Natural PTP1B Inhibitors from broussonetia papyrifera

Chen, Rong Min; Hu, Li; An, Tian Ying; Li, Jia; Shen, Qiang

doi:10.1016/s0960-894x(02)00757-6

Cited by 92 publications

(20 citation statements)

References 11 publications

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“…In China, the leaves have been used in folk medicine against chronic prostatitis, and the fruit has been used to treat impotence and ophthalmic disorders, the efficacy of which has been proved by pharmacological experiments [1]. Various compounds identified in this plant have been shown to inhibit lipid peroxidation [2], have antiplatelet effects [3], and inhibit the activities of the protein tyrosine phosphatase 1b (PTP1B) enzyme and aromatase [1], [4].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antioxidant Activities of Broussonetia papyrifera Fruits

Sun¹,

Liu²,

Zhang³

et al. 2012

PLoS ONE

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Fruits of Broussonetia papyrifera from South China were analyzed for their total chemical composition, and antioxidant activities in ethanol and aqueous extracts. In the fruit of this plant, the crude protein, crude fat and carbohydrates was 7.08%, 3.72% and 64.73% of dry weight, respectively. The crude protein, crude fat and carbohydrates were 15.71%, 20.51% and 36.09% of dry weight, respectively. Fatty acid and amino acid composition of the fruit were analyzed. Unsaturated fatty acid concentration was 70.6% of the total fatty acids. The percentage of the essential amino acids (EAAs) was 40.60% of the total amino acids. Furthermore, B. papyrifera fruit are rich in many mineral elements and vitamins. Total phenolic content was assessed using the Folin-Ciocalteau assay, whereas antioxidant activities were assessed by measuring the ability of the two extracts to scavenge DPPH radicals, inhibit peroxidation, and chelate ferric ions. Their reducing power was also assessed. Results indicated that the aqueous extract of B. papyrifera was a more potent reducing agent and radical-scavenger than the ethanol extract. GC–MS analysis of the ethanol extract showed the presence of some acid-containing compounds. The changes in total phenolic content and antioxidant capacity in B. papyrifera from four different regions grown under normal conditions were assessed. The antioxidant activity of different extracts was positively associated with their total phenolic content. These results suggest that the fruit of B. papyrifera could be used in dietary supplement preparations, or as a food additive, for nutritional gain, or to prevent oxidation in food products.

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Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antioxidant Activities of Broussonetia papyrifera Fruits

Sun¹,

Liu²,

Zhang³

et al. 2012

PLoS ONE

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“…These studies show that chalcones are effective antihyperglycemic or hypoglycemic agents as much in vitro as in vivo experimental models [8,9,14]. It has been reported that sulfonamide chalcones act as a potent new class of a-glucosidase inhibitors [10,15].…”

Section: Introductionmentioning

confidence: 88%

“…It is well known that different substituents at different positions on the core structure of chalcones ( Fig. 1) determine biological activity as well as the specificity of action [8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Antihyperglycemic activity of naphthylchalcones

Damazio

Zanatta

Cazarolli

et al. 2010

European Journal of Medicinal Chemistry

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“…The leaves, twig roots and barks of this plant are widely used to treat gynecological bleeding, dropsy, dysentery diseases as a folk medicine in China (Feng et al, 2008). Various types of flavonoids are the major constituents of this plant and some of which exhibited strong tyrosinase inhibitory , aromatase inhibitorory (Lee et al, 2001), antifungal (Takasugi et al, 1980(Takasugi et al, , 1984, secretory phospholipase A-2 inhibitory (Kwak et al, 2003), PTP1B enzyme inhibitory (Chen et al, 2002;Nguyen et al, 2012), antimicrobial, cytotoxic (Sohn et al, 2004), antiplatelet (Lin et al, 1996), antioxidant and inducible nitric oxide synthase suppressing activities (Cheng et al, 2001). However, the effects and the underlying mechanisms of the flavonoids from B. papyrifera in human cancer have never been studied.…”

Section: Introductionmentioning

confidence: 99%

Breast Cancer Stem Cells in Antiestrogen Resistance

Wang¹,

Deng²,

Guo³

2013

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Natural PTP1B Inhibitors from broussonetia papyrifera

Cited by 92 publications

References 11 publications

Chemical Composition and Antioxidant Activities of Broussonetia papyrifera Fruits

Chemical Composition and Antioxidant Activities of Broussonetia papyrifera Fruits

Antihyperglycemic activity of naphthylchalcones

Breast Cancer Stem Cells in Antiestrogen Resistance

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