Naturally-derived electrospun wound dressings for target delivery of bio-active agents

Fahimirad, Shohreh; Ajalloueian, Fatemeh

doi:10.1016/j.ijpharm.2019.05.053

Cited by 134 publications

(78 citation statements)

References 198 publications

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“…Nowadays, electrospinning is regarded as a key technology for the production of biomimetic membranes for tissue engineering and particularly for the treatment of skin wounds [87]. Electrospun mats can be engineered to promote wound healing, while protecting the wound site against bacteria colonisation, releasing drugs at a controlled rate, facilitating the exchange of water and gases, and being mechanically flexible to adapt to the wound region.…”

Section: Peppermint Essential Oilmentioning

confidence: 99%

Electrospinning of Essential Oils

Mele

2020

Polymers

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The extensive and sometimes unregulated use of synthetic chemicals, such as drugs, preservatives, and pesticides, is posing big threats to global health, the environment, and food security. This has stimulated the research of new strategies to deal with bacterial infections in animals and humans and to eradicate pests. Plant extracts, particularly essential oils, have recently emerged as valid alternatives to synthetic drugs, due to their properties which include antibacterial, antifungal, anti-inflammatory, antioxidant, and insecticidal activity. This review discusses the current research on the use of electrospinning to encapsulate essential oils into polymeric nanofibres and achieve controlled release of these bioactive compounds, while protecting them from degradation. The works here analysed demonstrate that the electrospinning process is an effective strategy to preserve the properties of essential oils and create bioactive membranes for biomedical, pharmaceutical, and food packaging applications.

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Section: Peppermint Essential Oilmentioning

confidence: 99%

Electrospinning of Essential Oils

Mele

2020

Polymers

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“…In recent years, electrospun nano-bers have been widely used in the pharmaceutical eld. 11 A variety of drugs including antibiotics, 12 proteins, 13 DNA, RNA, growth factors 14 and anticancer drugs have been loaded into electrospun nanobers for disease treatment. [15][16][17] In recent years, many kinds of enzyme have also been successfully immobilized in bers by electrospinning.…”

Section: Introductionmentioning

confidence: 99%

Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

et al. 2019

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“…Electrospun nanofibers have demonstrated considerable potency to encapsulate and deliver biofactors and drugs promoting the tissue RG process . Various studies extensively reported that polymeric nanofibers can be applied as a biocompatible scaffold for biomedical purposes such as wound dressings . According to our previous report, Cur plus BFP‐MSCs were put on the electrospun scaffold as a novel construct for the application of RG medicine .…”

Section: Discussionmentioning

confidence: 99%

Wound healing improvement by curcumin‐loaded electrospun nanofibers and BFP‐MSCs as a bioactive dressing

Golchin

Hosseinzadeh

Jouybar

et al. 2020

Polymers for Advanced Techs

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Wound healing, one of the most complex processes of the body involving the cooperation of several important biomolecules and pathways, is one of the major therapeutic and economic issues in regenerative medicine. The present study aimed to introduce a novel electrospun curcumin (Cur)-incorporated chitosan/polyvinyl alcohol/carbopol/polycaprolactone nanofibrous composite for concurrent delivery of the buccal fat pad-derived mesenchymal stem cells (BFP-MSCs) and Cur to a fullthickness wound on the mouse model. Scaffolds were characterized structurally using scanning electron microscopy (SEM), fluorescence microscopy imaging and Fouriertransform infrared spectroscopy, and toxicity of the scaffolds was also evaluated after BFP-MSC seeding by SEM imaging and 3-(4,5 dimethyiazol-2-1)-2-5-diphenyl tetrazolium bromide (MTT) assay. Then, its influence on the wound-healing process was investigated as a wound dressing for a full-thickness skin defect in mouse model.Results demonstrated that the designed composite scaffolds have the capability for cell seeding and support their growth and proliferation. Macroscopic and histopathological characteristics were evaluated at the end of the 7 and 14 days after surgery, and their results showed that our designed scaffold groups accelerated the woundhealing process compared with the control group. Among those, scaffold/Cur, scaffold/Cur/BFP-MSC and scaffold/BFP-MSC groups demonstrated more wound repair efficacy. These results indicated that the combined grafts can be used to improve the wound-healing process, and therefore, the electrospun nanofibers presented in this study, Cur and BFP-MSC together, were demonstrated to have promising potential for wound-dressing applications. K E Y W O R D S chitosan/polyvinyl alcohol/carbopol/polycaprolactone, curcumin, electrospun nanofibers, mesenchymal stem cells, regenerative medicine, wound healing

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Naturally-derived electrospun wound dressings for target delivery of bio-active agents

Cited by 134 publications

References 198 publications

Electrospinning of Essential Oils

Electrospinning of Essential Oils

Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

Wound healing improvement by curcumin‐loaded electrospun nanofibers and BFP‐MSCs as a bioactive dressing

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