Natural severe fever with thrombocytopenia syndrome virus infection in domestic cats in Japan

Matsuu, Aya; Momoi, Yasuyuki; Nishiguchi, Akihiro; Noguchi, Keita; Yabuki, Mihoko; Hamakubo, Emu; Take, Maho; Maeda, Ken

doi:10.1016/j.vetmic.2019.06.019

Cited by 62 publications

(68 citation statements)

References 32 publications

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“…Since 2017, a total of 24 pet cats living in western Japan have been diagnosed with SFTSV infection (30). All cats infected with SFTSV showed acute onset of clinical signs.…”

Section: Discussionmentioning

confidence: 99%

Severe Fever with Thrombocytopenia Syndrome, Japan, 2013–2017

Kobayashi¹,

Katô²,

Yamagishi³

et al. 2020

Emerg. Infect. Dis.

106

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S evere fever with thrombocytopenia syndrome (SFTS) is an emerging tickborne infectious disease, identified in 2009 in the rural areas of Hubei and Henan provinces in China (1,2); a total of 7,419 cases were reported from 23 provinces during 2010-2016 (3). SFTS is endemic not only to China but also to South Korea and Japan (4,5). Huaiyangshan banyangvirus (formerly SFTS virus [SFTSV]), the causative agent of SFTS, belongs to the genus Banyangvirus in the family Phenuiviridae. Although the name of the virus has recently been changed from SFTSV to Huaiyangshan banyangvirus by the International Committee on Taxonomy of Viruses (6), the term SFTSV is still used. SFTSV is found in tick species such as Haemaphysalis longicornis, Amblyomma testudinarium, and Ixodes nipponesis in China, South Korea, and Japan (7-9). Antibodies to SFTSV were detected in wild and domestic animals, such as goats, deer, cattle, dogs, and cats, in SFTS-endemic areas of these 3 countries (10-15). SFTSV is thought to circulate in an

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“…Since 2017, a total of 24 pet cats living in western Japan have been diagnosed with SFTSV infection (30). All cats infected with SFTSV showed acute onset of clinical signs.…”

Section: Discussionmentioning

confidence: 99%

Severe Fever with Thrombocytopenia Syndrome, Japan, 2013–2017

Kobayashi¹,

Katô²,

Yamagishi³

et al. 2020

Emerg. Infect. Dis.

106

View full text Add to dashboard Cite

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“…Recently, it has been reported that cats including cheetahs can become infected and ill with SFTSV [10,11]. Furthermore, cases of patients with SFTS infected by sick cats have also been reported [12,13].…”

Section: Introductionmentioning

confidence: 99%

Pathological Characteristics of a Patient with Severe Fever with Thrombocytopenia Syndrome (SFTS) Infected with SFTS Virus through a Sick Cat’s Bite

Tsuru

Suzuki

Murakami

et al. 2021

Viruses

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A woman in her fifties showed symptoms of fever, loss of appetite, vomiting, and general fatigue 2 days after she was bitten by a sick cat, which had later died, in Yamaguchi prefecture, western Japan, in June 2016. She subsequently died of multiorgan failure, and an autopsy was performed to determine the cause of death. However, the etiological pathogens were not quickly identified. The pathological features of the patient were retrospectively re-examined, and the pathology of the regional lymph node at the site of the cat bite was found to show necrotizing lymphadenitis with hemophagocytosis. The pathological features were noted to be similar to those of patients reported to have severe fever with thrombocytopenia syndrome (SFTS). Therefore, the lymph node section was retrospectively tested immunohistochemically, revealing the presence of the SFTS virus (SFTSV) antigen. The sick cat showed similar symptoms and laboratory findings similar to those shown in human SFTS cases. The patient had no history of tick bites, and did not have skin lesions suggestive of these. She had not undertaken any outdoor activities. It is highly possible that the patient was infected with SFTSV through the sick cat’s bite. If a patient gets sick in an SFTS-endemic region after being bitten by a cat, SFTS should be considered in the differential diagnosis.

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“…These data demonstrate the infectivity of SFTSV in these animal species and circulation of SFTSV between ticks and animals in nature. Reported cases of SFTS in cheetahs and domestic cats have shown that nonhuman mammalian species can develop fatal disease similar to human SFTS (11,12). Susceptibility of cats to SFTSV also was confi rmed by experimental SFTSV infection in cats, which caused a high incidence of severe hemorrhagic fever (13).…”

Section: Researchmentioning

confidence: 99%

Histopathological Characterization of Cases of Spontaneous Fatal Feline Severe Fever with Thrombocytopenia Syndrome, Japan

Sakai¹,

Kuwabara²,

Ishijima³

et al. 2021

Emerg. Infect. Dis.

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Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tickborne infectious disease caused by SFTS virus (SFTSV). We report 7 cases of spontaneous fatal SFTS in felines. Necropsies revealed characteristic lesions, including necrotizing lymphadenitis in 5 cases and necrotizing splenitis and SFTSV-positive blastic lymphocytes in all cases. We detected hemorrhagic lesions in the gastrointestinal tract in 6 cases and lungs in 3 cases, suggesting a more severe clinical course of SFTS in felids than in humans. We noted necrotic or ulcerative foci in the gastrointestinal tract in 3 cases, the lung in 2 cases, and the liver in 4 cases. We clarified that blastic lymphocytes are predominant targets of SFTSV and involved in induction of necrotic foci. We also found that thymic epithelial cells were additional targets of SFTSV. These results provide insights for diagnosing feline SFTS during pathological examination and demonstrate the similarity of feline and human SFTS cases.

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Natural severe fever with thrombocytopenia syndrome virus infection in domestic cats in Japan

Cited by 62 publications

References 32 publications

Severe Fever with Thrombocytopenia Syndrome, Japan, 2013–2017

Severe Fever with Thrombocytopenia Syndrome, Japan, 2013–2017

Pathological Characteristics of a Patient with Severe Fever with Thrombocytopenia Syndrome (SFTS) Infected with SFTS Virus through a Sick Cat’s Bite

Histopathological Characterization of Cases of Spontaneous Fatal Feline Severe Fever with Thrombocytopenia Syndrome, Japan

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