Natural volatile oils derived from herbal medicines: A promising therapy way for treating depressive disorder

Zhang, Haoyang; Long, Yu; Yu, Shuang; Li, Dan; Yang, Ming; Guan, Yongmei; Zhang, Dingkun; Wan, Jinyan; Liu, Songyu; Ai, Shi; Li, Nan; Peng, Wei

doi:10.1016/j.phrs.2020.105376

Cited by 102 publications

(55 citation statements)

References 129 publications

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“…Natural medicines are precious resources that promises establishment of reliable candidate drugs with low toxicity and presents several effective monomers that possess specific pharmacological activities; these natural medicines include such as artemisinin (Tu, 2016), emodin (Zhang Q et al, 2020), and berberine (Wang et al, 2019). In addition, it has been reported that natural medicines are beneficial in controlling the manifestations of psychiatric disorders (Zhang Y et al, 2020). According to the pathogenesis and symptoms of patients with epilepsy, different ways of treatment have been considered.…”

Section: Resultsmentioning

confidence: 99%

Natural Medicines for the Treatment of Epilepsy: Bioactive Components, Pharmacology and Mechanism

et al. 2021

Front. Pharmacol.

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Epilepsy is a chronic disease that can cause temporary brain dysfunction as a result of sudden abnormal discharge of the brain neurons. The seizure mechanism of epilepsy is closely related to the neurotransmitter imbalance, synaptic recombination, and glial cell proliferation. In addition, epileptic seizures can lead to mitochondrial damage, oxidative stress, and the disorder of sugar degradation. Although the mechanism of epilepsy research has reached up to the genetic level, the presently available treatment and recovery records of epilepsy does not seem promising. Recently, natural medicines have attracted more researches owing to their low toxicity and side-effects as well as the excellent efficacy, especially in chronic diseases. In this study, the antiepileptic mechanism of the bioactive components of natural drugs was reviewed so as to provide a reference for the development of potential antiepileptic drugs. Based on the different treatment mechanisms of natural drugs considered in this review, it is possible to select drugs clinically. Improving the accuracy of medication and the cure rate is expected to compensate for the shortage of the conventional epilepsy treatment drugs.

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Section: Resultsmentioning

confidence: 99%

Natural Medicines for the Treatment of Epilepsy: Bioactive Components, Pharmacology and Mechanism

et al. 2021

Front. Pharmacol.

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“…Traditional Chinese medicines (TCMs) have been used in China to treat various diseases for thousands of years, and accumulating evidences have confirmed that TCMs are beneficial for the control and treatment of some intractable and chronic diseases such as mental disorders [22,23]. In addition, TCMs are suitable for the diseases which need longterm drug administration due to their relatively less toxicity compared to synthetic drugs [24].…”

Section: Discussionmentioning

confidence: 99%

Antiepileptic Effects of Cicadae Periostracum on Mice and Its Antiapoptotic Effects in H2O2-Stimulated PC12 Cells via Regulation of PI3K/Akt/Nrf2 Signaling Pathways

Zhang

Tao

et al. 2021

Oxidative Medicine and Cellular Longevity

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Cicadae Periostracum (CPM), a commonly used animal traditional Chinese medicine (TCM), possesses antifebrile, spasmolytic, antiasthmatic, and antiphlogistic effects. In our present paper, we aimed to systemically investigate the antiepileptic effects of CPM in epileptic mice and explore the related molecular mechanism. Pentylenetetrazole- (PTZ) and strychnine-induced convulsion mice were established, and the results showed CPM could prolong the latency of convulsion and death and improve the neuronal damage in the hippocampus of PTZ-induced mice. Furthermore, the H2O2-treated PC12 cells were prepared to explore the possible mechanisms for the antiepileptic effects of CPM. CCK-8 results showed that CPM significantly improved the cell viability of H2O2-treated PC12 cells. Results of the acridine orange- (AO-) ethidium bromide (EB) staining, cell mitochondrial membrane potential (MOMP) analysis, and flow cytometry analysis showed that CPM significantly suppressed the H2O2-induced apoptosis in PC12 cells. In addition, CPM also downregulated the proapoptosis proteins, including Bax, cleaved- (C-) caspase-3, and C-caspase-9, and upregulated Bcl-2. Furthermore, CPM reduced the reactive oxygen species (ROS) levels via increasing antioxidative enzyme activities, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). Importantly, CPM could increase the phosphorylation of phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt) in H2O2-induced PC12 cells and can promote the nuclear transfer of the nuclear factor E2-related factor 2 (Nrf2) and increase the expression of heme oxygenase-1 (HO-1) in the cytoplasm. In conclusion, our present study suggested CPM possessed antiepileptic effects through antiapoptosis of neuron cells via regulation of the PI3K/Akt/Nrf2 signaling pathway.

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“…Herbal medicines have been used in the treatment of liver diseases for a long time all over the world, especially in developing countries. 29 This study carried mainly on HAV extracted from children aged from 6 to 10 years old fecal samples. In Egypt HAV is wide spread among children as mentioned.…”

Section: Discussionmentioning

confidence: 99%

“…Those species characterized by the high contents of Essential Oils (EOs), which have a high value in medicinal properties. 29 Meanwhile, these species have been reported as antiviral plants due to their high contents in the Eos and other constituents, which give them potential inhibition against viral replication. 30 Family Lamiaceae is the most effective family in the treatment of HAV; species belonging to this family characterized by the presence of volatile oils, and these oils are used in the treatment of many diseases since a long time ago and till now, 31 found that the volatile oils in Eucalyptus species can be used as antibacterial, antioxidant, and antiproliferative activities.…”

Section: Discussionmentioning

confidence: 99%

Effect of some wild egyptian medicinal plants on HAV

Taia

Zayed

2021

Asian J Med Sci

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Background: Folk Egyptian medicine considered from the most important source of the use of wild plants in medication. Wild plants are considered a perfect source of natural compounds that have been used as antimicrobial andante virus activities. Aims and Objective: The aim of the current study was to investigate the effect of the commonly used wild plants in the treatment of jaundice and they effect on HAV. This article provides much-needed insight into the effect of wild plants on the hepatitis A virus to shed more light on the important subject, which is unfortunately poorly investigated. Materials and Methods: In this investigation, the aqueous plant extracts of twenty-five wild Egyptian species, 16 perennials, and 9 annuals; three concentrations, 1%, 3% & 5%; were tested for HAV replication by using PA and PCR techniques. Questionnaires and interviews with Bedouins have been carried to know the most used species in the treatment of jaundice, and the usage values were calculated. Those species were collected from their habitats, rare ones purchased and reviewed their identifications and used in this work. Fecal and blood samples were taken from 9-10Y old patients, 35 girls and 25 boys. Results: The PA test revealed that 16 species out of twenty-five gave positive results, while the rest of the species gave negative results on Vero cells. Twelve of the sixteen species were perennial species, and the rest are annuals. The Plaque assay results showed that the most effective aqueous extract species, with the three concentrations, on HAV activity were those of Salvia verbennaca, Mentha microphylla, Ocimum basilicum, Cassia senna, Solenostemma argel, and Thymus capitatus, respectively. PCR test has been carried for the first three species and gave very faint nucleic acid tapes, which means that the plant extract of these species, the three concentrations, minimize the virus activity by a way or another. Samples from the patients tested for the antibodies for IgM and IgG using the ELISA test. Within both the females (58%) and males (42%), 6% have positive antibodies for IgM, while 36% in females and 34% in males’ have positive antibodies for IgG and 8% females and 10% males have both antibodies (IgM & IgG). Conclusion: Wild plants, especially those with essential oils can tolerate the Hepatitis A virus (HAV) activity and reduce its symptoms.

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Natural volatile oils derived from herbal medicines: A promising therapy way for treating depressive disorder

Cited by 102 publications

References 129 publications

Natural Medicines for the Treatment of Epilepsy: Bioactive Components, Pharmacology and Mechanism

Natural Medicines for the Treatment of Epilepsy: Bioactive Components, Pharmacology and Mechanism

Antiepileptic Effects of Cicadae Periostracum on Mice and Its Antiapoptotic Effects in H2O2-Stimulated PC12 Cells via Regulation of PI3K/Akt/Nrf2 Signaling Pathways

Effect of some wild egyptian medicinal plants on HAV

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