Nature and Healing of Tibial Shaft Fractures in Alcohol Abusers

Nyquist, Fredrik; Berglund, Mats; Nilsson, Bo; Obrant, Karl

doi:10.1093/oxfordjournals.alcalc.a008240

Cited by 58 publications

(39 citation statements)

References 21 publications

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“…The limited available data suggest that alcoholism does not increase the incidence of nonunions, osteonecrosis, or other complications (Nyquist et al, 1997(Nyquist et al, , 1998 but is associated with an increase in healing time for transverse fractures (Nyquist et al, 1997).…”

Section: Effects Of Alcohol Abuse On Bone Mass and Fracture Incidencementioning

confidence: 98%

Skeletal Response to Alcohol

Turner

2000

Alcoholism Clin & Exp Res

195

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This review briefly assesses the well-established effects of alcohol consumption on bone and mineral metabolism and addresses areas of controversy that need additional research. Alcohol consumption is a risk factor for osteoporosis based on the frequent finding of a low bone mass, decreased bone formation rate, and increased fracture incidence in alcoholics. Alcohol also has been shown to reduce bone formation in healthy humans and animals and to decrease proliferation of cultured osteoblastic cells. On the other hand, it has been difficult to demonstrate alcohol-induced bone loss and increased fracture rate in population-based studies. Indeed, most population-based studies have shown a positive association between alcohol and bone mass and no change or a decrease in fracture risk. Overall, the evidence generally supports a detrimental effect of chronic alcohol abuse on the skeleton of men and a neutral or generally beneficial effect of light to moderate alcohol consumption, especially in older women. This latter putative beneficial effect may be due to a reduction in the age-related increase in bone remodeling associated with postmenopausal bone loss. Specific areas of research are recommended to clarify the dose and sex effects of alcohol consumption and to determine cellular and molecular mechanisms of action. The goals of this proposed research emphasis are to determine the degree of risk for the range of alcohol consumption, to set guidelines of consumption compatible with maintaining bone health, and to develop appropriate countermeasures to prevent or reverse the detrimental skeletal effects of alcohol abuse.

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Section: Effects Of Alcohol Abuse On Bone Mass and Fracture Incidencementioning

confidence: 98%

Skeletal Response to Alcohol

Turner

2000

Alcoholism Clin & Exp Res

195

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“…Intoxication increases risks for both sustaining fracture injuries as well as adversely affecting the healing process. Human studies have shown that healing and recovery from fractures is adversely affected and is prolonged with higher rates of complications in patients with significant EtOH exposure (3,23,24).…”

Section: Discussionmentioning

confidence: 99%

“…Among the numerous physiological effects of alcohol exposure, it has been widely shown that alcohol interferes with bone formation and fracture healing. Patients who abuse alcohol have prolonged healing time following transverse tibial fractures (3).…”

mentioning

confidence: 99%

Alcohol Inhibits Osteopontin-dependent Transforming Growth Factor-β1 Expression in Human Mesenchymal Stem Cells

Driver

Weber

Callaci

et al. 2015

Journal of Biological Chemistry

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Background: Alcohol (EtOH) exposure has detrimental effects on fracture healing. Results: EtOH inhibits TGF-␤1 protein expression via interference with the transcription factor myeloid zinc finger 1. Conclusion: EtOH-induced deficient fracture healing may be related to reduced TGF-␤1. Significance: Further understanding of the mechanisms responsible for the effects of EtOH are crucial for the development of interventions aimed at averting morbidities related to EtOH consumption.

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“…The limited available data suggest that alcoholism does not lead to an increase in the incidence of nonunions, osteonecrosis or other complications (Nyquist et al, 1997;Nyquist et al, 1998), but is associated with an increase in healing time for transverse fractures (Nyquist et al, 1997).…”

Section: Effects Of Alcohol Abuse On Bone Mass and Fracture Incidencementioning

confidence: 99%

Alcohol and Adaptation to Mechanical Usage

Turner¹

2000

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget, Paperwork Reduction Project (0704-0188), Washington, DC 20503 AGENCY USE ONLY (Leave blank) REPORT DATE October 2000 REPORT TYPE AND DATES COVEREDAnnual (1 Sep 99 -31 Aug 00) TITLE AND SUBTITLE Alcohol and Adaptation to Mechanical Usage AUTHOR(S)Russell T. Turner, Ph.D. FUNDING NUMBERS DAMD17-98-1-8517 PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES)Mayo Foundation Rochester, Minnesota 55905 E-MAIL: rolbiecki.lori@mayo.edu These studies are designed to determine whether ethanol antagonizes the ability of the skeleton to adapt to increased mechanical usage. Ethanol reversibly alters the biophysical properties of cell membranes.The overall hypothesis to be tested in adult rats is that these membrane changes disrupt essential cell signaling pathways for one or more cytokines, growth factors and polypeptide hormones that regulate bone modeling and remodeling.This report summarizes our progress from 01 September 1999 to 31 August 2000. During Year 2 of the award we have continued analysis of experiments performed in Year 1 related to Tasks 1-4 and 8.Additional experiments were performed to accomplish Task 8. Progress was also made on Tasks 6, 7, and 8.The new studies are directed toward determination of the effects of ethanol on: the skeletal readaptation to normal weight bearing following unloading (Task 6), skeletal adaptation to treadmill running (Task 7), PTH-induced increases in mRNA levels for bone matrix proteins (Task 8), and PTH-induced increases in osteoblast number and bone formation (Task 9). SUBJECT TERMS Neurotoxin NUMBER OF PAGES INTRODUCTIONChronic alcohol abuse is an important risk factor for osteoporosis. The ultimate goal of this research is to identify the cellular and molecular mechanisms responsible for mediating ethanol's dose-and time-dependent actions on bone turnover, mass, architecture, and strength. It is well established that ethanol reversibly alters the biophysical properties of cell membranes and in doing so disturbs normal membrane function. The proposed studies in young adult rats will test our working hypothesis that these membrane changes disrupt essential cell signaling pathways for one or more bone cells "coupling" factors and/or polypeptide hormones that regulate bone modeling and remodeling. These changes are postulated to lead to the bone loss associated with chronic alcohol abuse. If our hypothesis is correct, then ethanol antagonizes the ability of t...

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Nature and Healing of Tibial Shaft Fractures in Alcohol Abusers

Cited by 58 publications

References 21 publications

Skeletal Response to Alcohol

Skeletal Response to Alcohol

Alcohol Inhibits Osteopontin-dependent Transforming Growth Factor-β1 Expression in Human Mesenchymal Stem Cells

Alcohol and Adaptation to Mechanical Usage

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