Naturally occurring organoiodines

Abstract

This review, with 290 references, presents the fascinating area of iodinated natural products over the past hundred years for the first time.

Four‐Component Relativistic DFT Calculations of 13C Chemical Shifts of Halogenated Natural Substances

“…Even more importantly,i tw ould allow for ab etter characterization of the large number of natural organohalogen compounds, which constitute an important portion of marine natural substances or pose environmental concerns. [18,19] Early attempts at accurately predicting the 13 CNMR shifts in o-bromochlorobenzene [20] and polyarsenicals [21] highlighted the need of including relativistic effects up to spin-orbit coupling and provided some quantitative assessment. More recently, the problem hasb een considered in ap urely empirical fashion, with acceptance that currently adopted model chemistries lead to large errors in the predicted shifts of carbon atoms directly bonded to halogen atomsa nd with correction by ac onstant offset accordingly.…”

The concept of photochemical enzyme models – State of the art

“…For example, the amino acid halogenation steps catalyzed by thyroid peroxidase (TPO, EC 1.11.1.8.) in the presence of hydrogen peroxide are important steps in the biosynthesis of thyroid hormones triiodoand tetraiodothyronine [233,234]. In the synthesis of steroid hormones (steroidogenesis) the type of reactions catalyzed by monooxygenases of the cytochrome P450 family (EC.1.14.14.1) plays an important role when bioactive steroids are generated from cholesterol [235].…”

Expeditious Syntheses to Pharmochemicals 1,3-Dihydroxyacetone, 1,3-Dichloro-, 1,3-Dibromo- and 1,3-Diiodoacetone from Glycerol 1,3-Dichlorohydrin Using Homogenous and Heterogenous Medium

“…[44][45][46][47][48][49][50][51][52][53][54][55][56][57] Interestingly, they have been isolated from marine algae of the genus Asparagopsis taxiformis, A. armata and Falkenbergia rufolanosa. 58,59 The 1,3-dichloroacetone is used in the synthesis of famotidine and citric acid and as substrate in crossed aldol condensation reactions. 56,57 The 1,3-diiodoacetone has been used as a microbicide and algaecide for the treatment of industrial water since is not lacrimogenic as the 1,3-dibromoacetone.…”