Natural products: potential drugs for the treatment of renal fibrosis

Abstract

With the increasing prevalence and mortality, chronic kidney disease (CKD) has become a world public health problem. As the primary pathological manifestation in CKD, renal fibrosis is often used as a critical target for the treatment of CKD and inhibits the progression of CKD to end-stage renal disease (ESRD). As a potential drug, natural products have been confirmed to have the potential as a routine or supplementary therapy for chronic kidney disease, which may target renal fibrosis and act through various pharmacological activities such as anti-inflammatory and anti-oxidation of natural products. This article briefly introduces the pathological mechanism of renal fibrosis and systematically summarizes the latest research on the treatment of renal fibrosis with natural products of Chinese herbal medicines.

Self‐Assembled nanoparticles of natural bioactive molecules enhance the delivery and efficacy of paclitaxel in glioblastoma

“…The release experiment was conducted in parallel using three separate parts, each shaken at 37°C and 200 rpm. At specific time points (3,6,12,24,48,72, and 168 h), 0.2 mL of the release medium was sampled from each part. Subsequently, an equal volume of blank release medium preheated to 37°C was added to the respective parts.…”

“…10 Numerous therapeutic effects in various diseases have been attributed to bioactive molecules derived from natural sources. [11][12][13][14] Continual reports have identified a significant number of natural bioactive molecules that exhibit inhibitory properties against P-gp. [15][16][17] These bioactive molecules are widely distributed in nature, offering a vast pool of resources for the efficient and non-toxic screening and exploration of P-gp inhibitors.…”

“…Numerous therapeutic effects in various diseases have been attributed to bioactive molecules derived from natural sources 11–14 . Continual reports have identified a significant number of natural bioactive molecules that exhibit inhibitory properties against P‐gp 15–17 .…”

Correction: Natural products: potential drugs for the treatment of renal fibrosis

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Therapeutic Potential and Mechanisms of Rosmarinic Acid and the Extracts of Lamiaceae Plants for the Treatment of Fibrosis of Various Organs

“…In traditional medicine in the East and West, herbal prescriptions that are composed of several medicinal plants have been used to alleviate fibrotic diseases of the major organs, including the liver, kidneys, and lungs [11][12][13]. Interestingly, plant extracts with these effects contain several polyphenolic compounds in common, and studies on the pharmacological effects of these compounds are attracting attention [14][15][16]. A literature search by Alberti showed that plant extracts that contain hydroxycinnamic acids inhibited experimentally induced liver fibrosis [17].…”