Natural Sources and Pharmacological Properties of Pinosylvin

Abstract

Pinosylvin (3,5-dihydroxy-trans-stilbene), a natural pre-infectious stilbenoid toxin, is a terpenoid polyphenol compound principally found in the Vitaceae family in the heartwood of Pinus spp. (e.g., Pinus sylvestris) and in pine leaf (Pinus densiflora). It provides defense mechanisms against pathogens and insects for many plants. Stilbenoids are mostly found in berries and fruits but can also be found in other types of plants, such as mosses and ferns. This review outlined prior research on pinosylvin, including its sources, the technologies used for its extraction, purification, identification, and characterization, its biological and pharmacological properties, and its toxicity. The collected data on pinosylvin was managed using different scientific research databases such as PubMed, SciFinder, SpringerLink, ScienceDirect, Wiley Online, Google Scholar, Web of Science, and Scopus. In this study, the findings focused on pinosylvin to understand its pharmacological and biological activities as well as its chemical characterization to explore its potential therapeutic approaches for the development of novel drugs. This analysis demonstrated that pinosylvin has beneficial effects for various therapeutic purposes such as antifungal, antibacterial, anticancer, anti-inflammatory, antioxidant, neuroprotective, anti-allergic, and other biological functions. It has shown numerous and diverse actions through its ability to block, interfere, and/or stimulate the major cellular targets responsible for several disorders.

Production of Nematicidal Pinosylvin Stilbenes in Cell Suspension Cultures of Pinus koraiensis by Fungal Elicitation

“…Plant cell and tissue culture are useful techniques for the production of secondary metabolites under controlled in vitro environments. Pinosylvin stilbenes have various beneficial effects such as antifungal, antibacterial, anti-inflammatory, antioxidant, neuroprotective, and anticancer activities [ 27 ]. The production of pinosylvin stilbenes was first reported by Lange et al [ 22 ] using P. sylvestris cell suspension cultures.…”

Genome-Wide Identification and Expression Analysis of TPS Gene Family in Liriodendron chinense

“…For example, carotenoids participate in photosynthetic reactions as photosynthetic pigments [ 8 , 9 ]; gibberellins, abscisic acid, and cytokinins participate as regulators of plant growth and development [ 10 ]; phytosterols participate as influencing factors of membrane structure and function [ 11 , 12 ]; ubiquinone and plastoquinone side chains function as electron carriers; and polyphenols participate in protein glycosylation [ 13 ]. However, terpenoids in most plants exist in the form of secondary metabolites, which do not directly participate in plant growth and development, but have certain physiological functions, such as plant defense responses [ 14 ], pharmacological compounds [ 15 ], and fragrance volatilization [ 4 , 16 , 17 ]. Terpenoids of secondary metabolism act as signal transduction in the interactions between plants and the environment, and between plants and animals, as well as between plants [ 18 ].…”

Inhibition of Resveratrol Analogs on Human and Rat 3β-Hydroxysteroid Dehydrogenases: Structure–Activity Relationship and Docking Analysis

“…Oxyresveratrol (ORV, 5 ) is a RSV analog from Artocarpus heterophyllus, and it is believed to be derived from RSV, but no experimental evidence has yet been found. Pinosylvin (PS, 6 ) and dihydropinosylvin (DHP, 7 ) are RSV analogs found mainly in white pines, and DHP is the metabolite of PS by gut microbiota. , 4,4′-Dihydroxystilbene (DHS, 8 ) is a RSV analog found in Yucca periculosa . These RSV analogs and metabolites have many pharmacological activities, including antidiabetic, antitumor, antioxidative, and anti-inflammatory effects. ,, …”