Nature and applications of scorpion venom: an overview

Tobassum, Saadia; Tahir, Hafız Muhammad; Arshad, Muhammad; Zahid, Muhammad; Ali, Shaukat; Ahsan, Muhammad Mohsin

doi:10.1080/15569543.2018.1530681

Cited by 14 publications

(18 citation statements)

References 117 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fig. 4 displays the mechanism of K + channel activity in open/closed state as well as N-or C-type inactivation [71].…”

Section: The Action Of Toxins On Various Ion Channelsmentioning

confidence: 99%

See 1 more Smart Citation

Potential of Scorpion Venom for the Treatment of Various Diseases

JAVED¹,

Hussain²,

KHAN³

et al. 2022

Int J Chem Res

View full text Add to dashboard Cite

The venom of various scorpion species finds significant therapeutic applications. It is rich in neurotoxins, enzymes, enzyme inhibitors, histamine, lipids and different salts from which peptides demonstrate a great potential against a variety of diseases. Many biological functions e. g., bradykinin potentiating, hemolytic, anti-cancer, anti-microbial, and anti-inflammatory potential are being regulated by non-disulfide-bonded peptides. Therefore, it is motivating to use these properties for the treatment of cancer, cardiovascular diseases, diabetes, AIDS, apoplexy, influenza H5N1, paralysis, epilepsy, malaria, measles, severe combined immunodeficiency, fever blisters and diabetes. Scorpion venom has shown the presence of 100,000 bioactive compounds but only 1 % of these have been purified, isolated and characterized by HPLC and mass spectroscopy etc. For the production of high-quality antivenom with specific antibodies, gentler electrical stimulation is a better method as compared to manual production. Recombinant DNA technology has facilitated the identification of new components. Some important medicinal compounds isolated from scorpion venom include HsTX1 (from Heterometrus spinnifer), mucroporin-M1 (from Lychas mucronatus), chlorotoxin and charybdotoxin (from Leiurus quinquestriatus hebraeus). B. leptochelys venom has shown the presence of at least 148 components. Six novel long-chain peptides were isolated from the scorpion Buthus martensi Karsch venom. Crude venom of L. Abdullah bayrami displays a proliferative effect on MCF-7 cells and also shows antimicrobial potential. A new toxin derived from the venom of Liocheles waigiensis [U1-liotoxin-Lw1a (U1-LITX-Lw1a)] displays significant insecticidal action. The computational studies may play an important role while developing ion channel drugs from venom peptides.

show abstract

“…Fig. 4 displays the mechanism of K + channel activity in open/closed state as well as N-or C-type inactivation [71].…”

Section: The Action Of Toxins On Various Ion Channelsmentioning

confidence: 99%

“…The venom of Leiurus quinquestriatus with alkaloid neurotoxins causes synergistic effects to regulate the action potential. When scorpion toxins are attached to receptors on dopaminergic neurons, then release of dopamine is observed, which may be effective for curing of Parkinson's disease [71].…”

Section: Potential Against Epilepsymentioning

confidence: 99%

Potential of Scorpion Venom for the Treatment of Various Diseases

JAVED¹,

Hussain²,

KHAN³

et al. 2022

Int J Chem Res

View full text Add to dashboard Cite

show abstract

“…Scorpion venom is a mixture of various peptides including some enzymes like, phospholipases, alkaline phosphatases, hyaluronidases, acetylcholinesterase's, sphingomyelinases and proteolytic enzymes, neurotransmitters, amino acids, ions and low molecular weight peptides (less than 10 KDa) (Ortiz et al, 2015). The scorpion venoms are used to cure different diseases like acute and chronic convulsions, cardiovascular diseases, epilepsy, tetanus, subcutaneous nodules, human immunodeficiency virus (HIV), human leukemia cell lines, male impotency, kidney tumor, brain tumor, breast cancer, prostate tumor, skin cancers, rheumatism and pancreatitis (Nabi et al, 2015;Attarde and Pandit, 2016;Tobassum et al, 2020). As mentioned above scorpion venoms are very effective for the treatment of various types of cancer cells (Rapôso, 2017).…”

Section: Research Articlementioning

confidence: 99%

Iranian Mesobuthus Eupeus Crude Venom Induces Selective Toxicity in Chronic Lymphocytic Leukemia B-Lymphocytes Through Lysosomal/Mitochondrial Dysfunction and Reactive Oxygen Species Formation

Salimi

Adhami

Alehashem

et al. 2022

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

“…Nearly 1.5 million scorpion envenomations are registered annually in the world ( Ahmadi et al, 2020 ). These animals are represented by more than 2200 species and belong to the Phylum Arthropoda , Class Arachnida and Order Scorpiones ( Tobassum et al, 2020 ). The vast majority of scorpion species harmful to humans are members of the Buthidae family.…”

Section: Introductionmentioning

confidence: 99%

Cytokines and their regulators in rat lung following scorpion envenomation

Gunas,

Maievskyi,

Synelnyk

et al. 2024

Toxicon: X

View full text Add to dashboard Cite

Nature and applications of scorpion venom: an overview

Cited by 14 publications

References 117 publications

Potential of Scorpion Venom for the Treatment of Various Diseases

Potential of Scorpion Venom for the Treatment of Various Diseases

Iranian Mesobuthus Eupeus Crude Venom Induces Selective Toxicity in Chronic Lymphocytic Leukemia B-Lymphocytes Through Lysosomal/Mitochondrial Dysfunction and Reactive Oxygen Species Formation

Cytokines and their regulators in rat lung following scorpion envenomation

Contact Info

Product

Resources

About