Naturally occurring antinociceptive substances from plants

Calixto, João Β.; Beirith, Alessandra; Ferreira, Juliano; Santos, Adair Roberto Soares; Filho, Valdir Cechinel; Yunes, Rosendo A.

doi:10.1002/1099-1573(200009)14:6<401::aid-ptr762>3.3.co;2-8

Cited by 46 publications

(56 citation statements)

References 112 publications

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“…Hesperidin showed marked antinociception in mice against the nociception caused by i.p. injection of acetic acid (Calixto et al, 2000).…”

Section: Review Of Known Biological Effects Of the Plants And Their Cmentioning

confidence: 99%

“…Caffeine alone is used for respiratory depression in neonates and to treat postprandial hypotension. The analgesic adjuvant properties of caffeine in combination with aspirin-like drugs in treating pain is attributed to the blockade of peripheral and central adenosine receptors involved in the regulation of pain transmission (Calixto et al, 2000).…”

Section: Review Of Known Biological Effects Of the Plants And Their Cmentioning

confidence: 99%

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Non-experimental validation of ethnoveterinary plants and indigenous knowledge used for backyard pigs and chickens in Trinidad and Tobago

Lans

Georges

Brown

2007

Trop Anim Health Prod

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This paper presents the findings of an exploratory study on ethnoveterinary medicines used for backyard pigs and backyard chickens in Trinidad and Tobago. Research data was collected from 1995 to September 2000. Six plants are used for backyard pigs. Crushed leaves of immortelle (Erythrina pallida, E. micropteryx) are used to remove dead piglets from the uterus. Leaf decoctions of bois canôt (Cecropia peltata) and bamboo (Bambusa vulgaris) are used for labour pains or leaves are fed as a postpartum cleanser. Boiled green papaya fruit (Carica papaya) is fed to pigs to induce milk let-down. The leaves and flowers of male papaya plants (Carica papaya) are fed to deworm pigs. Sour orange juice (Citrus aurantium) is given to pigs to produce lean meat, and coffee grounds are used for scours. Eyebright and plantain leaves (Plantago major) are used for eye injuries of backyard chickens. Worm grass (Chenopodium ambrosioides) and cotton bush (Gossypium species) are used as anthelmintics. Aloe gel (Aloe vera) is used for internal injuries and the yellow sap from the cut Aloe vera leaf or the juice of Citrus limonia is used to purge the birds. A literature review revealed few toxicity concerns and the potential usefulness of the plants.

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“…Hesperidin showed marked antinociception in mice against the nociception caused by i.p. injection of acetic acid (Calixto et al, 2000).…”

Section: Review Of Known Biological Effects Of the Plants And Their Cmentioning

confidence: 99%

Section: Review Of Known Biological Effects Of the Plants And Their Cmentioning

confidence: 99%

Non-experimental validation of ethnoveterinary plants and indigenous knowledge used for backyard pigs and chickens in Trinidad and Tobago

Lans

Georges

Brown

2007

Trop Anim Health Prod

View full text Add to dashboard Cite

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“…It is important to mention that several pre-clinical and clinical studies have demonstrated the analgesic potential of different types of flavonoids [34,52], and orientin, which is present in high amounts in the plant, might be used to obtain new and promising derivatives with an analgesic profile. The potent antinociceptive effect of orientin may explain, at least partially, the beneficial effects of foods, tea or juice which have this compound in their composition [53][54][55].…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive properties of conocarpan and orientin obtained from Piper solmsianum C. DC. var. solmsianum (Piperaceae)

et al. 2010

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The antinociceptive properties of some fractions and two pure compounds, conocarpan and orientin, obtained from P. solmsianum leaves were investigated in several models of pain in mice. The results indicated that this plant exhibits a promising antinociceptive profile, as it produces active principles which are several times more active than some reference drugs used for comparison. The main compound tested, orientin, caused potent and dose-dependent effects against acetic acid-induced writhing and capsaicin- and glutamate-induced nociception, being more effective against the first one, with an ID(50) value of 6.5 mg/kg (14.5 micromol/kg). Orientin was about 20-fold more potent than acetylsalicylic acid and 3.5-fold more active than indomethacin. The antinociceptive effects of this plant may be attributed, at least partially, to the presence of conocarpan and, in particular, to the flavonoid orientin.

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“…Since previous studies have shown that the flavonoids quercetin, quercitrin and hyperoside possess antinociceptive effects when tested individually [33][34][35], it is possible that the flavonoids present in the methanol extracts and butanol fraction of this species may be responsible, at least in part, for the antinociceptive effects reported here. On the other hand, since the benzophenone derivatives were detected as major compounds in the chloroform fraction and their subfractions, it can be hypothesized that these compounds may be also associated with the effects found in the present study.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive activity of Hypericum grandifolium Choisy in mice

2010

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The present study investigated the antinociceptive activity of different extracts prepared from the aerial parts of blossom of Hypericum grandifolium Choisy-a species native to the Macaronesian Region-using the acetic acid-induced writhing, formalin and tail flick test in mice. Oral administration of methanol extract (500 and 1,000 mg/kg p.o.), the aqueous, butanol and chloroform fractions (500 mg/kg p.o.) as well as subfractions F2 and F3 (45 mg/kg p.o.) from the chloroform fraction significantly inhibited acetic acid-induced writhing, with values ranging from 28 to 50% of inhibition. The methanol extract (1,000 mg/kg p.o.) and chloroform fraction (500 mg/kg p.o.) significantly reduced both phases of formalin-induced pain (with inhibition values ranging from 18 to 53%), whereas subfraction F2 (45 mg/kg p.o.) significantly inhibited the late phase (30%). In the tail flick assay, only the chloroform fraction (500 mg/kg p.o.) significantly prolonged the tail flick response. Different constituents, such as flavonoids and benzophenone derivatives, could account for the effects observed. Taking together, the results indicate that Hypericum grandifolium Choisy possesses both peripheral and central antinociceptive activities in mice, suggesting an interesting therapeutic potential for this species in pain diseases.

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Naturally occurring antinociceptive substances from plants

Cited by 46 publications

References 112 publications

Non-experimental validation of ethnoveterinary plants and indigenous knowledge used for backyard pigs and chickens in Trinidad and Tobago

Non-experimental validation of ethnoveterinary plants and indigenous knowledge used for backyard pigs and chickens in Trinidad and Tobago

Antinociceptive properties of conocarpan and orientin obtained from Piper solmsianum C. DC. var. solmsianum (Piperaceae)

Antinociceptive activity of Hypericum grandifolium Choisy in mice

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