Natural ventilation, low CO₂ and air filtration are associated with reduced indoor air respiratory pathogens

Abstract

Currently, the real-life impact of indoor climate, human behavior, ventilation and air filtration on respiratory pathogen detection and concentration are poorly understood. This hinders the interpretability of bioaerosol quantification in indoor air to surveil respiratory pathogens and transmission risk. We tested 341 indoor air samples from 21 community settings for 29 respiratory pathogens using qPCR. On average, 3.9 pathogens were positive per sample and 85.3% of samples tested positive for at least one. The number of detected pathogens and their respective concentrations varied significantly by pathogen, month, and age group in generalized linear (mixed) models and generalized estimating equations. High CO2 and low natural ventilation were independent risk factors for detection. CO2 concentration and air filtration were independently associated with their concentration. Occupancy, sampling time, mask wearing, vocalization, temperature, humidity and mechanical ventilation were not significant. Our results support the importance of ventilation and air filtration to reduce transmission.

Comparative Analysis of Indoor Air Quality and Thermal Comfort Standards in School Buildings across New Zealand with Other OECD Countries

“…Ventilation is crucial for designing and operating schools. It involves naturally or mechanically replacing contaminated air with clean air [56]. Ventilation rates are measured in litres per second per person or per square meter.…”