Natural Progression of Helicobacter pylori-Negative Gastritis with Lymphoid Follicles in Children: Prospective Evaluation and Outcome

Richter, Vered; Mendlovic, Sonia; Shalem, Tzipi; Eindor-Abarbanel, Adi; Shirin, Haim; Broide, Efrat

doi:10.5152/tjg.2021.20595

Cited by 1 publication

(1 citation statement)

References 15 publications

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“…The inflammatory infiltrate was less severe in H pylori‐negative gastritis but in 51.3% of these patients, lymphoid follicles were present (113). In a follow‐up study carried by the same group, out of 8 children with a mean follow‐up of 25.6months, 3 had chronic gastritis with lymphoid follicles, 4 had resolution of the gastritis but still had follicles, and 1 patient had resolution of both findings (114). Still, the clinical relevance and prognosis of this entity are unknown and warrant further research.…”

Section: Resultsmentioning

confidence: 99%

Helicobacter pylori‐negative Chronic Gastritis in Children

Assa

Borrelli

Broekaert

et al. 2022

J. pediatr. gastroenterol. nutr.

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Objectives:To systematically review the current evidence on Helicobacter pylori-negative chronic gastritis including natural history, available therapies and outcomes.Methods:Articles providing data on the prevalence, treatment or outcomes of Helicobacter pylori-negative gastritis were identified through a systematic search in the MEDLINE and EMBASE databases. All original research articles from human studies until October 31, 2021, were included.Results:A total of 54 studies were included consisted of eosinophilic gastritis (n = 9), autoimmune gastritis (n = 11), collagenous gastritis (n = 16), focally enhanced gastritis (n = 6), lymphocytic gastritis (n = 5) and other causes including idiopathic gastritis and chronic renal failure related (n = 7). Most of the included studies were either cross-sectional or longitudinal cohorts except for collagenous gastritis, which mainly included case reports and case series. The prevalence of paediatric eosinophilic gastritis ranges between 5 and 7/100,000 and patients have generally favourable outcome with 50% to 70% clinical and histological response to either corticosteroids or elimination diets. Autoimmune gastritis and collagenous gastritis are extremely rare entities, commonly present with refractory iron deficiency anaemia, while lymphocytic gastritis is relatively common (10%–45%) in children with coeliac disease. Data on treatments and outcomes of autoimmune, collagenous, and focally enhanced gastritis are lacking with limited data implying poor response to therapy in the former 2 diagnoses.Conclusions:Helicobacter pylori-negative gastritis is uncommonly reported, mainly in small cohorts, mixed adult-paediatric cohorts or as sporadic case reports. As common symptoms are not specific, thus not always result in an endoscopic evaluation, the true prevalence of these distinct disorders may be underestimated, and thus under reported.

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Section: Resultsmentioning

confidence: 99%