Naturally occurring antioxidant nutrients reduce inflammatory response in mice

Новоселова, Е. Г.; Лунин, С. М.; Новоселова, Т. В.; Хренов, М. О.; Глушкова, О. В.; Avkhacheva, Nadezhda V.; Safronova, V. G.; Фесенко, Е. Е.

doi:10.1016/j.ejphar.2009.05.004

Cited by 51 publications

(27 citation statements)

References 33 publications

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“…No report in the literature describes a study examining the effects of CoQ10 on HSP production in response to exercise. Supplementation with antioxidants including ␤-carotene, ␣-tocopherol, and CoQ9 reportedly reduced LPS-stimulated HSP production by spleen lymphocytes from mice (Novoselova et al 2009). Future studies must examine the effects of CoQ10 on systemic inflammation mechanisms including TLR-4, cytokines, ROS, and HSP in response to exercise.…”

Section: Discussionmentioning

confidence: 97%

Coenzyme Q10 supplementation downregulates the increase of monocytes expressing toll-like receptor 4 in response to 6-day intensive training in kendo athletes

Shimizu

Kon

Tanimura

et al. 2015

Appl. Physiol. Nutr. Metab.

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This study examined changes in toll-like receptor 4 (TLR-4)-expressing monocytes and lymphocyte subpopulations in response to continuous intensive exercise training in athletes, as well as the effect of coenzyme Q10 (CoQ10) supplementation on these changes. Eighteen male elite kendo athletes in Japan were randomly assigned to a CoQ10-supplementation group (n = 9) or a placebo-supplementation group (n = 9) using a double-blind method. Subjects in the CoQ10 group took 300 mg CoQ10 per day for 20 days. Subjects in the placebo group took the same dosage of placebo. All subjects practiced kendo 5.5 h per day for 6 consecutive days during the study period. Blood samples were collected 2 weeks before training, on the first day (day 1), third day (day 3), and fifth day of training (day 5), and 1 week after the training period (post-training) to ascertain TLR-4(+)/CD14(+) monocyte and lymphocyte subpopulations (CD3(+), CD4(+), CD8(+), CD28(+)/CD4(+), CD28(+)/CD8(+), and CD56(+)/CD3(-) cells) using flow cytometry analysis. The group × time interaction for TLR-4(+)/CD14(+) cells did not reach significance (p = 0.08). Within the CoQ10 group, the absolute number of TLR-4(+)/CD14(+) cells was significantly higher only at day 5. The placebo group showed a significant increase in the absolute number of TLR-4(+)/CD14(+) cells at day 3, day 5, and post-training (p < 0.05). There was no significant group × time interaction for any lymphocyte subpopulation. CD3(+), CD8(+), and CD56(+)/CD3(-) cells were significantly reduced at day 3 in both groups (p < 0.05). In conclusion, CoQ10 supplementation might downregulate the increase of TLR-4-expressing monocytes in response to continuous strenuous exercise training in kendo athletes.

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Section: Discussionmentioning

confidence: 97%

Coenzyme Q10 supplementation downregulates the increase of monocytes expressing toll-like receptor 4 in response to 6-day intensive training in kendo athletes

Shimizu

Kon

Tanimura

et al. 2015

Appl. Physiol. Nutr. Metab.

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“…The intensive production of ROS associated with inflammation generally results in OS (Macdonald et al, 2003). Under conditions of high OS, the abilities of cells to eliminate ROS become exhausted, and dietary sources of antioxidants are requirered (Novoselova et al, 2009). We studied two important endogenous antioxidants -coenzyme Q 10 (CoQ) and carnosine (CARN) as supplementary therapy in AA with the aim to contribute to the alternatives for dietetary complementary healing of RA.…”

Section: Endogenous Antioxidantsmentioning

confidence: 99%

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Bauerová¹,

Poništ²,

Nosáľ³

et al. 2012

Rheumatoid Arthritis - Treatment

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“…가시오갈피를 이용하여 면역작용에 미치는 영향을 조사 한 연구결과에서 사이토카인 발현이 감소된 경우 (Han et al, 2014;Lin et al, 2007)와 반대로 증가된 경우 (Yoon et al, 2004;Schmolz et al, 2001) (Li et al, 2001;Novoselova et al, 2009 …”

Section: 양한 물질이 면역을 증가시키는 것으로 알려지고 있다(Abou-unclassified

Effect of Supplementation of Acanthopanax senticosus on Growth Performance, Blood Biochemical Profiles and Expression of Pro-Inflammatory Cytokines in Broiler Chicks

Jang

Moon²,

Sohn³

2015

Korean Journal of Poultry Science

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This study was performed to examine the effects of dietary Acanthopanax senticosus (AS) on growth performance, immune organ weights, blood biochemical parameters and the expression of pro-inflammatory cytokines in broiler chicks. A total of 120 4-day-old birds were given a basal diet (CON) or a basal diet supplemented with 0.5% (AS1) or 1.0% (AS2) AS powder until the birds were 35 days of age. There was no difference in body weight, total gain, feed intake or immune organ weights among the treatment groups. However, the feed conversion ratio in the AS2 group was lower (p<0.05) than that in the CON group. Serum biochemical components, including AST (aspartate aminotransferase), ALT (alanine aminotransferase), albumin and total protein, were not affected by the dietary treatments, whereas glucose and triglyceride levels increased (p<0.05) in the AS2 group compared with the CON group. The AS1 group exhibited decreased mRNA expression (p<0.05) of IFN-γ in white blood cells and iNOS in the liver compared with the CON group. The other pro-inflammatory cytokines were unaffected by dietary AS supplementation, although there was a trend towards decreased expression of these genes, including those encoding Il-1β, IL-6 and TNF-α. In conclusion, dietary supplementation with 0.5% AS decreased the expression of several pro-inflammatory cytokines without affecting growth performance, suggesting that this supplement might be applicable as an immunoregulatory feed additive in broiler chicks.

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Naturally occurring antioxidant nutrients reduce inflammatory response in mice

Cited by 51 publications

References 33 publications

Coenzyme Q10 supplementation downregulates the increase of monocytes expressing toll-like receptor 4 in response to 6-day intensive training in kendo athletes

Coenzyme Q10 supplementation downregulates the increase of monocytes expressing toll-like receptor 4 in response to 6-day intensive training in kendo athletes

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Effect of Supplementation of Acanthopanax senticosus on Growth Performance, Blood Biochemical Profiles and Expression of Pro-Inflammatory Cytokines in Broiler Chicks

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