Nature of reconstitution with histoincompatible maternal marrow in a case of severe combined immunodeficiency with graft-versus-host disease following maternofetal transfusion

Niethammer, D.; Goldmann, S. F.; Hd, Flad; Bienzle, Ulrich; U, Dieterle; Haas, R.; B, Heymer; Meigel, Wilhelm; Belohradsky, Bernd H.; Kleihauer, E.

doi:10.1016/0090-1229(81)90132-x

Cited by 7 publications

(6 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The passage of cells from mother to fetus is not as well documented, but maternal lymphocytes and erythrocytes have been firmly identified in some human newborns. Engraftment of maternal lymphocytes has been observed in 25% of infants suffering from combined severe immune deficiency [16], and it may lead to a graft-vs.-host disease in some ofthese infants [17][18][19]. The path by which T lymphocytes attain the vascular compartment of the fetus is unknown but one can speculate that these mobile and infiltrating cells could follow other placental routes than breaks in the vasculo syncytial membrane.…”

Section: Discussionmentioning

confidence: 99%

Maternal‐Fetal Hemorrhage: A Reappraisal

Brossard¹,

Pons

Jrad

et al. 1996

Vox Sanguinis

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Maternal‐Fetal Hemorrhage: A Reappraisal

Brossard¹,

Pons

Jrad

et al. 1996

Vox Sanguinis

View full text Add to dashboard Cite

show abstract

“…Several infants with SCID and persistence of transplacentally acquired maternal T cells have been reported in the past several years (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). The diagnosis of SCID in the infant described in this report was delayed because he was not lymphopenic due to the presence of maternal T cells.…”

Section: Discussionmentioning

confidence: 99%

“…In all cases, these maternal lymphocytes have had either no response or very low responses to mitogens, antigens and allogeneic cells in in v i m assays. Graft versus host disease (GVHD) has varied from clinically inapparent to very severe in such infants (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). The phenomenon of persistence of transplacentally acquired maternal lymphocytes is particularly important for several other reasons: 1) there may be no lymphopenia to suggest a diagnosis of SCID, 2) if a donor for bone marrow transplantation (BMT) other than the mother is chosen, the question arises as to whether pretransplant conditioning is needed to suppress rejection of the third party cells by the maternal T cells, and 3) if a BMT donor other than the mother is chosen, the potential for a graft versus graft (GVG) reaction exists when donor marrow T cells recognize the prenatally acquired maternal cells.…”

mentioning

confidence: 99%

Graft versus graft and graft versus host reactions after HLA‐identical bone marrow transplantation in a patient with severe combined immunodeficiency with transplacentally acquired lymphoid chimerism

Friedman

Shiff

Ward

et al. 1991

Pediatric Allergy Immunology

View full text Add to dashboard Cite

We describe a patient with severe combined immunodeficiency and transplacental transfer of maternal T cells who received an unfractionated HLA‐identical sibling bone marrow transplant without prior conditioning. He presented prior to transplantation with a dermatitis later diagnosed as mild graft versus host disease. He had a normal absolute lymphocyte count, but proliferative responses to mitogens were very low. Antigens of the noninherited maternal HLA haplotype were detected on his blood lymphocytes. After transplantation, he developed a severe reaction including fever, cutaneous erythema and hepatosplenomegaly. Lymphocytes carrying the noninherited maternal HLA haplotype disappeared from his circulation, and his unprimed mononuclear cells became spontaneously cytotoxic to maternal lymphoblasts. He subsequently developed a lymphocytosis of 69,000/mm3, diarrhea, elevated transaminases and a worsening rash, necessitating treatment with immunosuppressive agents. Full T‐cell engraftment and evidence of B‐cell function later ensued and spontaneously cytotoxic lymphocytes against maternal cells disappeared by 47 days post‐transplantation. We postulate that the patient's constellation of signs and symptoms after transplantation represented a combination of severe graft versus graft and mild graft versus host reactions.

show abstract

“…The passage of cells from mother to fetus is not as well documented, but maternal lymphocytes and erythro cytes have been firmly identified in some human newborns. Engraftment of maternal lymphocytes has been observed in 25% of infants suffering from combined severe immune de ficiency [16], and it may lead to a graft-vs.-host disease in some of these infants [17][18][19]. The path by which T lympho cytes attain the vascular compartment of the fetus is un known but one can speculate that these mobile and infil trating cells could follow other placental routes than breaks in the vasculo syncytial membrane.…”

Section: Mother To Fetus Transfer Of Red Blood Cellsmentioning

confidence: 99%

Maternal-Fetal Hemorrhage: A Reappraisal

Brossard¹,

Pons²,

Jrad³

et al. 1996

Vox Sanguinis

View full text Add to dashboard Cite

To determine the frequency of maternal-fetal hemorrhage at or above 1 μl of maternal whole blood. Methods: Seventy-three mothers whose red blood cells bore an Rh antigen (Rh D, Rh c, Rh E) that was absent on red blood cells of their newborns were identified and a new cytological method, the Kleihauerimmunogold- silver-staining technique, was applied on the blood of their neonates to detect and quantify maternal red blood cells. Stringent precautions were taken to avoid contaminations of neonatal blood samples by adult red blood cells. Results: Maternal red blood cells were present in 3 newborns, a frequency of 4% (95% Cl: 1-11%), and the estimated volumes of hemorrhage were 0.8, 1.5, and 101 μl of maternal whole blood. No obstetric factor was clearly associated in this limited study with the occurrence of maternal-fetal hemorrhage. Conclusions: Mother-to-fetus microtransfusion greater than 1 μl is infrequent at or near delivery, and it may be observed after an uncomplicated pregnancy and vaginal delivery.

show abstract

Nature of reconstitution with histoincompatible maternal marrow in a case of severe combined immunodeficiency with graft-versus-host disease following maternofetal transfusion

Cited by 7 publications

References 23 publications

Maternal‐Fetal Hemorrhage: A Reappraisal

Maternal‐Fetal Hemorrhage: A Reappraisal

Graft versus graft and graft versus host reactions after HLA‐identical bone marrow transplantation in a patient with severe combined immunodeficiency with transplacentally acquired lymphoid chimerism

Maternal-Fetal Hemorrhage: A Reappraisal

Contact Info

Product

Resources

About