Natural Radioprotective Agents: An Overview

Venkatachalam, S. R.; Chattopadhyay, Subrata

doi:10.2174/1385272053174930

Cited by 22 publications

(12 citation statements)

References 90 publications

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“…For a successful combined chemo-and radiotherapy approach, rapid or significant drops in radioprotective metabolites (9,12,20,35,37) and in key metabolites involved in cellular energy generation should be observed in ACCA-treated U-87MG glioma cells. Thus, we examined the ACCA-treated cells at multiple time points for changes in antioxidants/ radioprotectants (i.e., changes in taurine and glutathione).…”

Section: Mrs Experimentsmentioning

confidence: 99%

Metabolic Remodeling of Malignant Gliomas for Enhanced Sensitization During Radiotherapy

Colen¹,

Seraji‐Bozorgzad²,

Marples³

et al. 2006

Neurosurgery

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OBJECTIVE-To investigate a novel method to enhance radiosensitivity of gliomas via modification of metabolite flux immediately before radiotherapy. Malignant gliomas are highly glycolytic and produce copious amounts of lactic acid, which is effluxed to the tumor microenvironment via lactate transporters. We hypothesized that inhibition of lactic acid efflux would alter glioma metabolite profiles, including those that are radioprotective. 1 H magnetic resonance spectroscopy (MRS) was used to quantify key metabolites, including those most effective for induction of low-dose radiation-induced cell death.METHODS-We inhibited lactate transport in U87-MG gliomas with α-cyano-4-hydroxycinnamic acid (ACCA). Flow cytometry was used to assess induction of cell death in treated cells. Cells were analyzed by MRS after ACCA treatment. Control and treated cells were subjected to low-dose irradiation, and the surviving fractions of cells were determined by clonogenic assays.RESULTS-MRS revealed changes to intracellular lactate on treatment with ACCA. Significant decreases in the metabolites taurine, glutamate, glutathione, alanine, and glycine were observed, along with inversion of the choline/phosphocholine profile. On exposure to low-dose radiation, ACCA-pretreated U-87MG cells underwent rapid morphological changes, which were followed by apoptotic cell death.

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Section: Mrs Experimentsmentioning

confidence: 99%

Metabolic Remodeling of Malignant Gliomas for Enhanced Sensitization During Radiotherapy

Colen¹,

Seraji‐Bozorgzad²,

Marples³

et al. 2006

Neurosurgery

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“…In this context, several authors have reviewed the prospective application of traditional medicinal plants which are known to contain anti-inflammatory, antioxidant, and immunomodulatory compounds (Arora et al, 2005; Venkatachalam and Chattopadhyay, 2005; Jagetia, 2007). Again, plant-derived polyphenolic compounds with radiosensitizing property have been extensively reviewed elsewhere (Garg et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

The Prospective Role of Plant Products in Radiotherapy of Cancer: A Current Overview

Hazra¹,

Ghosh²,

Kumar³

et al. 2012

Front. Pharmacol.

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Treatment of cancer often requires exposure to radiation, which has several limitations involving non-specific toxicity toward normal cells, reducing the efficacy of treatment. Efforts are going on to find chemical compounds which would effectively offer protection to the normal tissues after radiation exposure during radiotherapy of cancer. In this regard, plant-derived compounds might serve as “leads” to design ideal radioprotectors/radiosensitizers. This article reviews some of the recent findings on prospective medicinal plants, phytochemicals, and their analogs, based on both in vitro and in vivo tumor models especially focused with relevance to cancer radiotherapy. Also, pertinent discussion has been presented on the molecular mechanism of apoptotic death in relation to the oxidative stress in cancer cells induced by some of these plant samples and their active constituents.

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“…However, there is a dearth of information on the radioprotective effects of flavonoids isolated from algae. Flavonoids, such as luteolin, hesperetin, quercetin, rutin, and kaempferol, and flavone glycosides, such as orientin and vicenin, isolated from terrestrial plants have shown potential radioprotective effects (Venkatachalam and Chattopadhyay 2005). Of these flavonoids luteolin, quercetin, orientin, and vicenin have been reported in marine algae (Markham andPorter 1969, Fernando et al 2016a).…”

Section: Ionizing Radiation-induced Reactive Oxygen Species Generatiomentioning

confidence: 99%

Potential applications of radioprotective phytochemicals from marine algae

Oh¹,

Fernando²,

Jeon³

2016

ALGAE

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The use of ionizing radiation and radioactive elements is becoming increasingly popular with the rapid developments in nuclear technology, radiotherapy, and radio diagnostic methods. However, ionizing radiation can directly or indirectly cause life-threatening complications such as cancer, radiation burns, and impaired immunity. Environmental contamination with radioactive elements and the depletion of ozone layer also contribute to the increased levels of radiation exposure. Radioprotective natural products have particularly received attention for their potential usefulness in counteracting radiation-induced damage because of their reduced toxicity compared with most drugs currently in use. Moreover, radioprotective substances are used as ingredients in cosmetic formulations in order to provide protection against ultraviolet radiation. Over the past few decades, the exploration of marine algae has revealed the presence of radioprotective phytochemicals, such as phlorotannins, polysaccharides, carotenoids and other compounds. With their promising radioprotective effects, marine algae could be a future source for discovering potential radioprotective substances for development as useful in therapeutics.

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Natural Radioprotective Agents: An Overview

Cited by 22 publications

References 90 publications

Metabolic Remodeling of Malignant Gliomas for Enhanced Sensitization During Radiotherapy

Metabolic Remodeling of Malignant Gliomas for Enhanced Sensitization During Radiotherapy

The Prospective Role of Plant Products in Radiotherapy of Cancer: A Current Overview

Potential applications of radioprotective phytochemicals from marine algae

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