Natural reversal of cavefish heart asymmetry is controlled by Sonic Hedgehog effects on the left-right organizer
Mandy Ng,
Li Ma,
Janet Shi
et al.
Abstract:The direction of left-right (L-R) visceral asymmetry is conserved in vertebrates. Deviations of the asymmetric pattern are rare, and the underlying mechanisms are not understood. Here we use the teleostAstyanax mexicanus, a single species consisting of surface fish with normal left-oriented heart asymmetry and cavefish with high levels of reversed right-oriented heart asymmetry, to explore natural changes in L-R determination. We show that Sonic Hedgehog (Shh) signaling is increased at the posterior midline, K… Show more
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