Nature brings new avenues to the therapy of central nervous system diseases—An overview of possible treatments derived from natural products

Zhang, Junchi; Yang, He; Jiang, Xiangrui; Jiang, Hualiang; Shen, Jingshan

doi:10.1007/s11427-019-9587-y

Cited by 26 publications

(15 citation statements)

References 220 publications

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“…This method holds great potential for applications to understand and reconstruct herbal medicine from a molecular level. It may serve as the initial step in the pipeline of natural compound-inspired drug discovery [ 54 ]. Follow-up in vitro and in vivo tests can further confirm and improve these predictions.…”

Section: Discussionmentioning

confidence: 99%

Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach

Lai

2019

Acta Pharmacol Sin

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Chinese herbal medicine (CHM) addresses complex diseases through polypharmacological interactions. However, systematic studies of herbal medicine pharmacology remain challenging due to the complexity of CHM ingredients and their interactions with various targets. In this study, we aim to address this challenge with computational approaches. We investigated the herb-target-disease associations of 197 commonly prescribed CHMs using the similarity ensemble approach and DisGeNET database. We demonstrated that this method can be applied to associate herbs with their putative targets. In the case study of three well-known herbs, Radix Glycyrrhizae, Flos Lonicerae, and Rhizoma Coptidis, approximately 70% of the predicted targets were supported by scientific literature. By linking 406 targets to 2439 annotated diseases, we further analyzed the pharmacological functions of 197 herbs. Finally, we proposed a strategy of target-oriented herbal formula design and illustrated the target profiles for four common chronic diseases, namely, Alzheimer’s disease, depressive disorder, hypertensive disease, and non-insulin-dependent diabetes mellitus. This computational approach holds great potential in the target identification of herbs, understanding the molecular mechanisms of CHM, and designing novel herbal formulas.

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Section: Discussionmentioning

confidence: 99%

Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach

Lai

2019

Acta Pharmacol Sin

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“…Additional studies revealed two new regions of steric repulsive around the 4′-and 5′-regions of the B-ring [61,64]. e chemical constituents responsible for the anxiolytic activity of Passiflora are not yet fully understood but the majority of published works suggest that phenolic substances, especially the flavonoid class, are related to this property [65][66][67][68]. e flavonoids identified in P. incarnata (Figure 1) probably act according to the pharmacophoric models described.…”

Section: Mechanism Of Anxiolytic Actionmentioning

confidence: 96%

Herbal Medicinal Products fromPassiflorafor Anxiety: An Unexploited Potential

Fonseca

Rodrigues

Ramos

et al. 2020

The Scientific World Journal

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Herbal medicines containing Passiflora species have been widely used to treat anxiety since ancient times. The species Passiflora incarnata L. is included in many Pharmacopoeias, and it is the most used species in food, cosmetic, and pharmaceutical industries. However, there are around 600 species of the genus Passiflora and probably other species that can be used safely. Thus, this article was based on a search into the uses of the main species of the genus Passiflora with anxiolytic activity and its main secondary metabolites and some pharmacological studies, patents, and registered products containing Passiflora. Furthermore, the Brazilian Regulatory Health Agency Datavisa, Medicines and Healthcare Products Regulatory Agency of the United Kingdom, and the European Medicines Agency websites were consulted. The results showed that Passiflora species have health benefits but clinical trials are still scarce. The complexity of Passiflora extracts creates challenges for the development of herbal medicines. P. incarnata is the most studied species of the genus and the most used in natural anxiolytic herbal medicine formulations. However, there are hundreds of Passiflora species potentially useful for medicinal and nutraceutical purposes that are still little explored.

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“…Many experiments have indicated that some natural products act simultaneously on multiple targets and pathways and are uniquely advantageous for PAH therapy. More importantly, the novel skeletons, targets, and mechanisms of natural products may provide new inspiration to researchers, which may lead to theoretical innovations in the field of PAH research. − …”

Section: Discussionmentioning

confidence: 99%

Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives

et al. 2020

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Pulmonary arterial hypertension (PAH) is a devastating disease that can lead to right ventricular failure and premature death. Although approved drugs have been shown to be safe and effective, PAH remains a severe clinical condition, and the long-term survival of patients with PAH is still suboptimal. Thus, potential therapeutic targets and new agents to treat PAH are urgently needed. In recent years, a variety of related pathways and potential therapeutic targets have been found, which brings new hope for PAH therapy. In this perspective, not only are the marketed drugs used to treat PAH summarized but also the recently developed novel pharmaceutical therapies currently in clinical trials are discussed. Furthermore, the advances in natural products as potential treatment for PAH are also updated.

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Nature brings new avenues to the therapy of central nervous system diseases—An overview of possible treatments derived from natural products

Cited by 26 publications

References 220 publications

Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach

Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach

Herbal Medicinal Products fromPassiflorafor Anxiety: An Unexploited Potential

Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives

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