Natural remedies and functional foods as angiogenesis modulators

Varol, Mehmet

doi:10.1016/b978-0-12-816151-7.00001-6

Cited by 3 publications

(2 citation statements)

References 247 publications

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“…Then, all the microalgae extracts at 50, 100 and 200 mg L −1 , with a contact time of 48 h, were added to cell monolayers of PC‐3. VEGF in the supernatant was measured by ELISA 21 . VEGF express protein human recombinant was negative control (CTRL–) and grape seed extract was positive control (CTRL+).…”

Section: Methodsmentioning

confidence: 99%

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Antioxidant potential and antiangiogenic activity of Tetraselmis suecica grown in a semicontinuous culture

Rentería-Mexía

Ulloa-Mercado

Gortáres‐Moroyoqui

et al. 2022

J of Chemical Tech & Biotech

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BACKGROUND A main advantage of microalgae cultivation is its capacity to produce metabolites of biotechnological interest through modification of growth conditions. The aim was to evaluate the effect of strontium addition (Sr) to the culture medium and culture scale‐up of Tetraselmis suecica on antioxidant capacity and antiangiogenic activity. RESULTS Antiradical activity in extracts through the DPPH (α, α‐diphenyl‐β‐picrylhydrazyl free radical) scavenging method was higher for a 5‐L reactor (81.9 ± 2.5%) than for a 80‐L reactor (60 ± 4.6%), and through the TEAC (Trolox equivalent antioxidant capacity) method, the activity measures were 1.38 ± 0.05 and 1.12 ± 0.05 mmol Trolox, respectively. Lipid peroxidation β‐carotene bleaching reached the highest activity coefficients for the 80‐L reactor (ethanol extract 724 ± 35 AAC). Antioxidant activity was similar with and without Sr, although it was affected by the scale‐up. Extractable solids were maximized in the 80‐L reactor (350 ± 6 mg g−1 for methanol–water), whereas phenolic compounds were higher for ethanol extracts (5.5 ± 0.1 mg GAE g−1 for 5‐ and 80‐L reactors, without Sr addition). The antiangiogenic activity was improved in the methanol extract by ≈50% more than the negative control. CONCLUSION The antioxidant activity of T. suecica biomass can be improved using different culture scale‐ups and solvents during extraction, increasing the production of natural sources of antioxidant and antiangiogenic compounds for their use in food, health and cosmetics. © 2022 Society of Chemical Industry (SCI).

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Section: Methodsmentioning

confidence: 99%

“…VEGF in the supernatant was measured by ELISA. 21 VEGF express protein human recombinant was negative control (CTRL-) and grape seed extract was positive control (CTRL+).…”

mentioning

confidence: 99%