Nature and vocational significance of neuropsychological impairment associated with HIV infection

Heaton, Robert K.; Marcotte, Thomas D.; White, Desirée A.; Ross, David Gaddis; Meredith, Keith; Taylor, Michael J.; Kaplan, Robert M.; Grant, Igor

doi:10.1080/13854049608406658

Cited by 58 publications

(46 citation statements)

References 36 publications

(27 reference statements)

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“…This study supports and extends previous reports regarding the everyday life significance of NP impairments associated with HIV infection (Albert et al, 1995;Heaton et al, 1996;Hinkin et al, 2002;Marcotte et al, 1999;Stern et al, 1991). It is the largest such study to date and the most comprehensive in its coverage of both performance-based measures of IADLs and manifest measures of daily functioning outside of the laboratory.…”

Section: Discussionsupporting

confidence: 89%

“…In addition to the above IADL tasks, we utilized information gathered from work histories and a series of objective, criterion-referenced vocational tests as part of the Vocational Assessment. Together, these two types of information can be used to determine whether participants evidence poorer performance on measures of current vocational functioning than would be expected based upon their prior work histories (Heaton et al, 1996).…”

Section: Functional Evaluationmentioning

confidence: 99%

“…They are therefore distinct from typical neuropsychological tests measuring similar constructs in that they are not based on normative data but on a specific criterion, and the outcome scores are designed to conform to DOT profile scores rather than standardized scores that might correct for one or more demographic variables. For the purposes of this paper, the functional levels for the Aptitudes and GED abilities were summed in order to calculate a Work Assessment Total Score to provide an overall index of vocational ability (Heaton et al, 1996). Manifest Functioning is defined as self-report of everyday functioning outside of the laboratory.…”

Section: Functional Evaluationmentioning

confidence: 99%

“…At present, the few available studies concerning functional impact of HIV-related NP deficits suggest that these deficits are associated with impaired driving ability, worse performance on standardized work samples, increased unemployment and complaints of problems in vocational functioning and everyday living (Albert et al, 1995;Benedict et al, 2000;Heaton et al, 1996;Mapou et al, 1993;Marcotte et al, 1999;Stern et al, 1991). Of particular importance to HIV1 patients is the ability to effectively manage their antiretroviral medications.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The impact of HIV-associated neuropsychological impairment on everyday functioning

Heaton

Marcotte

Mindt

et al. 2004

J. Inter. Neuropsych. Soc.

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678

689

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HIV-1 infection can be associated with neuropsychological (NP) deficits ranging from subtle to severe. The purpose of this study was to evaluate the functional, or "real-world" impact of HIV-associated NP impairment in a group of 267 HIV-infected participants. All participants received comprehensive NP, neuromedical, and standardized functional evaluations that included laboratory measures of shopping, cooking, financial management, medication management and vocational abilities. Compared to NP-normal participants, those with NP impairment performed significantly worse on all laboratory measures of everyday functioning. Multivariate analyses revealed that the NP ability domains of Abstraction0Executive Function, Learning, Attention0Working Memory and Verbal abilities most strongly and consistently predicted failures on the functional battery. Both NP impairment and impairment on the functional battery were significantly associated with subjective experiences of cognitive difficulties, as well as unemployment and increased dependence in activities of daily living; multivariate prediction models that also considered depressed mood and biological measures of disease progression revealed that impairment on the functional battery and depression were the only unique predictors of all three indicators of "real-world" functioning. The current results add to growing evidence concerning the clinical significance of HIV-associated NP impairment. Objective, laboratory based functional measures, such as those used here, may compliment NP testing in future studies directed at understanding the impact on life quality of central nervous system disorders and their treatments. Finally, there is a need for additional research investigating the apparently independent effect of depression on level of everyday functioning in HIV infected persons. (JINS, 2004, 10, 317-331.)

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Section: Discussionsupporting

confidence: 89%

Section: Functional Evaluationmentioning

confidence: 99%

Section: Functional Evaluationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The impact of HIV-associated neuropsychological impairment on everyday functioning

Heaton

Marcotte

Mindt

et al. 2004

J. Inter. Neuropsych. Soc.

Self Cite

678

689

View full text Add to dashboard Cite

show abstract

“…In a later study, Heaton, et al (1996) described the nature and consequences of neuropsychological impairment in HIV infection. The study found that neuropsychological impairment increases or advances along with HIV disease progression.…”

Section: Hiv/aids Neuropsychological Functioning and Employmentmentioning

confidence: 99%

Neuropsychiatric predictors of occupational persistence in HIV/AIDS.

Buckingham¹

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HIV Disease and Work: Effect on the Individual, Workplace, and Interpersonal Contexts

Hoffman

1997

Journal of Vocational Behavior

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Nature and vocational significance of neuropsychological impairment associated with HIV infection

Cited by 58 publications

References 36 publications

The impact of HIV-associated neuropsychological impairment on everyday functioning

The impact of HIV-associated neuropsychological impairment on everyday functioning

Neuropsychiatric predictors of occupational persistence in HIV/AIDS.

HIV Disease and Work: Effect on the Individual, Workplace, and Interpersonal Contexts

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