Natural Products Synthesis: A Personal Retrospective and Outlook

Carreira, Erick M.

doi:10.1002/ijch.201700127

Cited by 4 publications

(3 citation statements)

References 78 publications

(74 reference statements)

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“…Over almost two centuries, starting with Friedrich Wöhler, , researchers have developed synthetic methods to prepare various natural products and derivatives thereof as well as completely new molecules . Consequently, organic synthesis has become a highly powerful art providing versatile protocols to prepare molecules of and for our life. − Thus organic synthesis provides access to chemical compounds that cover our daily needs with respect to virtually every aspect of modern life, including clothing, hygiene, nutrition, transport, housing, and health.…”

Section: Need For a Broad Toolbox Of (Chiral) Catalysts For Organic S...mentioning

confidence: 99%

Power of Biocatalysis for Organic Synthesis

2021

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Biocatalysis, using defined enzymes for organic transformations, has become a common tool in organic synthesis, which is also frequently applied in industry. The generally high activity and outstanding stereo-, regio-, and chemoselectivity observed in many biotransformations are the result of a precise control of the reaction in the active site of the biocatalyst. This control is achieved by exact positioning of the reagents relative to each other in a fine-tuned 3D environment, by specific activating interactions between reagents and the protein, and by subtle movements of the catalyst. Enzyme engineering enables one to adapt the catalyst to the desired reaction and process. A well-filled biocatalytic toolbox is ready to be used for various reactions. Providing nonnatural reagents and conditions and evolving biocatalysts enables one to play with the myriad of options for creating novel transformations and thereby opening new, short pathways to desired target molecules. Combining several biocatalysts in one pot to perform several reactions concurrently increases the efficiency of biocatalysis even further.

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Section: Need For a Broad Toolbox Of (Chiral) Catalysts For Organic S...mentioning

confidence: 99%

Power of Biocatalysis for Organic Synthesis

2021

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“…In contrast, the more challenging the target molecules were, the more effort was put into the development of new methods, technologies and theoretical concepts to make their preparation possible. 7,8 This has made total synthesis an ideal proving ground for the utility of new synthetic developments. Furthermore, the ab initio synthesis serves to verify or correct a proposed structure and the structures of numerous compounds had to be revised when total synthesis proved the originally proposed structure to be incorrect, oen in terms of relative or absolute stereochemistry.…”

Section: Total Synthesisa Driving Force For New Developmentsmentioning

confidence: 99%

“…131 Its rst synthesis in 2011 by van Heerden et al used a Suzuki-Miyaura reaction, followed by an oxidative cyclohydrogenation and a nal 6p-electrocyclization (Scheme 8). 132 Boronic acid 21 was prepared from resorcinol (8), which can be isolated from various plant species. [133][134][135] The hydroxy groups were protected and the arene regioselectively iodinated at C-5 to select the site of borylation.…”

Section: Wood/ligninmentioning

confidence: 99%

Making natural products from renewable feedstocks: back to the roots?

2020

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Fragment-based drug design of nature-inspired compounds

Najjar

Olğaç

Ntie‐Kang

et al. 2019

Physical Sciences Reviews

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Abstract Natural product (NP)-derived drugs can be extracts, biological macromolecules, or purified small molecule substances. Small molecule drugs can be originally purified from NPs, can represent semisynthetic molecules, natural fragments containing small molecules, or are fully synthetic molecules that mimic natural compounds. New semisynthetic NP-like drugs are entering the pharmaceutical market almost every year and reveal growing interests in the application of fragment-based approaches for NPs. Thus, several NP databases were constructed to be implemented in the fragment-based drug design (FBDD) workflows. FBDD has been established previously as an approach for hit identification and lead generation. Several biophysical and computational methods are used for fragment screening to identify potential hits. Once the fragments within the binding pocket of the protein are identified, they can be grown, linked, or merged to design more active compounds. This work discusses applications of NPs and NP scaffolds to FBDD. Moreover, it briefly reviews NP databases containing fragments and reports on case studies where the approach has been successfully applied for the design of antimalarial and anticancer drug candidates.

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Natural Products Synthesis: A Personal Retrospective and Outlook

Cited by 4 publications

References 78 publications

Power of Biocatalysis for Organic Synthesis

Power of Biocatalysis for Organic Synthesis

Making natural products from renewable feedstocks: back to the roots?

Fragment-based drug design of nature-inspired compounds

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