Natural Rubber - Propolis Membrane Improves Wound Healing in Second-Degree Burning Model

Krupp, Tamires; Santos, Bruna Daniele dos; Gama, Loyane Almeida; Silva, Josmary Rodrigues; Arrais-Silva, Wagner Welber; Souza, Nara C. de; Américo, Madileine Francely; Souto, Paula Cristina de Souza

doi:10.1016/j.ijbiomac.2019.03.147

Cited by 33 publications

(23 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Noteworthy is the use of honey as a wound-healing agent since it promotes a multifaceted and safe healing activity for all skin wounds [13]. Moreover, either ethanolic [19] or aqueous [20] extract of propolis accelerates wound healing and have synergistic action with honey [21,22].…”

Section: Resultsmentioning

confidence: 99%

“…Wound area reduction up to complete healing (wound closure) was achieved with topical application of honey in surgical induced non septic wounds by the 10 th day [41], 12 th day [42], 14 th day [43], 16 th day [44], 21 th day [45], 28 th [46] or by the day 28 th in clinical septic wounds [4,30]. Also, topical application of propolis powder by the 21 th day [47,48], its ethyl extract by the 25 th day [15], its ethyl extract in association with bacterial cellulose by the 14 th day [49] or addition of its aqueous extract to rubber membrane by the 10 th day [20].…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, honey stimulates angiogenesis, promoting an efficacious skin-remodeling phase [13,55] and tensile strength [56]. Propolis induces wound healing with collagen production, angiogenesis, re-epithelization accelerating the healing process [49] and tissue repair without the curative switch [20]. Even in bone marrow mesenchymal stromal cells, propolis enhances cell proliferation and tissue regeneration [57].…”

Section: Resultsmentioning

confidence: 99%

“…The present histopathological results revealed that all honey treated septic wounds had different re-epithelization process indicating variant healing potencies (figures [5][6][7][8][9][10][11][12][13][14] Wound healing is a complex and systematic process, in terms of histopathology it includes three phases including inflammation, proliferation, and remodeling [58]. Honey increases activity of fibroblasts [29] and collagen formation [20,59]. Honey contains high levels of glycine, methionine, arginine, and proline, which are all necessary for collagen formation and fibroblast deposition, which are essential factors needed for healing [6].…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Apitherapy of Septic Metacarpal and Metatarsal Wounds (An Experimental Study on Donkeys)

Hamouda¹,

Kuraa²,

El-Samieh³

et al. 2019

CMR

View full text Add to dashboard Cite

Non-healed wounds are a significant problem in the healthcare system of the distal portions of the limbs. Nine types of honey were tested for wound healing judged by clinical gross healing parameters, rate of wound contraction and sings of epithelization histopathologically. Rounded full thickness skin wounds (1.5cm diameter) were performed at the distal portion of limbs. The wounds were infected by standard dose of MRSA (methicillin resistance Staph. aureus) for 72 hours. The tested types of honey were tested for MIC & MBC against clinical MRSA strain. Different types of honey were applied unprocessed as daily topical wound dressing for the infected wounds. Propolis with black seed honey followed by Hadramout sidr honey, then Egyptian sidr honey proved to have the most antimicrobial activity. Clinical healing appearance revealed that propolis with black seed honey, Egyptian sidr honey and Hadramout sidr honey showed the most preferable clinical parameters (gross appearance and rate of wound contraction), and histopathologically achieved the best healing epithelization 28 days after treatment. The study concluded that among different nine honey types retailed in Egyptian markets, all tested honey types had wound healing activities but with different potencies. Propolis with black seed, Egyptian sidr honey and Hadramout honey were the most potent with highly significance differences (P < 0.01), since achieving the most wound contraction rates, rapid epithelization post 28 days rather than the least MICs & MBCs values. While the marjoram and clover honey were the least effective.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Apitherapy of Septic Metacarpal and Metatarsal Wounds (An Experimental Study on Donkeys)

Hamouda¹,

Kuraa²,

El-Samieh³

et al. 2019

CMR

View full text Add to dashboard Cite

show abstract

“…Literature has reported the antibacterial activity of red propolis due to its complex and varying chemical composition 9 which includes flavonoids and aromatic acids, as well as different types of terpenoids 10,11 . It is constituted of exudates from floral shoots and buds of various plants, presenting many benefits to human health, like antioxidant, anti-inflammatory and regenerating properties [9][10][11][12] . Red propolis (RP) was chosen to be studied in this work, as it is a product that can be only found in Brazil, so it represents a native resource that can help in public health.…”

Section: Introductionmentioning

confidence: 99%

Natural Rubber Films Incorporated with Red Propolis and Silver Nanoparticles Aimed for Occlusive Dressing Application

et al. 2021

View full text Add to dashboard Cite

In this work, NRL films were enriched with red propolis and silver nanoparticles with the aim of obtaining dressings with bactericide properties. To improve the properties of these materials, plasma treatment was also applied to the films. Cytotoxic effects were evaluated by MTT and agar diffusion assays on secondary and stem cells. Determination of cell behavior on the films were assessed by EDS and FEG-SEM. In general, the plasma modified NRL films presented hydrophilic character, favorable condition for biomedical applications. RBS results showed that silver is probably in nanoparticulate form. MTT assays revealed that non-cytotoxic effects were observed for all the samples extracts. Either the plasma treatment or silver deposition were effective in sterilizing the samples and modifying their surfaces. It was demonstrated in this in vitro study that ADSCs associated with NRL films enriched with propolis should be considered promising for application in the healing of occlusive wounds.

show abstract

Therapeutic potential of propolis in alleviating inflammatory response and promoting wound healing in skin burn

Manginstar,

Tallei,

Niode

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

Burns can cause inflammation and delayed healing, necessitating alternative therapies due to the limitations of conventional treatments. Propolis, a natural bee‐produced substance, has shown promise in facilitating burn healing. This literature review provides a comprehensive overview of propolis' mechanisms of action, wound‐healing properties, and its application in treating skin burns. Propolis contains bioactive compounds with antimicrobial, antioxidant, and anti‐inflammatory properties, making it a promising candidate for managing skin burn injuries. It helps prevent infections, neutralize harmful free radicals, and promote a well‐balanced inflammatory response. Moreover, propolis aids in wound closure, tissue regeneration, collagen synthesis, cellular proliferation, and angiogenesis, contributing to tissue regeneration and remodeling. The article discusses various propolis extracts, extraction methods, chemical composition, and optimized formulations like ointments and creams for burn wound treatment. Considerations regarding dosage and safety are addressed. Further research is needed to fully understand propolis' mechanisms, determine optimal formulations, and establish suitable clinical dosages. Nevertheless, propolis' natural origin and demonstrated benefits make it a compelling avenue for burn care exploration, potentially complementing existing therapies and improving burn management outcomes.

show abstract

Natural Rubber - Propolis Membrane Improves Wound Healing in Second-Degree Burning Model

Cited by 33 publications

References 43 publications

Apitherapy of Septic Metacarpal and Metatarsal Wounds (An Experimental Study on Donkeys)

Apitherapy of Septic Metacarpal and Metatarsal Wounds (An Experimental Study on Donkeys)

Natural Rubber Films Incorporated with Red Propolis and Silver Nanoparticles Aimed for Occlusive Dressing Application

Therapeutic potential of propolis in alleviating inflammatory response and promoting wound healing in skin burn

Contact Info

Product

Resources

About