“Natural” progesterone: information on fetal effects

Golub, Mari S.; Kaufman, Farla L.; Campbell, Marlissa; Li, Ling‐Hong; Donald, James M.

doi:10.1002/bdrb.20089

Cited by 15 publications

(9 citation statements)

References 142 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that the usage of progesterone during the first trimester of pregnancy can lead to masculinization of a female fetus, congenital heart and brain malformations [ 78 ]. Yet, in large-scale studies, a clear relationship between progesterone and fetal anomalies has not been elucidated [ 79 80 ].…”

Section: Maternal-fetal Safety and Side Effectsmentioning

confidence: 99%

“…Yet, in large-scale studies, a clear relationship between progesterone and fetal anomalies has not been elucidated [ 79 80 ]. The Food and Drug Administration (FDA) classified natural micronized progesterone medications as category B for pregnancy [ 78 ]. A study from NICHD, which used 17α-OHPC, demonstrated no difference between the progesterone-treated and the control groups in terms of miscarriage and stillbirth [ 12 ].…”

Section: Maternal-fetal Safety and Side Effectsmentioning

confidence: 99%

See 1 more Smart Citation

Use of progesterone supplement therapy for prevention of preterm birth: review of literatures

Choi

2017

Obstet Gynecol Sci

View full text Add to dashboard Cite

Preterm birth (PTB) is one of the most common complications during pregnancy and it primarily accounts for neonatal mortality and numerous morbidities including long-term sequelae including cerebral palsy and developmental disability. The most effective treatment of PTB is prediction and prevention of its risks. Risk factors of PTB include history of PTB, short cervical length (CL), multiple pregnancies, ethnicity, smoking, uterine anomaly and history of curettage or cervical conization. Among these risk factors, history of PTB, and short CL are the most important predictive factors. Progesterone supplement therapy is one of the few proven effective methods to prevent PTB in women with history of spontaneous PTB and in women with short CL. There are 2 types of progesterone therapy currently used for prevention of PTB: weekly intramuscular injection of 17-alpha hydroxyprogesterone caproate and daily administration of natural micronized progesterone vaginal gel, vaginal suppository, or oral capsule. However, the efficacy of progesterone therapy to prevent PTB may vary depending on the administration route, form, dose of progesterone and indications for the treatment. This review aims to summarize the efficacy and safety of progesterone supplement therapy on prevention of PTB according to different indication, type, route, and dose of progesterone, based on the results of recent randomized trials and meta-analysis.

show abstract

Section: Maternal-fetal Safety and Side Effectsmentioning

confidence: 99%

Section: Maternal-fetal Safety and Side Effectsmentioning

confidence: 99%

Use of progesterone supplement therapy for prevention of preterm birth: review of literatures

Choi

2017

Obstet Gynecol Sci

View full text Add to dashboard Cite

show abstract

“…If this happens in neonates, its effects could be excitotoxic [3]–[7]. The literature does offer discussions of some potential fetal and early postnatal effects of endogenous and exogenous progesterone or progestins [31], [32], [34], [35], but there is still no clear consensus about progesterone safety in very young brain-injured subjects.…”

Section: Introductionmentioning

confidence: 99%

Progesterone Treatment Shows Benefit in a Pediatric Model of Moderate to Severe Bilateral Brain Injury

et al. 2014

View full text Add to dashboard Cite

PurposeControlled cortical impact (CCI) models in adult and aged Sprague-Dawley (SD) rats have been used extensively to study medial prefrontal cortex (mPFC) injury and the effects of post-injury progesterone treatment, but the hormone's effects after traumatic brain injury (TBI) in juvenile animals have not been determined. In the present proof-of-concept study we investigated whether progesterone had neuroprotective effects in a pediatric model of moderate to severe bilateral brain injury.MethodsTwenty-eight-day old (PND 28) male Sprague Dawley rats received sham (n = 24) or CCI (n = 47) injury and were given progesterone (4, 8, or 16 mg/kg per 100 g body weight) or vehicle injections on post-injury days (PID) 1–7, subjected to behavioral testing from PID 9–27, and analyzed for lesion size at PID 28.ResultsThe 8 and 16 mg/kg doses of progesterone were observed to be most beneficial in reducing the effect of CCI on lesion size and behavior in PND 28 male SD rats.ConclusionOur findings suggest that a midline CCI injury to the frontal cortex will reliably produce a moderate TBI comparable to what is seen in the adult male rat and that progesterone can ameliorate the injury-induced deficits.

show abstract

“…Moreover, P4 and E2 are cholesterol-derived, phylogenetically old steroid hormones [ 59 ]. They are synthesized during steroid hormone metabolization within several cell types such as the corpus luteum and placenta [ 60 ]. In a recent review [ 61 ], a novel insight into the interactions between folate and the lipid metabolism was put forward.…”

Section: Discussionmentioning

confidence: 99%

Folate Deficiency Could Restrain Decidual Angiogenesis in Pregnant Mice

Gao

Liu

et al. 2015

Nutrients

View full text Add to dashboard Cite

The mechanism of birth defects induced by folate deficiency was focused on mainly in fetal development. Little is known about the effect of folate deficiency on the maternal uterus, especially on decidual angiogenesis after implantation which establishes vessel networks to support embryo development. The aim of this study was to investigate the effects of folate deficiency on decidual angiogenesis. Serum folate levels were measured by electrochemiluminescence. The status of decidual angiogenesis was examined by cluster designation 34 (CD34) immunohistochemistry and the expression of angiogenic factors, including vascular endothelial growth factor A (VEGFA), placental growth factor (PLGF), and VEGF receptor 2 (VEGFR2) were also tested. Serum levels of homocysteine (Hcy), follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), progesterone (P4), and estradiol (E2) were detected by Enzyme-linked immunosorbent assay. The folate-deficient mice had a lower folate level and a higher Hcy level. Folate deficiency restrained decidual angiogenesis with significant abnormalities in vascular density and the enlargement and elongation of the vascular sinus. It also showed a reduction in the expressions of VEGFA, VEGFR2, and PLGF. In addition, the serum levels of P4, E2, LH, and PRL were reduced in folate-deficient mice, and the expression of progesterone receptor (PR) and estrogen receptor α (ERα) were abnormal. These results indicated that folate deficiency could impaire decidual angiogenesis and it may be related to the vasculotoxic properties of Hcy and the imbalance of the reproductive hormone.

show abstract

“Natural” progesterone: information on fetal effects

Abstract: Progesterone is a potent, multi-faceted endocrine agent with an expanding therapeutic profile and a minimal scientific database for evaluating safe use during pregnancy.

Cited by 15 publications

References 142 publications

Use of progesterone supplement therapy for prevention of preterm birth: review of literatures

Use of progesterone supplement therapy for prevention of preterm birth: review of literatures

Progesterone Treatment Shows Benefit in a Pediatric Model of Moderate to Severe Bilateral Brain Injury

Folate Deficiency Could Restrain Decidual Angiogenesis in Pregnant Mice

Contact Info

Product

Resources

About