Naturally occurring phenolic compounds as promising antimycotoxin agents: Where are we now?

Ahmed, Omar S.; Tardif, Charles; Rouger, Caroline; Atanasova‐Pénichon, Vessela; Richard‐Forget, Florence; Waffo-Téguo, Pierre

doi:10.1111/1541-4337.12891

Cited by 20 publications

(21 citation statements)

References 216 publications

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“…Ferulic acid, a methylated form of caffeic acid, could also affect the growth of toxigenic A. flavus [12]. Ahmed et al [14] recently reviewed the mechanisms involved in antifungal and antimycotoxin action of phenolic compounds. They include the following: fungal membrane modifications affecting permeability and functioning, reduction in oxidative stress and inhibition of oxidases, as well as downregulation of the expression of key genes involved in mycotoxin production.…”

Section: Discussionmentioning

confidence: 99%

“…In another study with A. westerdijkiae, ochratoxin A (OTA) production was reduced by 35% by ferulic acid, while the fungal growth was unaffected [13]. Ahmed et al [14] recently reviewed naturally occurring phenolic compounds as promising bioagents to inhibit fungal growth and/or to limit mycotoxin yields, including practical application of pathogen fungi control, especially for Fusarium. The most abundant PAs in cereal grains are hydroxycinnamic derivatives such as caffeic, chlorogenic, ferulic, and p-coumaric acids [15].…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of Aspergillus Parasiticus Growth and Aflatoxins Production by Natural Essential Oils and Phenolic Acids

Lorán

Carramiñana

Juan

et al. 2022

Toxins

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Aflatoxins represent a significant risk to food safety, and strategies are being implemented to reduce their entry into the food chain. The aim of this study was to evaluate the in vitro effect of four essential oils (EOs) (lavandins Grosso and Abrial, Origanum virens, and Rosmarinus officinalis) and four natural phenolic acids (PAs) (caffeic, chlorogenic, ferulic, and p-coumaric) on the growth and aflatoxins (B1, B2, G1, and G2) production by Aspergillus parasiticus. Minimal inhibitory concentration (MIC) and minimal fungicide concentration (MFC) were determined by the broth macrodilution method. Additionally, the mycelia weight was determined at concentration levels lower than MIC. The antiaflatoxigenic activity was evaluated in the two concentrations of the EOs right before MIC and at concentrations below the MIC value for the PAs. To this end, in-house validated methodology based on high-performance liquid chromatography with post-column photochemical derivatization and fluorescence detection (HPLC-PHRED-FLD) was used. EOs of O. virens and lavandins (Grosso and Abrial) completely inhibited mold growth. In addition, a significant reduction in mycelial mass (p < 0.05) was observed for all EOs and PAs at different concentrations. In all cases except for lavandin Abrial, EO concentrations just before the MIC value strongly reduced (p < 0.05) aflatoxins synthesis. Aflatoxins production was completely inhibited by all PAs at a concentration of 20 mM; although at low concentrations, mycotoxin production was stimulated in some cases. The present study provides a scientific basis for further study of the inhibiting mechanisms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhibition of Aspergillus Parasiticus Growth and Aflatoxins Production by Natural Essential Oils and Phenolic Acids

Lorán

Carramiñana

Juan

et al. 2022

Toxins

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Section: Pps Mechanism Of Actions For Improving Afs Complicationsmentioning

confidence: 99%

“…As documented in the literature, PPs exhibited antifungal activity against various types fungal pathogens (407). Respectively, Ahmed and colleagues comprehensively reviewed the inhibitory profile of PPs in preventing AFs production (407). This study, however, focused on PPs mechanism of actions to inhibit AFs formation, and highlighted the associated food safety issues (407).…”

Section: Pps Mechanism Of Actions For Improving Afs Complicationsmentioning

confidence: 99%

May phytophenolics alleviate aflatoxins-induced health challenges? A holistic insight on current landscape and future prospects

2022

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The future GCC-connected environmental risk factors expedited the progression of nCDs. Indeed, the emergence of AFs is becoming a global food security concern. AFs are lethal carcinogenic mycotoxins, causing damage to the liver, kidney, and gastrointestinal organs. Long-term exposure to AFs leads to liver cancer. Almost a variety of food commodities, crops, spices, herbaceous materials, nuts, and processed foods can be contaminated with AFs. In this regard, the primary sections of this review aim to cover influencing factors in the occurrence of AFs, the role of AFs in progression of nCDs, links between GCC/nCDs and exposure to AFs, frequency of AFs-based academic investigations, and world distribution of AFs. Next, the current trends in the application of PPs to alleviate AFs toxicity are discussed. Nearly, more than 20,000 published records indexed in scientific databases have been screened to find recent trends on AFs and application of PPs in AFs therapy. Accordingly, shifts in world climate, improper infrastructures for production/storage of food commodities, inconsistency of global polices on AFs permissible concentration in food/feed, and lack of the public awareness are accounting for a considerable proportion of AFs damages. AFs exhibited their toxic effects by triggering the progression of inflammation and oxidative/nitrosative stress, in turn, leading to the onset of nCDs. PPs could decrease AFs-associated oxidative stress, genotoxic, mutagenic, and carcinogenic effects by improving cellular antioxidant balance, regulation of signaling pathways, alleviating inflammatory responses, and modification of gene expression profile in a dose/time-reliant fashion. The administration of PPs alone displayed lower biological properties compared to co-treatment of these metabolites with AFs. This issue might highlight the therapeutic application of PPs than their preventative content. Flavonoids such as quercetin and oxidized tea phenolics, curcumin and resveratrol were the most studied anti-AFs PPs. Our literature review clearly disclosed that considering PPs in antioxidant therapies to alleviate complications of AFs requires improvement in their bioavailability, pharmacokinetics, tissue clearance, and off-target mode of action. Due to the emergencies in the elimination of AFs in food/feedstuffs, further large-scale clinical assessment of PPs to decrease the consequences of AFs is highly required.

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“…Singh et al, 2017;Campos-Vega et al, 2010;Gao et al, 2017;Mecha et al, 2020). Ahmed et al (2022) recently presented the state-of-theart on the use of phenols as antimycotoxigenic agents. Their review summarizes several in vitro studies where phenolic plant extracts from fruits, cereals, microalgae, and others (e.g., mint) were used to reduce mycotoxin contents.…”

Section: Potential Effect Of Phenolic Compounds On Mycotoxin Producti...mentioning

confidence: 99%

Occurrence of mycotoxins in pulses

Acuña‐Gutiérrez

Jiménez

Müller

2022

Comp Rev Food Sci Food Safe

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Pulses, dry grains of the Fabaceae family used for food and feed, are particularly important agricultural products with increasing commercial and nutritional relevance. Similar to other plant commodities, pulses can be affected by fungi in the field and during postharvest. Some of these fungi produce mycotoxins, which can seriously threaten human and animal health by causing acute poisoning and chronic effects. In this review, information referring to the analysis and occurrence of these compounds in pulses is summarized. An overview of the aims pursued, and of the methodologies employed for mycotoxin analysis in the different reports is presented, followed by a comprehensive review of relevant articles on mycotoxins in pulses, categorized according to the geographical region, among other considerations. Moreover, special attention was given to the effect of climatic conditions on microorganism infestation and mycotoxin accumulation. Furthermore, the limited literature available was considered to look for possible correlations between the degree of fungal infection and the mycotoxin incidence in pulses. In addition, the potential effect of certain phenolic compounds on reducing fungi infestation and mycotoxin accumulation was reviewed with examples on beans. Emphasis was also given to a specific group of mycotoxins, the phomopsins, that mainly impact lupin. Finally, the negative consequences of mycotoxin accumulation on the physiology and development of contaminated seeds and seedlings are presented, focusing on the few reports available on pulses. Given the agricultural and nutritional potential that pulses offer for human well-being, their promotion should be accompanied by attention to food safety issues, and mycotoxins might be among the most serious threats.

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Naturally occurring phenolic compounds as promising antimycotoxin agents: Where are we now?

Cited by 20 publications

References 216 publications

Inhibition of Aspergillus Parasiticus Growth and Aflatoxins Production by Natural Essential Oils and Phenolic Acids

Inhibition of Aspergillus Parasiticus Growth and Aflatoxins Production by Natural Essential Oils and Phenolic Acids

May phytophenolics alleviate aflatoxins-induced health challenges? A holistic insight on current landscape and future prospects

Occurrence of mycotoxins in pulses

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