamide-antagomsts11mentioning

confidence: 95%

Section: Sulfonamide-antagomsts11mentioning

confidence: 99%

The Mode of Action of the Sulfonamides

Henry

1944

JAMA

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Section: Sulfonamide-antagomsts11mentioning

confidence: 95%

The Mode of Action of Sulfonamides *

Henry¹

1943

Bacteriological Reviews

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Assumptions that the action of sulfonamides is due to their transformation into * The present review is a critical integration of the material believed to be essential to an understanding of the mode of action of the sulfonamides. In order to bring the treatment of the subject within the scope of a review of this character many supporting references and topics have necessarily been excluded. A much more inclusive annotated bibliographic review will be published in the new series of the Josiah Macy, Jr. Foundation.

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“…Evidence has been presented that para-aminobenzoic acid also inhibits the "bacteriostatic" action of sulfonamides (Fitzgerald and Feinstone, 1943) and promin (Steenken and Heise, 1943) on tubercle bacilli, and of sulfonamides on the Plasmodium of bird malaria and on the virus of lymphogranuloma venereum (Maier and Riley, 1942). Green and Bielschowsky (1942) have emphasized that the antisulfonamide activity of bacterial and yeast extracts is exerted directly by para-aminobenzoic acid and similar sulfonamide inhibitors, and indirectly by substances which stimulate bacterial growth, even in an optimal nutrient medium.…”

Section: Proteolytic Enzymes IImentioning

confidence: 99%

Proteolytic Enzymes

Grob

1946

Journal of General Physiology

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Miiller (1888) first described the presence in human purulent sputum of protease active at neutral pH. Achalme (1899) was the first to find this enzyme in human pus. Jobling and Strouse (1912) showed that extracts of human pus also contain peptidase active at neutral pH. Opie (1905Opie ( , 1922 showed that polymorphonuclear leucocytes are the chief source of leucoprotease (named by him) and was the first to emphasize the physiological significance of this protease and of its inhibition by serum. He demonstrated that leucoprotease plays a major rSle in the resolution of in~ammatory exudates, and that serum (in sufficient concentration) can retard this resolution by virtue of its inhibitory power. More recent workers (Hoimes eta/., 1935) have applied these principles to the study of suppurative arthritis and have shown that the presence of antiproteolytic substances in synovlal exudates is of great importance in the prevention of damage to joints by protease liberated from the polymorphonuclear leucocytes of these exudates. However, the general problem of the relation of leucoprotease and serum antiprotease to the resolution and absorption of ioflammatory exudates and absorbable foreign bodies has not been intensively studied since the work of Opie early in the century. It is hoped that the experiments described in the preceding paper on the control of leucoprotease and serum antiprotease will facilitate such a study by enabling better control of the activity of these important substances than has hitherto been possible.The experiments of Menkin (1938) and others indicate that the increased capillary permeability and leucocyte infiltration characteristic of inflammation are due to a polypeptide formed by proteolysis at the site of inflammation.

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Nature of the Activity of Sulfonamides for the Tubercle Bacillus

Cited by 6 publications

References 0 publications

The Mode of Action of the Sulfonamides

The Mode of Action of the Sulfonamides

The Mode of Action of Sulfonamides *

Proteolytic Enzymes

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