Naturally Occurring Acid-Soluble Nucleotides

Mantidisflavin A: A Riboflavin Derivative Featuring a 6/6/6/5/5 Skeleton from the Egg Cases of the Insect Tenodera sinensis Saussure and Its Anti-Renal Fibrosis Activity

“…Naturally occurring riboflavin derivatives include the formation of novel phosphate derivatives at the primary alcohol on the side chain, like flavin mononucleotide and flavin adenine dinucleotide. 14,15 Yet, there have been no observations regarding the natural formation of new derivatives with internally constructed rings. The present study describes the isolation and structural 1) spectra show 17 carbon signals classified into two CH 3 , two CH 2 , four CH (two nitrogen-or oxygen-bearing and two olefinic), and nine C (two carbonyls, three nitrogen-or oxygen-bearing, and four olefinic).…”

“…This investigation resulted in the isolation of an unprecedented 6/6/6/5/5 skeleton, mantidisflavin A ( 1 ), originating from riboflavin (Figure ). Naturally occurring riboflavin derivatives include the formation of novel phosphate derivatives at the primary alcohol on the side chain, like flavin mononucleotide and flavin adenine dinucleotide. , Yet, there have been no observations regarding the natural formation of new derivatives with internally constructed rings. The present study describes the isolation and structural elucidation of a highly novel compound with new ring formations on a familiar precursor and also details the biogenetic pathway and renal fibrosis inhibitory activity.…”

PURINES, PYRIMIDINES & RELATED COMPOUNDS

“…( 7 ) If therefore they are extracted from a tissue preparation by washing with acid the process must be carried out at 0°C and the extract neutralized as soon as possible. They are not readily attacked by acids or alkalis and consequently can be extracted from tissue preparations by relatively drastic methods such as washing with hot dilute acids.…”