Naturally occurring protein nano compartments: basic structure, function, and genetic engineering

Goel, Dimple; Sinha, Sharmistha

doi:10.1088/2632-959x/ac2c93

Cited by 3 publications

(4 citation statements)

References 104 publications

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“…Hollow protein containers are widespread in nature and include not only viral capsids but also nanocages of bacterial or eukaryotic origin [91][92][93][94]. Their inner and outer surfaces can be modified chemically or genetically, and the internal cavity can be used to template, store, and/or arrange molecular cargos [5].…”

Section: Structural Studies For the Characterization Of Virus-based N...mentioning

confidence: 99%

Physical Virology in Spain

Reguera,

de Pablo,

Abrescia

et al. 2023

Biophysica

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Virus particles consist of a protein coat that protects their genetic material and delivers it to the host cell for self-replication. Understanding the interplay between virus structure and function is a requirement for understanding critical processes in the infectious cycle such as entry, uncoating, genome metabolism, capsid assembly, maturation, and propagation. Together with well-established techniques in cell and molecular biology, physical virology has emerged as a rapidly developing field, providing detailed, novel information on the basic principles of virus assembly, disassembly, and dynamics. The Spanish research community contains a good number of groups that apply their knowledge on biology, physics, or chemistry to the study of viruses. Some of these groups got together in 2010 under the umbrella of the Spanish Interdisciplinary Network on Virus Biophysics (BioFiViNet). Thirteen years later, the network remains a fertile ground for interdisciplinary collaborations geared to reveal new aspects on the physical properties of virus particles, their role in regulating the infectious cycle, and their exploitation for the development of virus-based nanotechnology tools. Here, we highlight some achievements of Spanish groups in the field of physical virology.

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Section: Structural Studies For the Characterization Of Virus-based N...mentioning

confidence: 99%

Physical Virology in Spain

Reguera,

de Pablo,

Abrescia

et al. 2023

Biophysica

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“…1 Ferritin and its homologs, bacterial microcompartments (BMCs), lumazine synthase, vault complex, and encapsulin are some examples of lipid-free proteinaceous compartments involved in various cell functions. [2][3][4][5][6][7] Ferritin is the first discovered protein compartment and is involved in the iron storage and homeostasis of iron. 8 It is present in both eukaryotic and prokaryotic cells.…”

Section: Introductionmentioning

confidence: 99%

“…In past few years, they have been utilized to fabricate novel materials with a wide range of applications. 2,[12][13][14][15][16][17] Fig. 1 chronologically summarizes the discovery and the first attempt towards the application of these naturally occurring protein compartments.…”

Section: Introductionmentioning

confidence: 99%

Innate and engineered attributes of bacterial microcompartments for applications in bio-materials science

Sinha¹,

Rose²,

Radhakrishnan³

2023

J. Mater. Chem. B

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“…1 In nature, protein cage-based nanocompartments are commonly found in eukaryotes and prokaryotes. 2 These complex supramolecular systems are assembled from multiple copies of single or various protein monomers, providing a unique enclosed space for enzyme sequestration. 3 For instance, encapsulins, as bacterial organelle-like compartments, encompass one or more types of cargo proteins involved in diverse aspects of metabolism.…”

Section: Introductionmentioning

confidence: 99%