Natural Selection on Hippocampal Circuitry Underlying Exploratory Behaviour in Mice: Quantitative-Genetic Analysis

Crusio, Wim E.

doi:10.1007/978-94-011-0091-5_17

Cited by 17 publications

(14 citation statements)

References 47 publications

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“…Consequently, one of the processes thought to be associated with exploratory activ ity is what is called latent learning or exploratory learning [10] [11]. Thus the animal acquire informat ion about their environment [12] Till date however, there has not been any study evaluating effects of prolonged admin istration of Artemether on Loco motor and Explo ratory behaviour.The aim o f this study therefore, was to evaluate the effects of Artemether Loco motor and Explo ratory behaviour.…”

Section: Background Informationmentioning

confidence: 99%

Locomotor and Exploratory Behaviour in Mice with Treated Oral Artemether Suspension

Davies¹,

Ekpenyong²,

Nwangwa³

et al. 2013

NEUROSCIENCE

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Prev ious studies with intramuscular Artemether reveal dose dependent neurotoxicity with specific concern on the nuclei of the brain stem. This study was aimed at assessing the effect of oral Artemether suspension on locomotor and exploratory behaviour in mice. The study was conducted using a total of 30 mice randomly d ivided into 3 groups. Group 1 served as the control and was administered with neither drug nor placebo. Groups 2 and 3 were ad min istered with 30mg/ kg/day (low dose) and 60mg/kg/day (high dose) respectively of oral Artemether suspension for 17 days. Behavioural tools used were Open Field Maze, ElevatedPlus maze and Light/Dark t ransition box. Parameters measured were centre square duration/ entries, frequency of rearing, frequency of line crosses, open arm duration / entries and head dips. In the Open Field test, centre square duration and entries were significantly higher in the low dose group but lower in the high dose group compared to the control. The frequency of line crosses in the Open Field test was also significantly lower in the high dose group compared to control. The frequency of rearing was significantly lo wer in high dose group compared to the control in all the 3 behavioural tools used. There was no significant difference between the control and the experimental mice in the frequency of head dips and open arm duration/entries. In conclusion, oral Artemether causes reduce exploratory and locomotor activ ity.

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Section: Background Informationmentioning

confidence: 99%

Locomotor and Exploratory Behaviour in Mice with Treated Oral Artemether Suspension

Davies¹,

Ekpenyong²,

Nwangwa³

et al. 2013

NEUROSCIENCE

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show abstract

“…In this case, mice with more extended projections would show superior processing and hence better spatial learning. This hypothesis is able to explain the data observed in the open field (Crusio, 1995), in the radial maze (Schwegler and Crusio, 1995), in swimming navigation, and perhaps, in two-way avoidance (Lipp and Wolfer, 1995). It has difficulties, however, accounting for the more recently observed correlations between the size of the IIP-MF and Y-maze discrimination learning, in which mice with more extended IIP-MF projections showed superior Y-maze avoidance learning (Schwegler and Lipp, 1995).…”

Section: Behavioral Stability As a Covariate Of Iip-mf Variationsmentioning

confidence: 90%

“…Some studies, however, have found behavioral differences in hippocampus-dependent tasks without associated size differences of the IIP-MF projection Wahlsten et al, 1991;Hoffmann et al, 1992;Roullet and Lassalle, 1992). For detailed reviews, the reader is referred to Crusio (1995), Lipp and Wolfer (1995), Schwegler and Lipp (1995), and Schwegler and Crusio (1995).…”

Section: Introductionmentioning

confidence: 94%

Paw preference and intra-/infrapyramidal mossy fibers in the hippocampus of the mouse

et al. 1996

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The size of the intra-/infrapyramidal mossy fiber projections (IIP-MF) and their left/right asymmetry were assessed in 86 mice of either sex, including 26 animals from two mouse lines bred for strong or weak paw preference, 38 mice of a randomly bred F3 generation derived from an eight-way cross, and 22 mice with variably sized corpora callosa in which only the left hippocampus was measured. Prior to morphometry, all mice were tested for paw preference. In addition, we compared the strain means in paw preference as observed in nine inbred mouse strains with known differences in their IIP-MF distribution. Mice bred for strong paw preference had a 70% larger IIP-MF projection than weakly lateralized and dyscallosal mice; random-bred mice fell in-between the extremes. The individual scores of the strength of paw preference were positively correlated with the extent of the IIP-MF. Among the inbred strains, the extent of the IIP-MF was similarly correlated with the strength of paw preference. The acallosal mice showed a significant negative correlation between extent of the IIP-MF projection and test-retest reliability of paw use. The left-right asymmetry of the IIP-MF was significantly and positively correlated with the direction of paw preference in the entire sample. We conclude that size and asymmetry of the IIP-MF projection are some of the many factors influencing the direction of paw preference and its strength, albeit moderately. We hypothesize that mice with larger IIP-MF projections use a given paw more consistently, being perhaps more resistant to interferences, and that left-right asymmetries of the IIP-MF may bias and/or reinforce an initial choice of a paw. In addition, the data provide another example of correlations between IIP-MF variations and nonspatial behavior.

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“…There are two main reasons why this argument is made. One, alleles of genes that influence any trait under investigation have been selected by natural selection and the influence they exert on the phenotype is the result of evolution, the phylogenetic argument (Crusio, 1995). Two, analysis of the mechanisms underlying the phenotypical characteristics can only be conducted appropriately if the characteristics are not artificial constructs but are defined in a biologically meaningful manner.…”

Section: Laboratory Animals: Efficient Tools Of Discoverymentioning

confidence: 99%

“…Two, analysis of the mechanisms underlying the phenotypical characteristics can only be conducted appropriately if the characteristics are not artificial constructs but are defined in a biologically meaningful manner. Although the question of what is biologically meaningful is not always easy to answer, in case of behaviour, the above argument translates to choosing methods that allow the quantification of natural, species-specific, responses that are the product of the studied organism and not of the experimenter's subjective bias, the phenogenetic argument (Crusio, 1995). Briefly, one needs to design his/her experiments according to the natural behaviour of the studied species.…”

Section: Laboratory Animals: Efficient Tools Of Discoverymentioning

confidence: 99%

Zebrafish, a Potential Novel Research Tool for the Analysis and Modeling of Anxiety

Gerlai

2011

Different Views of Anxiety Disorders

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Natural Selection on Hippocampal Circuitry Underlying Exploratory Behaviour in Mice: Quantitative-Genetic Analysis

Cited by 17 publications

References 47 publications

Locomotor and Exploratory Behaviour in Mice with Treated Oral Artemether Suspension

Locomotor and Exploratory Behaviour in Mice with Treated Oral Artemether Suspension

Paw preference and intra-/infrapyramidal mossy fibers in the hippocampus of the mouse

Zebrafish, a Potential Novel Research Tool for the Analysis and Modeling of Anxiety

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