Naturally Occurring Plectranthus-derived Diterpenes with Antitumoral Activities

García, Catarina; Teodósio, Catarina; Oliveira, Carolina; Oliveira, Claúdia; Díaz-Lanza, Ana María; Reis, Catarina Pinto; Duarte, Noélia; Rijo, Patrícia

doi:10.2174/1381612825666190115144241

Cited by 18 publications

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“…The compound Diroy is the less bioactive abietane and this is in agreement with the more polar feature on the C-6 and C-7 positions. This polar structure-activity relationship could be explained due to a better membrane interaction [11][12][13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 98%

“…Numerous studies attribute these biological properties to the diterpenes expressed by this genus [8][9][10]. Our previous studies have demonstrated that the diterpenes isolated from Plectranthus genus induce apoptosis in various cancer cell lines, including human myeloid leukaemia, and pancreatic, lung, melanoma, prostate, and breast cancer [11][12][13][14][15][16][17]. The present study focuses on the properties of abietane diterpenes (Roy, Deroy, Diroy, and Parv D) isolated from P. madagascariensis and P. ecklonii.…”

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confidence: 96%

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Insight the Biological Activities of Selected Abietane Diterpenes Isolated from Plectranthus spp.

et al. 2020

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Natural compounds isolated from plants are excellent starting points in drug design and have been widely studied as anticancer agents; they hence find use in a considerable proportion of anticancer drugs. The genus Plectranthus (Lamiaceae) comprises a large and widespread group of species with various applications in traditional medicine. Therefore, the aim of the present study was to determine the effectiveness of treatment with four abietane diterpenoids isolated from P. madagascariensis and P. ecklonii, 6,7-dehydroroyleanone, 7β,6β-dihydroxyroyleanone, 7α-acetoxy-6β-hydroxyroyleanone and parvifloron D, in initiating apoptosis in a glioma cell line. The pure compounds were found to exhibit anticancer effects in primary H7PX glioma cells line by inducing apoptosis G2/M cell cycle arrest and double-strand breaks, indicated by increased levels of phosphorylated H2A.X and decreasing mitochondrial membrane potential; they also influenced the expression of pro- and anti-apoptotic genes (Bax, Bcl-2, TP53, or Cas-3). Our findings indicate that these compounds may offer potential as beneficial antitumor drugs but further in vivo studies are needed.

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Section: Discussionmentioning

confidence: 98%

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confidence: 96%

Insight the Biological Activities of Selected Abietane Diterpenes Isolated from Plectranthus spp.

et al. 2020

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“…Most of the Plectranthus species are soft trailing semi-succulent to succulent herbs or shrubs and their stems, leaves, roots, and tubers are frequently used as traditional medicines for the treatment of various illnesses, including respiratory, digestive, and liver ailments [ 9 ]. Phytochemical studies on some species of Plectranthus revealed the presence of a large number of diterpenes and triterpenes [ 10 , 11 ]. Isolated terpenes from Plectranthus species are reported to possess antibacterial [ 12 , 13 , 14 ], antitumoral [ 15 , 16 , 17 , 18 ], antifungal [ 12 , 19 ], insecticidal [ 20 ], and antiplasmodial [ 20 ] activities.…”

Section: Introductionmentioning

confidence: 99%

“…To the best of our knowledge, the scientific literature concerning these species is scarce or even non-existent. P. hadiensis was earlier reported to have ethnopharmacological activity and to be a rich source of ent-abietane diterpenes [ 11 ]. This work aims to screen the antimicrobial, antioxidant, and cytotoxic properties of several Plectranthus spp.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Biological Activity Screening of Plectranthus spp. Extracts for the Search of Anticancer Lead Molecules

et al. 2021

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Plectranthus species (Lamiaceae) have been employed in traditional medicine and this is now validated by the presence of bioactive abietane-type diterpenoids. Herein, sixteen Plectranthus acetonic extracts were prepared by ultrasound-assisted extraction and their biological activity was screened. The antimicrobial activity of each extract was screened against yeasts, and Gram-positive and Gram-negative bacteria. The P. hadiensis and P. mutabilis extracts possessed significant activity against Staphylococcus aureus and Candida albicans (microdilution method). Moreover, all extracts showed antioxidant activity using the DPPH method, with P. hadiensis and P. mutabilis extracts having the highest scavenging activities. Selected by the Artemia salina model, P. hadiensis and P.ciliatus possessed low micromolar anti-proliferative activities in human colon, breast, and lung cancer cell lines. Furthermore, the most bioactive extract of P. hadiensis leaves and the known abietane diterpene, 7α-acetoxy-6β-hydroxyroyleanone isolated from this plant, were tested against the aggressive type triple negative breast cancer (MDA-MB-231S). P. hadiensis extract reduced the viability of MDA-MB-231S cancer cell line cells, showing an IC50 value of 25.6 µg/mL. The IC50 value of 7α-acetoxy-6β-hydroxyroyleanone was 5.5 µM (2.15 µg/mL), suggesting that this lead molecule is a potential starting tool for the development of anti-cancer drugs.

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“…It has been suggested that the oxidation level of the abietane ring affects the antiproliferative selectivity of the compound. When compared to parviflorone D ( Salim et al, 2008 ), parviflorone F ( Srancikova et al, 2013 ) demonstrated higher cytotoxicity in Vero cell lines ( Garcia et al, 2019 ).…”

Section: Biological Activities Of Isolated Compounds From P Ecklonii Benthmentioning

confidence: 99%

Plectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities

et al. 2021

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Ethnopharmacological Relevance:Plectranthus genus (Lamiaceae family) contain several species with acknowledged ethnopharmacological uses, such as, for gastrointestinal and respiratory-related problems, due to their anti-inflammatory, antibacterial and antifungal properties. The bioactivity of isolated medicinal compounds from this genus justifies the increased interest in recent times for species of Plectranthus, placing them in the spotlight for natural product drug development.Aim of the study: To the best of our knowledge, this is the first review on the biological activities of Plectranthus ecklonii Benth. As such, the aim of this review was three-fold: 1) to summarize the chemical compounds isolated from P. ecklonii; 2) to collate the biological activities and mechanisms of action of these compounds from in vitro studies; and 3) to evaluate the documented uses and potential applications of this species, in order to postulate on the direction of pharmaceutical uses of this species.Materials and methods: An extensive database retrieval was performed using the electronic databases Web of Science, PubMed, Google Scholar and ScienceDirect. The search criteria consisted of the keywords “Plectranthus ecklonii”, “Plectranthus ecklonii + review”, “Plectranthus ecklonii + diterpenes” or “Plectranthus ecklonii + abietanes”, “ecklonii + parviflorone D”, searched individually and as combinations. Eligibility criteria were set out and titles in English, Portuguese and Spanish were reviewed, with all references included dating from 1970 to 2021. A total of 169 papers were selected and included. Chemical structures were drawn using ChemDraw 20.0, CID numbers were searched in PubChem and the PRISMA diagram was created using PowerPoint 2012.Results: To date, a total of 28 compounds have been isolated from P. ecklonii, including diterpenes, triterpenes, flavonoids, and hydroxycinnamic acids. Most focused on the antimicrobial action of its constituents, although compounds have demonstrated other bioactivities, namely antioxidant, anti-inflammatory and antitumor. The most recent studies emphasize the diterpenoids, particularly parviflorone D, with the help of nanotechnology.Conclusions: The widespread ethnobotanical and traditional uses of P. ecklonii can be scientifically justified by a range of biological activities, demonstrated by isolated secondary metabolites. These bioactivities showcase the potential of this species in the development of economically important active pharmaceutical ingredients, particularly in anticancer therapy.

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Naturally Occurring Plectranthus-derived Diterpenes with Antitumoral Activities

Cited by 18 publications

References 0 publications

Insight the Biological Activities of Selected Abietane Diterpenes Isolated from Plectranthus spp.

Insight the Biological Activities of Selected Abietane Diterpenes Isolated from Plectranthus spp.

Preliminary Biological Activity Screening of Plectranthus spp. Extracts for the Search of Anticancer Lead Molecules

Plectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities

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