Naturally-Derived Biomaterials for Tissue Engineering Applications

Brovold, Matthew; Almeida, Joana; Plá-Palacín, Iris; Sainz‐Arnal, Pilar; Sánchez-Romero, Natalia; Rivas, Jesus J; Almeida, Helen; Dachary, Pablo Royo; Serrano-Aulló, Trinidad; Söker, Shay; Baptista, Pedro M.

doi:10.1007/978-981-13-0947-2_23

Cited by 84 publications

(48 citation statements)

References 257 publications

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“…Biomaterials are widely used to support and replace partially or completely tissues and organs to improve, augment, or restore biological functions (Brovold et al, ). However, implantation of biomaterials is followed by blood–material interaction, which leads to protein adsorption that can initiate an inflammatory cascade comprising injury, followed by acute and chronic inflammation, formation of granulation tissue, foreign body response, and eventually fibrous encapsulation.…”

Section: Introductionmentioning

confidence: 99%

Study on the potential mechanism of anti‐inflammatory activity of covalently immobilized hyaluronan and heparin

Al-Khoury

Hautmann

Erdmann

et al. 2020

J Biomedical Materials Res

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Inflammation and subsequent fibrotic encapsulation that occur after implantation of biomaterials are issues that fostered efforts in designing novel biocompatible materials to modulate the immune response. In this study, glycosaminoglycans (GAG) like hyaluronic acid (HA) and heparin (Hep) that possess anti‐inflammatory activity were covalently bound to NH2‐modified surfaces using EDC/NHS cross‐linking chemistry. Immobilization and physical surface properties were characterized by atomic forces microscopy, water contact angle studies and streaming potential measurements demonstrating the presence of GAG on the surfaces that became more hydrophilic and negatively charged compared to NH2‐modified. THP‐1 derived macrophages were used here to study the mechanism of action of GAG to affect the inflammatory responses illuminated by studying macrophage adhesion, the formation of multinucleated giant cells (MNGCs) and IL‐1β release that were reduced on GAG‐modified surfaces. Detailed investigation of the signal transduction processes related to macrophage activation was performed by immunofluorescence staining of NF‐κB (p65 subunit) together with immunoblotting. We studied also association and translocation of FITC‐labeled GAG. The results show a significant decrease in NF‐κB level as well as the ability of macrophages to associate with and take up HA and Hep. These results illustrate that the anti‐inflammatory activity of GAG is not only related to making surfaces more hydrophilic, but also their active involvement in signal transduction processes related to inflammatory reactions, which may pave the way to design new anti‐inflammatory surface coatings for implantable biomedical devices.

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Section: Introductionmentioning

confidence: 99%

Study on the potential mechanism of anti‐inflammatory activity of covalently immobilized hyaluronan and heparin

Al-Khoury

Hautmann

Erdmann

et al. 2020

J Biomedical Materials Res

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“…Silks are protein polymers that are spun into fibers by Lepidoptera larvae , including silkworms, scorpions, spiders, flies, and mites [77]. Silk protein is a suitable material for nanotechnology, thanks to the high biocompatibility and biodegradability, mechanical stability, self-restructuring and easy control [78]. The silk biopolymer finds valuable uses in tissue regeneration as a matrix of wound healing and as a treatment for burn victims; these peptides are also used in cosmetics [78].…”

Section: Biomaterialsmentioning

confidence: 99%

“…Silk protein is a suitable material for nanotechnology, thanks to the high biocompatibility and biodegradability, mechanical stability, self-restructuring and easy control [78]. The silk biopolymer finds valuable uses in tissue regeneration as a matrix of wound healing and as a treatment for burn victims; these peptides are also used in cosmetics [78]. Interestingly, it has been demonstrated that silk helps more intensive chondrogenesis than collagen used as a scaffold material for cartilage engineering [79].…”

Section: Biomaterialsmentioning

confidence: 99%

The Role of Stiffness in Cell Reprogramming: A Potential Role for Biomaterials in Inducing Tissue Regeneration

d’Angelo

Benedetti

Tupone

et al. 2019

Cells

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The mechanotransduction is the process by which cells sense mechanical stimuli such as elasticity, viscosity, and nanotopography of extracellular matrix and translate them into biochemical signals. The mechanotransduction regulates several aspects of the cell behavior, including migration, proliferation, and differentiation in a time-dependent manner. Several reports have indicated that cell behavior and fate are not transmitted by a single signal, but rather by an intricate network of many signals operating on different length and timescales that determine cell fate. Since cell biology and biomaterial technology are fundamentals in cell-based regenerative therapies, comprehending the interaction between cells and biomaterials may allow the design of new biomaterials for clinical therapeutic applications in tissue regeneration. In this work, we present the most relevant mechanism by which the biomechanical properties of extracellular matrix (ECM) influence cell reprogramming, with particular attention on the new technologies and materials engineering, in which are taken into account not only the biochemical and biophysical signals patterns but also the factor time.

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“…However, some of their features may hamper their use in tissue engineering applications, especially bladder tissue engineering. Naturally derived scaffolds cannot be tailored conveniently to the desired features for different applications in diverse contexts of tissue engineering ( Brovold et al, 2018 ). Different preparation and sterilization methods, age, and species of the donor animals in the processing and production of natural scaffolds significantly affect the physical and biochemical properties of these scaffolds, resulting in considerable batch-to-batch dissimilarity.…”

Section: Bladder Tissue Engineeringmentioning

confidence: 99%

Electrospinning: Application and Prospects for Urologic Tissue Engineering

Zamani

Shakhssalim

Ramakrishna

et al. 2020

Front. Bioeng. Biotechnol.

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Functional disorders and injuries of urinary bladder, urethra, and ureter may necessitate the application of urologic reconstructive surgeries to recover normal urine passage, prevent progressive damages of these organs and upstream structures, and improve the quality of life of patients. Reconstructive surgeries are generally very invasive procedures that utilize autologous tissues. In addition to imperfect functional outcomes, these procedures are associated with significant complications owing to long-term contact of urine with unspecific tissues, donor site morbidity, and lack of sufficient tissue for vast reconstructions. Thanks to the extensive advancements in tissue engineering strategies, reconstruction of the diseased urologic organs through tissue engineering have provided promising vistas during the last two decades. Several biomaterials and fabrication methods have been utilized for reconstruction of the urinary tract in animal models and human subjects; however, limited success has been reported, which inspires the application of new methods and biomaterials. Electrospinning is the primary method for the production of nanofibers from a broad array of natural and synthetic biomaterials. The biomimetic structure of electrospun scaffolds provides an ECM-like matrix that can modulate cells' function. In addition, electrospinning is a versatile technique for the incorporation of drugs, biomolecules, and living cells into the constructed scaffolds. This method can also be integrated with other fabrication procedures to achieve hybrid smart constructs with improved performance. Herein, we reviewed the application and outcomes of electrospun scaffolds in tissue engineering of bladder, urethra, and ureter. First, we presented the current status of tissue engineering in each organ, then reviewed electrospun scaffolds from the simplest to the most intricate designs, and summarized the outcomes of preclinical (animal) studies in this area.

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Naturally-Derived Biomaterials for Tissue Engineering Applications

Cited by 84 publications

References 257 publications

Study on the potential mechanism of anti‐inflammatory activity of covalently immobilized hyaluronan and heparin

Study on the potential mechanism of anti‐inflammatory activity of covalently immobilized hyaluronan and heparin

The Role of Stiffness in Cell Reprogramming: A Potential Role for Biomaterials in Inducing Tissue Regeneration

Electrospinning: Application and Prospects for Urologic Tissue Engineering

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