Naturally Occurring Variability in Anesthetic Potency Among Inbred Mouse Strains

Sonner, James M.; Gong, Diane; Eger, Edmond I.

doi:10.1213/00000539-200009000-00042

Cited by 100 publications

(40 citation statements)

References 20 publications

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“…Direct dose-dependent vasodilation by isoflurane has been shown in isolated coronary microvessels (31), but other authors have found a vasoconstricting effect on coronary arterioles (32). The comparison between ifl and kx provided here showed that MBF remained within physiologic ranges at 1.25% ifl and that a substantial vasodilation only occurred at ifl concentrations above 1.25%, which approximately corresponds to the minimum alveolar concentration for this animal strain (33). The concentration cycle measurement was performed on only two animals, but it confirmed that MBF reversibly depends on ifl concentration.…”

Section: Fig 1 Global Inversion T 1 Map (A)mentioning

confidence: 45%

Myocardial blood flow mapping in mice using high‐resolution spin labeling magnetic resonance imaging: Influence of ketamine/xylazine and isoflurane anesthesia

Kober

Iltis

Cozzone

et al. 2005

Magnetic Resonance in Med

106

140

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Genetically modified mouse models of many human diseases reflecting cardiovascular alterations are currently available. To date, little information on absolute myocardial perfusion in mice is found in the literature. High-resolution quantitative myocardial blood flow maps (in-plane resolution 156 ؋ 312 m 2 , slice thickness 1.5 mm) have been obtained noninvasively within 25 min at 4.7 T in 30 freely breathing C57/Bl6J mice using electrocardiogram-and respiration-gated spin labeling magnetic resonance imaging (MRI). Regional myocardial blood flow measurements were carried out, and the effects of isoflurane at two different concentrations and ketamine/xylazine anesthesia were assessed. The mean blood flow value in the left ventricular myocardium was 6.0 ؎ 1.9 mL g ؊1 min ؊1 under ketamine/ xylazine and 6.9 ؎ 1.7 mL g ؊1 min ؊1 (group average ؎ SD) under isoflurane (1.25%). Under the influence of higher isoflurane concentration (2.00%), myocardial blood flow increased dramatically to 16.9 ؎ 1.8 mL g ؊1 min ؊1 with no significant change in heart rate. This work illustrates the feasibility of noninvasive quantitative myocardial perfusion mapping in mice using MRI. The study of the influence of anesthesia shows that myocardial blood flow is highly sensitive to isoflurane concentration. The method employed offers a noninvasive approach to longitudinal studies of murine models of cardiac disease. Magn Reson Med 53:601-606, 2005.

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Section: Fig 1 Global Inversion T 1 Map (A)mentioning

confidence: 45%

Myocardial blood flow mapping in mice using high‐resolution spin labeling magnetic resonance imaging: Influence of ketamine/xylazine and isoflurane anesthesia

Kober

Iltis

Cozzone

et al. 2005

Magnetic Resonance in Med

106

140

View full text Add to dashboard Cite

show abstract

“…Conversely, during in vivo measurement of cardiac function, mice were constantly anesthetized with isoflurane. Isoflurane has been shown to have strain-dependent cardiodepressive effects in vivo (8,9,28,30,46). Additionally, isoflurane anesthesia has been shown to be cardioprotective from ischemic injury through mechanisms that are not fully understood but are thought to mimic ischemic preconditioning (25).…”

Section: Discussionmentioning

confidence: 99%

Influence of genetic background on ex vivo and in vivo cardiac function in several commonly used inbred mouse strains

Barnabei

Palpant

Metzger

2010

Physiological Genomics

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“…MAC values for desflurane, halothane, and isoflurane were measured as described previously (Sonner et al, 2000).…”

Section: Methodsmentioning

confidence: 99%

α1 Subunit-Containing GABA Type A Receptors in Forebrain Contribute to the Effect of Inhaled Anesthetics on Conditioned Fear

Sonner¹,

Cascio²,

Xing³

et al. 2005

Mol Pharmacol

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Inhaled anesthetics are believed to produce anesthesia by their actions on ion channels. Because inhaled anesthetics robustly enhance GABA A receptor (GABA A -R) responses to GABA, these receptors are considered prime targets of anesthetic action. However, the importance of GABA A -Rs and individual GABA A -R subunits to specific anesthetic-induced behavioral effects in the intact animal is unknown. We hypothesized that inhaled anesthetics produce amnesia, as assessed by loss of fear conditioning, by acting on the forebrain GABA A -Rs that harbor the ␣1 subunit. To test this, we used global knockout mice that completely lack the ␣1 subunit and forebrain-specific, conditional knockout mice that lack the ␣1 subunit only in the hippocampus, cortex, and amygdala. Both knockout mice were 75 to 145% less sensitive to the amnestic effects of the inhaled anesthetic isoflurane. These results indicate that ␣1-containing GABA A -Rs in the hippocampus, amygdala, and/or cortex influence the amnestic effects of inhaled anesthetics and may be an important molecular target of the drug isoflurane.

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Naturally Occurring Variability in Anesthetic Potency Among Inbred Mouse Strains

Cited by 100 publications

References 20 publications

Myocardial blood flow mapping in mice using high‐resolution spin labeling magnetic resonance imaging: Influence of ketamine/xylazine and isoflurane anesthesia

Myocardial blood flow mapping in mice using high‐resolution spin labeling magnetic resonance imaging: Influence of ketamine/xylazine and isoflurane anesthesia

Influence of genetic background on ex vivo and in vivo cardiac function in several commonly used inbred mouse strains

α1 Subunit-Containing GABA Type A Receptors in Forebrain Contribute to the Effect of Inhaled Anesthetics on Conditioned Fear

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