Natural small molecule-induced polymer hydrogels with inherent antioxidative ability and conductivity for neurogenesis and functional recovery after spinal cord injury

Wang, Fang; Du, Jiaqiang; Hao, Qiao; Liu, Dong-Fan; Guo, Dong; Chen, Jinjin; Zhang, Yanfeng; Cheng, Yilong; He, Xijing

doi:10.1016/j.cej.2023.143071

Cited by 7 publications

(8 citation statements)

References 43 publications

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“…As LA has high electron density, strong electrophilicity, and strong ability to react with reactive oxygen species, it has good antioxidant property and is a natural free radical scavenger. 36 The disulfide bond in the dithiolane of LA has light response, mercaptan response, and thermal response. 37 The thiol group formed by the disulfide bond cleavage has been proved to be able to bond with tissues and cells.…”

Section: Resultsmentioning

confidence: 99%

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Pluronic F127-Lipoic Acid Adhesive Nanohydrogel Combining with Ce³⁺/Tannic Acid/Ulinastatin Nanoparticles for Promoting Wound Healing

Wang,

Fang,

Yalikun

et al. 2023

Biomacromolecules

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Developing strong anti-inflammatory wound dressings is of great significance for protecting inflammatory cutaneous wounds and promoting wound healing. The present study develops a nanocomposite Pluronic F127 (F127)-based hydrogel dressing with injectable, tissue adhesive, and anti-inflammatory performance. Briefly, Ce 3+ /tannic acid/ulinastatin nanoparticles (Ce 3+ /TA/ UTI NPs) are fabricated. Meanwhile, α-lipoic acid is bonded to the ends of F127 to prepare F127-lipoic acid (F127LA) and its nanomicelles. Due to the gradual viscosity change instead of mutation during phase transition, the mixed Ce 3+ /TA/UTI NPs and F127LA nanomicelles show well-performed injectability at 37 °C and can form a semisolid composite nanohydrogel that can tightly attach to the skin at 37 °C. Furthermore, ultraviolet (UV) irradiation without a photoinitiator transforms the semisolid hydrogel into a solid hydrogel with well-performed elasticity and toughness. The UV-cured composite nanohydrogel acts as a bioadhesive that can firmly adhere to tissues. Due to the limited swelling property, the hydrogel can firmly adhere to tissues in a wet environment, which can seal wounds and provide a reliable physical barrier for the wounds. Ce 3+ /TA/UTI NPs in the hydrogel exhibit lipopolysaccharide (LPS)-scavenging ability and reactive oxygen species (ROS)-scavenging ability and significantly reduce the expression of inflammatory factors in wounds at the early stage, accelerating LPS-induced wound healing.

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Section: Resultsmentioning

confidence: 99%

“…LA is a natural thiol compound. As LA has high electron density, strong electrophilicity, and strong ability to react with reactive oxygen species, it has good antioxidant property and is a natural free radical scavenger . The disulfide bond in the dithiolane of LA has light response, mercaptan response, and thermal response .…”

Section: Resultsmentioning

confidence: 99%

Pluronic F127-Lipoic Acid Adhesive Nanohydrogel Combining with Ce³⁺/Tannic Acid/Ulinastatin Nanoparticles for Promoting Wound Healing

Wang,

Fang,

Yalikun

et al. 2023

Biomacromolecules

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“…In an analogous study based on ring-opening polymerization, Wang and coworkers synthesized a poly(lipoic acid-co-sodium lipoate) (PLL) hydrogel using a facile one-pot approach (Figure 7f). [54] Benefitting from the antioxidative properties of ALA, the PLL hydrogel was capable of efficiently scavenging DPPH• (the efficiency was 76% for PLL hydrogel with the concentration of 10 mg mL −1 ) (Figure 7g,h). In pursuit of enhanced functionality, LiCl was incorporated as a conductive filler to provide substantial electrical conductivity to the PLL hydrogel (the conductivity 0.54 S m −1 was achieved when the concentration of LiCl was 3 mm) (Figure 7i).…”

Section: Alpha-lipoic Acidmentioning

confidence: 98%

Antioxidant Hydrogels: Antioxidant Mechanisms, Design Strategies, and Applications in the Treatment of Oxidative Stress‐Related Diseases

Hu,

Ouyang,

Zhao

et al. 2024

Adv Healthcare Materials

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Oxidative stress is a biochemical process that disrupts the redox balance due to an excess of oxidized substances within the cell. Oxidative stress is closely associated with a multitude of diseases and health issues, including cancer, diabetes, cardiovascular diseases, neurodegenerative disorders, inflammatory conditions, and aging. Therefore, the developing of antioxidant treatment strategies has emerged as a pivotal area of medical research. Hydrogels have garnered considerable attention due to their exceptional biocompatibility, adjustable physicochemical properties, and capabilities for drug delivery. Numerous antioxidant hydrogels have been developed and proven effective in alleviating oxidative stress. In the pursuit of more effective treatments for oxidative stress‐related diseases, there is an urgent need for advanced strategies for the fabrication of multifunctional antioxidant hydrogels. Consequently, our focus will be on hydrogels that possess exceptional reactive oxygen species (ROS) and reactive nitrogen species (RNS) scavenging capabilities, and their role in oxidative stress therapy will be evaluated. Herein, the antioxidant mechanisms and the design strategies of antioxidant hydrogels and their applications in oxidative stress‐related diseases are discussed systematically in order to provide critical insights for further advancements in the field.This article is protected by copyright. All rights reserved

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“…Similarly, Wang et al fabricated antioxidative polymer hydrogels with thioether groups that possessed conductivity capabilities for SCI treatment. [43] A comprehensive evaluation was undertaken with the aim of enhancing the antioxidant capabilities of Polylysine (PLL) hydrogels. The evaluation involved four PLL hydrogel variations that were assessed using 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assays.…”

Section: Organic Ros-core Biomaterials For Sci Treatmentmentioning

confidence: 99%

“…Similarly, Wang et al. fabricated antioxidative polymer hydrogels with thioether groups that possessed conductivity capabilities for SCI treatment [43] . A comprehensive evaluation was undertaken with the aim of enhancing the antioxidant capabilities of Polylysine (PLL) hydrogels.…”

Section: Ros‐targeted Biomaterials For Sci Treatmentmentioning

confidence: 99%

Reactive oxygen species targeted biomaterials for spinal cord injury therapy

Zuo,

Ying,

Huang

et al. 2023

Brain-X

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Spinal cord injuries (SCIs) often cause individuals to suffer from painful illnesses and debilitating disabilities. Excessive reactive oxygen species (ROS) generation in injured tissues hampers treatment effectiveness. Unfortunately, there is presently no established clinical remedy for addressing SCI, particularly the injuries related to ROS. However, the materials science and technology field has made remarkable progress, resulting in the development of a wide range of biomaterials with unique properties for regulating ROS. This review aims to summarize the latest advancements in ROS‐targeted biomaterials designed specifically for the treatment of SCIs. Key scientific challenges in the evolution of ROS‐targeted neuroprotection strategies are also discussed. We anticipate that this comprehensive summary will be valuable to new researchers and highlight specific future avenues of research, contributing to the further advancement of ROS‐targeted biomaterials for SCI treatment.

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Natural small molecule-induced polymer hydrogels with inherent antioxidative ability and conductivity for neurogenesis and functional recovery after spinal cord injury

Cited by 7 publications

References 43 publications

Pluronic F127-Lipoic Acid Adhesive Nanohydrogel Combining with Ce³⁺/Tannic Acid/Ulinastatin Nanoparticles for Promoting Wound Healing

Pluronic F127-Lipoic Acid Adhesive Nanohydrogel Combining with Ce³⁺/Tannic Acid/Ulinastatin Nanoparticles for Promoting Wound Healing

Antioxidant Hydrogels: Antioxidant Mechanisms, Design Strategies, and Applications in the Treatment of Oxidative Stress‐Related Diseases

Reactive oxygen species targeted biomaterials for spinal cord injury therapy

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Natural small molecule-induced polymer hydrogels with inherent antioxidative ability and conductivity for neurogenesis and functional recovery after spinal cord injury

Cited by 7 publications

References 43 publications

Pluronic F127-Lipoic Acid Adhesive Nanohydrogel Combining with Ce3+/Tannic Acid/Ulinastatin Nanoparticles for Promoting Wound Healing

Pluronic F127-Lipoic Acid Adhesive Nanohydrogel Combining with Ce3+/Tannic Acid/Ulinastatin Nanoparticles for Promoting Wound Healing

Antioxidant Hydrogels: Antioxidant Mechanisms, Design Strategies, and Applications in the Treatment of Oxidative Stress‐Related Diseases

Reactive oxygen species targeted biomaterials for spinal cord injury therapy

Contact Info

Product

Resources

About

Pluronic F127-Lipoic Acid Adhesive Nanohydrogel Combining with Ce³⁺/Tannic Acid/Ulinastatin Nanoparticles for Promoting Wound Healing

Pluronic F127-Lipoic Acid Adhesive Nanohydrogel Combining with Ce³⁺/Tannic Acid/Ulinastatin Nanoparticles for Promoting Wound Healing