Naturally Occurring Multiple Perineuriomas in a Chicken (Gallus domesticus)

Abstract

Abstract.A 2-year-old, male Japanese native fowl (Gallus gallus domesticus) was presented with an inability to feed and torticollis. At a necropsy, there were cylindrical enlargements and yellow discoloration of multiple peripheral nerves, including nerves of the lumbosacral plexus, brachial plexus, and spinal ganglia. On histologic examination, these lesions consisted of diffuse proliferations of spindle cells with characteristic onion bulb-like structures around residual axons. The spindle cells were immunohistochemically positive for glucose transporter 1 (GLUT1) and negative for S-100 a/b proteins. On the basis of microscopic, histologic, and immunohistochemical findings, the tumors were diagnosed as multiple perineuriomas.

Spontaneous spinal plexiform perineurioma in a juvenile chicken (Gallus domesticus)

“…Immunohistochemistry findings contrast with those described in other reports, in which perineurial cells were immunohistochemically positive for GLUT1 and negative for S100 in humans 4 and chickens 8 with perineuriomas. Consistent with such reports 4,8 is the negative immunohistochemical detection of S100 in the neoplasm described herein, which rules out Schwann cells as its origin. However, a specific cause for the discrepancy in immunohistochemical detection of GLUT1 could not be determined.…”

Case report: Intraneural perineurioma in dogs: a case series and brief literature review

“…The World Health Organization (WHO) classification of tumors of the peripheral nerves includes Schwannoma, neurofibroma, perineurioma, and malignant peripheral nerve sheath tumors (1). Among these, perineurioma is rarely reported in the human literature and has limited cases documented in veterinary medicine (2)(3)(4)(5)(6)(7)(8).…”

Malignant Cutaneous Peripheral Nerve Sheath Tumour with Rhabdomyosarcomatous Differentiation (Triton Tumour) in a Domestic Cat

“…Benign neurofibromas, schwannomas and a few perineuriomas are known in animals, but detailed reports are few (Higgins et al, 2006;Ochi et al, 2008;Schoniger and Summers, 2009;Schoniger et al, 2011). PNSTs in animals occur most commonly in the dog and most of these are MPNSTs, arising within the brachial plexus, other spinal nerves or the trigeminal nerve (Summers et al, 1995).…”