2000
DOI: 10.1073/pnas.97.14.7911
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Natural selection mapping of the warfarin-resistance gene

Abstract: In theory, genes under natural selection can be revealed by unique patterns of linkage disequilibrium (LD) and polymorphism at physically linked loci. However, given the effects of recombination and mutation, the physical extent and persistence of LD patterns in natural populations is uncertain. To assess the LD signature of selection, we survey variation in 26 microsatellite loci spanning an Ϸ32-cM region that includes the warfarin-resistance gene (Rw) in five wild rat populations having resistance levels bet… Show more

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Cited by 105 publications
(81 citation statements)
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References 47 publications
(47 reference statements)
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“…Significant linkage disequilibria between loci that are not closely linked have been found in other species that have been subject to bottlenecks and/or strong selection (Ledig et al, 1999;Yan et al, 1999;Kohn et al, 2000;Sharbel et al, 2000;McRae et al, 2002;Sinervo and Clobert, 2003;Hansson et al, 2004). Although LD is expected to decay at a rate dependent on the recombination fraction, and to be maintained only for very closely linked loci, these results show that linkage disequilibria may be far more common in natural populations than is generally assumed, and the loci apparently affected by selection may well be marking selection in large genome regions including many loci that are not necessarily closely linked.…”
Section: Tests For Selectionmentioning
confidence: 99%
“…Significant linkage disequilibria between loci that are not closely linked have been found in other species that have been subject to bottlenecks and/or strong selection (Ledig et al, 1999;Yan et al, 1999;Kohn et al, 2000;Sharbel et al, 2000;McRae et al, 2002;Sinervo and Clobert, 2003;Hansson et al, 2004). Although LD is expected to decay at a rate dependent on the recombination fraction, and to be maintained only for very closely linked loci, these results show that linkage disequilibria may be far more common in natural populations than is generally assumed, and the loci apparently affected by selection may well be marking selection in large genome regions including many loci that are not necessarily closely linked.…”
Section: Tests For Selectionmentioning
confidence: 99%
“…Positive directional selection leads to reduced variability and increased LD in the respective region (1)(2)(3)(4)(5)(6), and the so-called selective sweep regions provide clues to genes that have been subjects of evolutionary forces as well as selection by humans. Recently, Clark et al (7) characterized a selective sweep in the promoter region of teosinte branched1 (tb1).…”
mentioning
confidence: 99%
“…Their high informativeness and the cost-effective typing has made microsatellites the marker of choice for many hitchhiking mapping studies. The emerging picture from all of the various studies was that genome scans are a suitable tool for the identification of putatively selected genomic regions (Kohn et al 2000;Harr et al 2002;Vigouroux et al 2002;Wootton et al 2002;Kayser et al 2003;Nair et al 2003;Schlenke and Begun 2004; Schö fl and Schlö tterer 2004; Ihle et al 2006).…”
mentioning
confidence: 99%