Natural Scaffolds Used for Liver Regeneration: A Narrative Update

Vazirzadeh, Masoud; Azarpira, Negar; Davoodi, Parsa; Vosough, Massoud; Ghaedi, Kamran

doi:10.1007/s12015-022-10362-8

Cited by 6 publications

(3 citation statements)

References 124 publications

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“…However, natural scaffolds often lack the mechanical properties required for an ideal tissue repair scaffold and need to be modified with other compounds, such as galactose. Typically, natural scaffolds are fabricated in the form of fibers, powders, 3D printed structures, and sponges [42]. Chitosan is an excellent candidate for hemostatic scaffold synthesis due to its antimicrobial and hemostatic properties.…”

Section: Liver Stent Materialsmentioning

confidence: 99%

Advancement on Digestive Tract Biomedical Stents, A Review

Sun,

Wang,

et al. 2023

JFBI

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Biomedical stents for the digestive tract address many of the limitations associated with traditional surgical treatments for gastrointestinal diseases. This paper provides a review of the performance requirements, complications, and limitations of stent materials in the treatment of common digestive tract diseases. The advantages and disadvantages of different materials and processing technologies for digestive tract stents are discussed. Furthermore, considering the diverse requirements for ideal alimentary canal stent materials, the challenges that require further research are outlined in detail, providing strategic references for the development of biomedical stents for the digestive tract.

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Section: Liver Stent Materialsmentioning

confidence: 99%

Advancement on Digestive Tract Biomedical Stents, A Review

Sun,

Wang,

et al. 2023

JFBI

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“…Scaffolds made of different biocompatible materials (synthetic or natural), which provide conditions similar to the native extracellular matrix (ECM) of the liver, have helped advance the knowledge of liver regeneration [ 66 , 67 ]. The decellularization of the liver, for instance, provides a scaffold that maintains the native ECM and the hepatic vasculature that could be used in repopulation experiments to study liver regeneration.…”

Section: Strategies To Face Current Challenges In Clinical Practicementioning

confidence: 99%

The Influence of Interdisciplinary Work towards Advancing Knowledge on Human Liver Physiology

Delgado–Coello

Navarro-Alvarez

Mas‐Oliva

2022

Cells

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The knowledge accumulated throughout the years about liver regeneration has allowed a better understanding of normal liver physiology, by reconstructing the sequence of steps that this organ follows when it must rebuild itself after being injured. The scientific community has used several interdisciplinary approaches searching to improve liver regeneration and, therefore, human health. Here, we provide a brief history of the milestones that have advanced liver surgery, and review some of the new insights offered by the interdisciplinary work using animals, in vitro models, tissue engineering, or mathematical models to help advance the knowledge on liver regeneration. We also present several of the main approaches currently available aiming at providing liver support and overcoming organ shortage and we conclude with some of the challenges found in clinical practice and the ethical issues that have concomitantly emerged with the use of those approaches.

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“…To date, both natural and synthetic materials are used to realize 3D cell systems [ [19] , [20] , [21] ]. Natural materials (i.e., collagen, gelatin, chitosan, HA, heparin alginate, silk and decellularized tissue matrices) are inherently biocompatible exhibiting good cellular interactions, low immunogenicity, and mild antigenic properties, but show poor mechanical properties, high production costs, and low reproducibility [ [22] , [23] , [24] , [25] ]. On the other hand, synthetic polymers (i.e.…”

Section: Introductionmentioning

confidence: 99%