Natural transovarial transmission of dengue virus 4 in Aedes aegypti from Cuiabá, State of Mato Grosso, Brazil

Cruz, Lucinéia Claudia de Toni Aquino da; Serra, Otacília Pereira; Santos, Fábio Alexandre Leal dos; Ribeiro, Ana Lúcia Maria; Slhessarenko, Renata Dezengrini; Santos, Marina Atanaka dos

doi:10.1590/0037-8682-0264-2014

Cited by 32 publications

(21 citation statements)

References 41 publications

(35 reference statements)

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“…vertical transmission) in arthropods or by horizontal transmission via infected vertebrates. As horizontal transmission is dependent on the density of susceptible hosts and their intervals of patent infection, the transovarial and/or transstadial pathways may be more reliable routes to transmit intracellular parasites4041. Although transovarial and/or transstadial transmission has been documented in members of the Rickettsiaceae 15174243, this process is not thought to occur to a significant degree in those Anaplasma and Ehrlichia bacteria documented to date, which may in part be due to lack of the aldolase/adducing domain protein44.…”

Section: Discussionmentioning

confidence: 99%

Extensive genetic diversity of Rickettsiales bacteria in multiple mosquito species

Guo

Tian

Lin³

et al. 2016

Sci Rep

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Rickettsiales are important zoonotic pathogens, causing severe disease in humans globally. Although mosquitoes are an important vector for diverse pathogens, with the exception of members of the genus Wolbachia little is known about their role in the transmission of Rickettsiales. Herein, Rickettsiales were identified by PCR in five species of mosquitoes (Anopheles sinensis, Armigeres subalbatus, Aedes albopictus, Culex quinquefasciatus and Cu. tritaeniorhynchus) collected from three Chinese provinces during 2014–2015. Subsequent phylogenetic analyses of the rrs, groEL and gltA genes revealed the presence of Anaplasma, Ehrlichia, Candidatus Neoehrlichia, and Rickettsia bacteria in mosquitoes, comprising nine documented and five tentative species bacteria, as well as three symbionts/endosybionts. In addition, bacteria were identified in mosquito eggs, larvae, and pupae sampled from aquatic environments. Hence, these data suggest that Rickettsiales circulate widely in mosquitoes in nature. Also of note was that Ehrlichia and Rickettsia bacteria were detected in each life stage of laboratory cultured mosquitoes, suggesting that Rickettsiales may be maintained in mosquitoes through both transstadial and transovarial transmission. In sum, these data indicate that mosquitoes may have played an important role in the transmission and evolution of Rickettsiales in nature.

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Section: Discussionmentioning

confidence: 99%

Extensive genetic diversity of Rickettsiales bacteria in multiple mosquito species

Guo

Tian

Lin³

et al. 2016

Sci Rep

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“…aegypti larvae, where DENV IV was identified. Following genetic sequencing analysis of DENV, the authors showed similarity to the DENV IV genotype II strain from Manaus [42]. This is an important result because it demonstrates the origin and geographical distribution of the strains that circulate in the country.…”

Section: Discussionmentioning

confidence: 99%

Transovarial transmission of DENV in Aedes aegypti in the Amazon basin: a local model of xenomonitoring

et al. 2017

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BackgroundTransovarial transmission of dengue virus in Aedes spp. mosquitoes is considered an important mechanism for the maintenance of the virus in nature and may be implicated in the occurrence of outbreaks and epidemics of the disease. However, there are few studies involving transovarial transmission and viral vector monitoring as a surveillance tool and control strategy. The present study evaluated transovarial transmission of dengue virus in Aedes aegypti populations as a xenomonitoring strategy in municipalities of the Amazonas state.Results Aedes sp. eggs (13.164) were collected, with 30% viability of third- and fourth-instar larvae. Transovarial transmission of DENV was detected in all municipalities. The transovarial infection rate (TOR) in the municipalities was 46% of the DENV positive samples. The minimum infection rate (MIR) was 17.7 in the state, varying from 11.4 to 24.1 per 1,000 larvae tested in the respective municipalities. Four DENV serotypes were identified, with DENV I and IV being present in all municipalities investigated. The number of reported dengue fever cases varied during this period.ConclusionsOur results suggest that transovarial transmission may be an important mechanism for the maintenance and spreading of the disease in Amazonas municipalities. Using qRT-PCR, it was possible to identify the four DENV serotypes in larval samples. The methodology used in the present study proved suitable as a DENV xenomonitoring model in immature mosquitoes, contributing to the development of systems for early detection of viral circulation and predictive models for the occurrence of outbreaks and epidemics of this disease.Trial registration CAAE34025414200005015.

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“…Cecílio et al [175] observed four positive pools, out of 54 tested, among Aedes mosquitoes collected in two regions of Brazil over the course of 17 months, through the installation of ovitraps in public schools. Cruz et al [155] detected eight positive pools, out of 50 Ae. aegypti pools, collected in Mato Grosso, Brazil.…”

Section: Resultsmentioning

confidence: 99%

Arbovirus Vectors of Epidemiological Concern in the Americas: A Scoping Review of Entomological Studies on Zika, Dengue and Chikungunya Virus Vectors

Jones

Kulkarni

Davidson

et al. 2019

Preprint

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27 Background 28 Three arthorpod-borne viruses (arboviruses) causing human disease have been the focus 29 of a large number of studies in the Americas since 2013 due to their global spread and 30 epidemiological impacts: Zika, dengue, and chikungunya viruses. A large proportion of 31 infections by these viruses are asymptomatic. However, all three viruses are associated with 32 moderate to severe health consequences in a small proportion of cases. Two mosquito species, 33 Aedes aegypti and Aedes albopictus, are among the world's most prominent arboviral vectors, 34 and are known primary vectors for all three viruses in the Americas. 35 Objectives 2 36 This review summarizes the state of the entomological literature surrounding the biology 37 and ecology of vectors of Zika, dengue and chikungunya viruses and factors affecting virus 38 transmission. The rationale of the review was to elucidate consensus and discord between 39 studies, and guide future research based on identified knowledge gaps. 40 Results 41 A total of 196 studies were included in the scoping review after initial screening and 42 subsequent exclusion of out-of-scope studies, secondary data publications, duplicate records, and 43 studies unavailable in English language. 44 Key findings 45 Temperature and humidity have the strongest impact on mosquito distribution and 46 dynamics, development of immatures and arborviral infection rates. Low socioeconomic status 47 and related factors, including poor infrastructure, inconsistent access to water, and high 48 household resident density, have been consistently associated with arbovirus vector occurrence. 49 Effects of interspecific competition on arboviral vector species is currently poorly understood. 50 Vector competence for Zika virus is well established for Ae. aegypti and Ae. albopictus. 51 Information on Zika virus vector transmission dynamics is sparse in contrast to the wealth of 52 research available for dengue and chikungunya viruses. 53 Conclusions 54Based on the internationally recognized urgency of Zika virus infection as a public health 55 concern, further research on arbovirus vectors and transmission dynamics is of pressing need. 56 57

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Natural transovarial transmission of dengue virus 4 in Aedes aegypti from Cuiabá, State of Mato Grosso, Brazil

Cited by 32 publications

References 41 publications

Extensive genetic diversity of Rickettsiales bacteria in multiple mosquito species

Extensive genetic diversity of Rickettsiales bacteria in multiple mosquito species

Transovarial transmission of DENV in Aedes aegypti in the Amazon basin: a local model of xenomonitoring

Arbovirus Vectors of Epidemiological Concern in the Americas: A Scoping Review of Entomological Studies on Zika, Dengue and Chikungunya Virus Vectors

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