Natural Transmission of Immunity against Trypanosoma lewisi from Mother Rats to Their Offspring

Protection against Experimental Necrotizing Enterocolitis by Maternal Milk. I. Role of Milk Leukocytes

“…Ncit h e r of t h c s e h y p o t h e s e s h a s been p r o v e n . P r e v i o u s ( 7 ) and s u b s e q u e n t s t u d i e s i n d i c a t e t h a t t h e disease can c l c v e l o p w i t h o u t i n t e n t i o n a l c o l o n i z a t i o n h u t is a l w a y s accompanied b y gramn e g a t i v e c n t c r i c o v e r g r o \ v t h in t h e i n t e s t i n e . S t u d i e s a r e u n d e rw a y i n g c r n~f r e e r a t s t o d e t e r m i n e t h e r o l e o f b a c t e r i a in t h i s disease.…”

The route by which passive immunity is transmitted from mother to foetus in the rat

“…Transmission of passive immunity from mother to young in the rat occurs in significant amounts both before and after birth, though th a t after birth is the greater (Culbertson, 1938(Culbertson, , 1939a. Since the foetal rat has an inverted yolk-sac th at persists until parturition, as in the foetal rabbit, the problem of whether transfer occurs by the same route, th at is, by way of the uterine cavity and the yolk-sac, is of interest.…”

Computational determination of the structure of rat fc bound to the neonatal fc receptor

“…The neonatal Fc receptor (FcRn) mediates the transfer of immunoglobulin G (IgG) molecules from maternal milk to the bloodstream of newborn mammals (Culbertson, 1938), thus providing passive humoral immunity during the ®rst few weeks of life. In particular, FcRn binds IgG Fc under slightly acidic (pH 6.0 to 6.5) conditions, but not at neutral or higher pH (Rodewald, 1976;Rodewald & Kraehenbuhl, 1984;Simister & Mostov, 1989;.…”