Naturally and chemically acetylated polysaccharides: Structural characteristics, synthesis, activities, and applications in the delivery system: A review

Li, Hongyu; Wang, Ying‐Ping; Zhao, Ping; Guo, Lanping; Huang, Luqi; Li, Xia; Gao, Wenyuan

doi:10.1016/j.carbpol.2023.120746

Cited by 28 publications

(8 citation statements)

References 237 publications

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“…The acetylation is the most prevalent modification for plant polysaccharides, which regulates the physicochemical characteristics and protects plant cell walls from microbial hydrolytic enzymes [ 45 ]. In addition, natural and chemical acetylation exhibits an ability to modify the conformation of polysaccharide chains, resulting in an increased exposure of polar groups, which holds promise for enhancing immunomodulatory, antioxidant, and other related activities [ 46 ]. Coincidentally, D. officinale polysaccharides are abundantly present in natural acetylation [ 7 ], and the isolation process is significantly influenced by the concentration of ethanol, resulting in the distinct acetyl absorption peaks in DOP-1 and DOP-2 at around 1730 cm −1 of FTIR spectra.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ethanol Concentrations on Primary Structural and Bioactive Characteristics of Dendrobium officinale Polysaccharides

Yu,

Long,

Chi

et al. 2024

Nutrients

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Ethanol fractional precipitation can initially separate polysaccharides according to the structure, which exhibits strong correlation with the biological activities. This study aimed to investigate the impact of varying ethanol concentrations on the structural characteristics, and the antitumor and antioxidant activities of polysaccharides derived from Dendrobium officinale through ethanol fractional precipitation, as well as their internal relationships. The polysaccharides acquired by absolute alcohol additions at a final liquor-ethanol volume ratio of 1:1, 1:2, and 1:4 were named DOP-1, DOP-2, and DOP-4, and the supernatant was named DOP-S. The results of the structural analysis revealed that the increase in ethanol concentrations resulted in a reduction in the molecular weights and the acetylation degree of the polysaccharides, as well as a decrease in mannose content and an increase in glucose content. In vitro experiments demonstrated that DOP-S exhibited optimal antitumor and antioxidant activities. Animal experiments further confirmed that DOP-S suppressed the growth of solid tumors significantly, enhanced lymphocytes, mediated immune ability, and improved the activity of antioxidant enzymes. These findings would establish a theoretical foundation and provide technical support for further advances and applications of polysaccharides derived from D. officinale in the fields of food and medicine.

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Section: Discussionmentioning

confidence: 99%

Effects of Ethanol Concentrations on Primary Structural and Bioactive Characteristics of Dendrobium officinale Polysaccharides

Yu,

Long,

Chi

et al. 2024

Nutrients

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“…Microorganism origin of polysaccharides is dextran, and animal-derived polysaccharides are chitin, hyaluronic acid, and heparin. [51][52][53][54] Kenawy et al 55 used electrospinning to fabricate polyvinyl alcohol (10%) and dextran (5%), and obtained nano-bers are crosslinked with sodium ampicillin loaded citric acid (10%). Addition of citric acid enhanced mechanical and thermal stability of nanobers.…”

Section: Polysaccharidesmentioning

confidence: 99%

Surface modification strategies for improved hemocompatibility of polymeric materials: a comprehensive review

Bhattacharjee,

Savargaonkar,

Tahir

et al. 2024

RSC Adv.

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“…One key element influencing how hydrophobic polysaccharides are is the degree of substitution. Polysaccharides exhibit increased viscosity, thicker interfacial layer, improved hydrophobicity, and greater spatial site resistance when the degree of substitution is adequately increased . The denser conformation of the polysaccharide with increasing substitution and chain length and the increased degree of intramolecular hydrophobic interaction that contributed to the improvement in hydrophobicity was also the outcome of the formation of a strong intramolecular hydrophobic interaction force between the inner and outer extension chains of polysaccharides with a higher degree of substitution …”

Section: Effect Of Structural Modifications On the Physicochemical Pr...mentioning

confidence: 99%

Structurally Modified Polysaccharides: Physicochemical Properties, Biological Activities, Structure–Activity Relationship, and Applications

Chen,

Zhang,

Chen

2024

J. Agric. Food Chem.

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Polysaccharides are an important class of biomolecules derived from several sources. However, the inherent structure of polysaccharides prevents them from exhibiting favorable physicochemical properties, which restricts their development in agriculture, industry, food, and biomedicine. This paper systematically summarizes the changes in the primary and advanced structures of modified polysaccharides, and focuses on the effects of various modification methods on the hydrophobicity, rheological properties, emulsifying properties, antioxidant activity, hypoglycemic, and hypolipidemic activities of polysaccharides. Then there is a list the applications of modified polysaccharides in treating heavy metal pollutants, purifying water resources, improving beverage stability and bread quality, and precisely delivering the drug. When summarized and reviewed, the information above can shed further light on the relationship between polysaccharide structure and function. Determining the structure–activity relationship provides a scientific basis for the direction of molecular modifications of polysaccharides.

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Naturally and chemically acetylated polysaccharides: Structural characteristics, synthesis, activities, and applications in the delivery system: A review

Cited by 28 publications

References 237 publications

Effects of Ethanol Concentrations on Primary Structural and Bioactive Characteristics of Dendrobium officinale Polysaccharides

Effects of Ethanol Concentrations on Primary Structural and Bioactive Characteristics of Dendrobium officinale Polysaccharides

Surface modification strategies for improved hemocompatibility of polymeric materials: a comprehensive review

Structurally Modified Polysaccharides: Physicochemical Properties, Biological Activities, Structure–Activity Relationship, and Applications

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