Naturally derived dual dynamic crosslinked multifunctional hydrogel for diabetic wound healing

Shi, Tong; Lu, Hanzhi; Zhu, Jian-Yong; Zhou, Xiaojun; He, Chuanglong; Li, Fulun; Yang, Guang

doi:10.1016/j.compositesb.2023.110687

“…7a, there were still obvious defects in the PBS groups, with large wound areas not covered by epithelial tissue and signi cant in ammatory response (marked with black arrows). Compared with those in PBS groups, the wounds in CG hydrogels group showed abundant mature granulation tissue and complete epithelial structure, indicating that chitin hydrogels can accelerate the epithelialization process by promoting the development of granulation tissue (An et al, 2023;Shi et al, 2023). It is remarkably, however, the wounds in CZG-2 hydrogels group were basically completely healed, and the corneum and basal layers (marked with green dotted line) were intact.…”

Section: Antibio Lm and Wound Healing Performances In Vivomentioning

confidence: 90%

“…Collagen is critical for promoting wound healing and dermal reconstruction (Shi et al, 2023;Gaspar-Pintiliescu et al, 2019;Linju and Rekha, 2023). As shown in Fig.…”

Section: Antibio Lm and Wound Healing Performances In Vivomentioning

confidence: 99%

ZnO-incorporated chitin hydrogels for infected wound therapy

Zhang,

Xu,

Wang

et al. 2024

Cellulose

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Chronic wounds caused by pathogenic bacterial infections have been a worldwide medical threat and challenge, ZnO is a promising antibacterial agent to promote infected wound healing. However, ZnO particles need to be with a wound dressing material to improve low-dose antibacterial e cacy while reducing cytotoxicity. The natural polysaccharide, chitin-based hydrogels can be applied as a preferential supporting matrix for the deposition of ZnO. In this study, we developed chitin/ZnO composite hydrogels (CZG hydrogels), which were applied for the bio lm-infected full-thickness wound treatment. The threedimensional hydrophilic network structure of chitin hydrogels provided a large number of absorption sites for Zn 2+ ions, and CZG hydrogels were prepared by in situ synthesis of ZnO. CZG hydrogels had potent broad-spectrum and long-lasting antibacterial activity, good bacteriostatic ability against high concentration of bacterial uids. The in vivo studies showed that CZG hydrogels have a signi cant effect of accelerating bio lm-infected wound healing. Collectively, this work con rmed that chitin hydrogels could be applied as a preferential natural supporting matrix for the deposition of inorganic metal and metal oxide nanoparticles, and provided alternative antibacterial dressing for treating microbial infections and promoting wound healing.hydrogels have multiple advantages such as biocompatibility, biodegradability, and three-dimensional hydrophilic polymer network structure similar to the macromolecular biological tissue, which are extensively used in biomedical application (Huang et al., 2021;Kang et al., 2022;Anitha et al., 2014). To improve its properties and broaden its applications, chitin hydrogel has been modi ed, such as with polyphenol or hydroxyapatite (Cao et al., 2023;Xing et al., 2021;Lin et al., 2021a). In our previous work, Mn 3 O 4 nanoparticles were formed in the network of chitin hydrogels via in situ mineralization process and encapsulated to fabricate novel chitin/Mn 3 O 4 composite hydrogels, with NIR-assisted outstanding photothermal antibacterial and antibio lm activities (Zhang et al., 2023). Thereby, chitin hydrogels can be applied as a preferential natural supporting matrix for the deposition of ZnO.Hence, in this work, we attempted to fabricate chitin/ZnO composite hydrogels by in situ conversion of Zn 2+ to ZnO throughout chitin hydrogel networks. It is anticipated that chitin/ZnO composite hydrogels combine their unique properties. Therefore, the broad-spectrum antibacterial activity and biocompatibility of chitin/ZnO composite hydrogels were systematically investigated. Furthermore, the wound healing performance of the chitin/ZnO composite hydrogels was evaluated in a mouse full-thickness S. aureus bio lm-infected wound model. Materials and methods MaterialsThe raw chitin from shrimp shell was purchased from Zhejiang Golden-Shell Biochemical Co. Ltd., China, and puri ed according to the reported procedure (Ding et al., 2012). NH 3 •H 2 O, Zn(NO 3 ) 2 •6H 2 O, and other reagents were of...

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“…In the processes of tissue repair, macrophages play an important regulatory function. 68 Generally, M2 macrophages are in charge of positively regulating antiinflammation whereas M1 macrophages induce an inflammatory response. 69 Deep soft tissue injuries are frequently associated with the dysfunction of macrophages.…”

Section: Antibacterial Property Of the Hydrogel Adjuvantmentioning

confidence: 99%

Novel Hydrogel Adjuvant of Chinese Medicine External Preparations for Accelerated Healing of Deep Soft Tissue Injuries

Wang,

Xia,

Yu

et al. 2024

ACS Biomater. Sci. Eng.

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Traditional Chinese medicine external prescriptions have displayed excellent clinical effects for treating deep soft tissue injuries. However, the effects cannot be fully utilized due to the limitations of their dosage forms and usage methods. It is still a challenge to develop a satisfactory adjuvant of traditional Chinese medicine external prescriptions. Herein, a hydrogel adjuvant was prepared based on gallic acid coupled ε-poly-L-lysine and partially oxidized hyaluronic acid. The resulting adjuvant shows great physicochemical properties, low hemolysis rate (still much less than 5% at 5 mg/mL), excellent antibacterial ability (about 95% at 2 mg/mL), strong antioxidant ability (1.687 ± 0.085 mmol FeSO 4 /(g hydrogel) at 1 mg/mL), as well as outstanding biocompatibility. A clinically used Chinese medicine external preparation was selected as an example to investigate the effectiveness of the adjuvant in treating deep soft tissue injuries. The results show that the prescription can be evenly dispersed in the adjuvant. Moreover, the introduction of the prescription has not significantly changed these advanced properties of the adjuvant. Importantly, the hydrogel adjuvant significantly improves the effectiveness of the prescription in treating deep soft tissue injuries. This work offers an alternative approach to the development of a new-type adjuvant of Chinese medicine external preparations and also provides a new strategy for the combination of traditional Chinese medicine and hydrogel to treat clinical diseases.

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“…Collagen is critical for promoting wound healing and dermal reconstruction (Shi et al, 2023;Gaspar-Pintiliescu et al, 2019;Linju and Rekha, 2023). As shown in Fig.…”

Section: Antibio Lm and Wound Healing Performances In Vivomentioning

confidence: 99%

ZnO-incorporated chitin hydrogels for infected wound therapy

Zhang,

Xu,

Wang

et al. 2023

Preprint

0

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Chronic wounds caused by pathogenic bacterial infections have been a worldwide medical threat and challenge, ZnO is a promising antibacterial agent to promote infected wound healing. However, ZnO particles need to be with a wound dressing material to improve low-dose antibacterial efficacy while reducing cytotoxicity. The natural polysaccharide, chitin-based hydrogels can be applied as a preferential supporting matrix for the deposition of ZnO. In this study, we developed chitin/ZnO composite hydrogels (CZG hydrogels), which were applied for the biofilm-infected full-thickness wound treatment. The three-dimensional hydrophilic network structure of chitin hydrogels provided a large number of absorption sites for Zn2+ ions, and CZG hydrogels were prepared by in situ synthesis of ZnO. CZG hydrogels had potent broad-spectrum and long-lasting antibacterial activity, good bacteriostatic ability against high concentration of bacterial fluids. The in vivo studies showed that CZG hydrogels have a significant effect of accelerating biofilm-infected wound healing. Collectively, this work confirmed that chitin hydrogels could be applied as a preferential natural supporting matrix for the deposition of inorganic metal and metal oxide nanoparticles, and provided alternative antibacterial dressing for treating microbial infections and promoting wound healing.

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Naturally derived dual dynamic crosslinked multifunctional hydrogel for diabetic wound healing

Cited by 23 publications

References 41 publications

ZnO-incorporated chitin hydrogels for infected wound therapy

ZnO-incorporated chitin hydrogels for infected wound therapy

Novel Hydrogel Adjuvant of Chinese Medicine External Preparations for Accelerated Healing of Deep Soft Tissue Injuries

ZnO-incorporated chitin hydrogels for infected wound therapy

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