2006
DOI: 10.1016/j.bone.2005.11.027
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Nature of phosphate substrate as a major determinant of mineral type formed in matrix vesicle-mediated in vitro mineralization: An FTIR imaging study

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Cited by 79 publications
(58 citation statements)
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“…Zhang et al (18) found that iRoot BP Plus significantly up-regulated the activity of alkaline phosphatase (ALP) and the expression of dentin sialophosphoprotein (DSPP), dentin matrix protein-1 (DMP-1), and osteocalcin (OCN) of hDPCs; these genes are associated with mineralization and odontoblastic differentiation (29,30). The enhancement of iRoot BP Plus was also significantly higher than that of MTA (18).…”
Section: Discussionmentioning
confidence: 91%
“…Zhang et al (18) found that iRoot BP Plus significantly up-regulated the activity of alkaline phosphatase (ALP) and the expression of dentin sialophosphoprotein (DSPP), dentin matrix protein-1 (DMP-1), and osteocalcin (OCN) of hDPCs; these genes are associated with mineralization and odontoblastic differentiation (29,30). The enhancement of iRoot BP Plus was also significantly higher than that of MTA (18).…”
Section: Discussionmentioning
confidence: 91%
“…ALP is present in the early differentiation phase and plays an important role in mineral deposition (24). Col I is the predominant collagen in dentin (25) and provides a structural framework for inorganic deposition.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, the application of Fourier transform infrared (FT-IR) microspectroscopy to clinical studies has been focused on the diagnosis of diseases and laboratory analyses of pathological samples, particularly for characterization of the biological mineralization [1,4,16]. In the traditional FT-IR analysis without microscopy, this technique allows identifying any organic or inorganic molecules in the calcified samples by grinding the sample with KBr powder or sealing the sample within two KBr pellets for spectral determination after compression [6,8,11].…”
Section: Introductionmentioning
confidence: 99%