Natural seroconversion from HBe-Ag to antibody in chronic hepatitis B infection.

Kawakami, Hiroiku; Takeno, Hiromu; Yamashita, Seiki; Kikkawa, Masaya; Kawamoto, Hiroo; Matsuura, Toshiziro; Suemori, Shoichi; Ikemoto, Yumiko; Seto, Hiroko; Watanabe, Yoshifumi; Takezaki, Eiichi; Nakanishi, Toshio; Kajiyama, Goro; Aimitsu, Shiomi; Orimen, Sigeo; Morio, Koichi

doi:10.2957/kanzo.25.1513

Cited by 2 publications

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“…natural HBeAg clearance and/or seroconversion to anti-HBe was 6-30% in patients with chronic type B hepatitis [Liaw et al, 1983;Kawakami et al, 1984;Okushin et al, 1985;Chen and Sung, 19871, none of our cases had overt hepatitis during the study period; therefore, we infer that pregnancy and delivery indeed exert effects on HBeAg-positive carrier mothers. However, the outcomes were quite different: some improved as revealed by a decrease of HBV-DNA concentrations or HBeAg titers (ten cases), others were almost unchanged (11 cases), and the remaining worsened with increase of HBV-DNA concentrations or HBeAg titers HBV-DNA ward continuous decline of HBV, as indicated by the decreased HBeAg titer and/or HBV-DNA concentration during 1-2 months postpartum.…”

Section: Discussionmentioning

confidence: 95%

Postpartum subsidence of hepatitis B viral replication in hbeag‐positive carrier mothers

Lin¹,

Chen

et al. 1989

Journal of Medical Virology

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To elucidate the effects of pregnancy and delivery on hepatitis B e antigen (HBeAg)-positive carrier mothers, 31 HBeAg-positive carrier mothers were followed-up postpartum 1 year, with 30 HBeAg-positive nonpregnant female carriers as controls. Serum hepatitis B surface antigen (HBsAg), HBeAg titer, and hepatitis B virus (HBV)-DNA concentration were studied at defined intervals. The results revealed that in the control group HBeAg titers and HBV-DNA concentrations fluctuated, whereas the HBsAg titers showed little change, but HBeAg clearance or seroconversion to anti-HBe were not noted on follow-up. In contrast, one carrier mother seroconverted to anti-HBe during pregnancy and the antibody persisted thereafter. Five of the remaining 30 carrier mothers cleared HBeAg postpartum, and among these five cases, one also seroconverted to anti-HBe. In addition, in another five of the 30 cases, the HBV-DNA fell to undetectable level (less than 0.04 ng/ml). All these ten cases had a common tendency of showing a decrease in HBeAg titers and/or HBV-DNA concentrations 1-2 months after delivery. The HBeAg titers and HBV-DNA concentrations in the other 11 cases remained unchanged, whereas the remaining nine cases had increased levels. It is concluded that subsidence of HBV replication is precipitated by delivery in one-third of HBeAg-positive carrier mothers in Taiwan, and this occurs most frequently 1-2 months postpartum.

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Section: Discussionmentioning

confidence: 95%